Manteia - Molecule gene

ENSMUSG00000026836

Mus musculus

Features

Gene ID:	ENSMUSG00000026836

Biological name :	Acvr1

Synonyms :	Acvr1 / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA. / P37172

Possible biological names infered from orthology :	activin A receptor type 1 / Q04771

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	C1.1
Gene start:	58388644
Gene end:	58567157

Corresponding Affymetrix probe sets:	10482824 (MoGene1.0st) 1416786_at (Mouse Genome 430 2.0 Array) 1416787_at (Mouse Genome 430 2.0 Array) 1448460_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000088453 Ensembl peptide - ENSMUSP00000108220 Ensembl peptide - ENSMUSP00000120755 Ensembl peptide - ENSMUSP00000056784 Ensembl peptide - ENSMUSP00000108218 NCBI entrez gene - 11477 See in Manteia. MGI - MGI:87911 RefSeq - XM_017315006 RefSeq - NM_001110204 RefSeq - NM_001110205 RefSeq - NM_001355048 RefSeq - NM_001355049 RefSeq - NM_007394 RefSeq - XM_006497622 RefSeq - XM_017315005 RefSeq Peptide - NP_001103674 RefSeq Peptide - NP_001103675 RefSeq Peptide - NP_031420 RefSeq Peptide - NP_001341977 RefSeq Peptide - NP_001341978 swissprot - P37172 swissprot - B1AW87 Ensembl - ENSMUSG00000026836

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
acvr1l	ENSDARG00000014986	Danio rerio
ACVR1	ENSGALG00000037301	Gallus gallus
ACVR1	ENSG00000115170	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Acvrl1 / Q61288 / Serine/threonine-protein kinase receptor R3 / P37023* / activin A receptor like type 1*	ENSMUSG00000000530	58
Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*	ENSMUSG00000007613	48
Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*	ENSMUSG00000000532	47
Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*	ENSMUSG00000021796	46
Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*	ENSMUSG00000052430	46
Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*	ENSMUSG00000026834	46
Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*	ENSMUSG00000052155	28
Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*	ENSMUSG00000061393	28
Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*	ENSMUSG00000067336	28
Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*	ENSMUSG00000032440	28
Amhr2 / Q8K592 / Mus musculus anti-Mullerian hormone type 2 receptor (Amhr2), transcript variant 2, mRNA. / Q16671* / anti-Mullerian hormone receptor type 2*	ENSMUSG00000023047	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR000333	Ser/Thr protein kinase, TGFB receptor
IPR000472	Activin types I and II receptor domain
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR003605	GS domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000082	G1/S transition of mitotic cell cycle	ISO
biological_process	GO:0001569	branching involved in blood vessel morphogenesis	IMP
biological_process	GO:0001655	urogenital system development	ISO
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0001702	gastrulation with mouth forming second	IMP
biological_process	GO:0001707	mesoderm formation	IMP
biological_process	GO:0001755	neural crest cell migration	IMP
biological_process	GO:0002526	acute inflammatory response	IEP
biological_process	GO:0003143	embryonic heart tube morphogenesis	ISO
biological_process	GO:0003181	atrioventricular valve morphogenesis	IMP
biological_process	GO:0003183	mitral valve morphogenesis	ISO
biological_process	GO:0003203	endocardial cushion morphogenesis	IMP
biological_process	GO:0003274	endocardial cushion fusion	IMP
biological_process	GO:0003289	atrial septum primum morphogenesis	ISO
biological_process	GO:0006468	protein phosphorylation	ISO
biological_process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA
biological_process	GO:0007179	transforming growth factor beta receptor signaling pathway	TAS
biological_process	GO:0007281	germ cell development	IMP
biological_process	GO:0007368	determination of left/right symmetry	IMP
biological_process	GO:0007369	gastrulation	IMP
biological_process	GO:0007498	mesoderm development	IMP
biological_process	GO:0007507	heart development	IMP
biological_process	GO:0009968	negative regulation of signal transduction	ISO
biological_process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IMP
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018107	peptidyl-threonine phosphorylation	ISO
biological_process	GO:0023014	signal transduction by protein phosphorylation	IEA
biological_process	GO:0030278	regulation of ossification	ISO
biological_process	GO:0030335	positive regulation of cell migration	ISO
biological_process	GO:0030501	positive regulation of bone mineralization	ISO
biological_process	GO:0030509	BMP signaling pathway	ISO
biological_process	GO:0032924	activin receptor signaling pathway	ISO
biological_process	GO:0032926	negative regulation of activin receptor signaling pathway	ISO
biological_process	GO:0045669	positive regulation of osteoblast differentiation	ISO
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	ISO
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0051145	smooth muscle cell differentiation	IMP
biological_process	GO:0060037	pharyngeal system development	IMP
biological_process	GO:0060389	pathway-restricted SMAD protein phosphorylation	ISO
biological_process	GO:0060412	ventricular septum morphogenesis	IMP
biological_process	GO:0060923	cardiac muscle cell fate commitment	ISO
biological_process	GO:0061312	BMP signaling pathway involved in heart development	IMP
biological_process	GO:0061445	endocardial cushion cell fate commitment	ISO
biological_process	GO:0071773	cellular response to BMP stimulus	ISO
biological_process	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP
biological_process	GO:2000017	positive regulation of determination of dorsal identity	ISO
biological_process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO
cellular_component	GO:0005887	integral component of plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0045177	apical part of cell	IDA
cellular_component	GO:0048179	activin receptor complex	ISO
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	ISO
molecular_function	GO:0004674	protein serine/threonine kinase activity	ISO
molecular_function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA
molecular_function	GO:0004702	obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity	IEA
molecular_function	GO:0005025	transforming growth factor beta receptor activity, type I	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	ISO
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016361	activin receptor activity, type I	ISO
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019838	growth factor binding	IDA
molecular_function	GO:0042803	protein homodimerization activity	ISO
molecular_function	GO:0046332	SMAD binding	ISO
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0048185	activin binding	ISO
molecular_function	GO:0050431	transforming growth factor beta binding	ISO

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000029	abnormal malleus morphology	"structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000085	large anterior fontanelle	"enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000088	short mandible	"reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000163	abnormal cartilage morphology	"anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Acvr2a^tm1Hsch/Acvr2a^tm1Hsch,Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo Genetic Background: involves: 129S1/Sv * 129S4/SvJae * FVB/N
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000297	abnormal endocardial cushion morphology	"malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000301	reduced size of endocardial cushions	"smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000435	shortened head	"reduced anterior-posterior length of the head" [J:42035]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000458	abnormal mandible morphology	"malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000460	mandible hypoplasia	"arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0000559	abnormal femur morphology	"structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0001436	abnormal suckling behavior	"reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Egr2^tm1Pch/Egr2^tm3Pch Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0001675	abnormal ectoderm development	"failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0001680	abnormal mesoderm development	"failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr2^tm1Pch/Egr2^tm3Pch Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Acvr1^tm1Bhr/Acvr1^tm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Acvr1^tm1.1Vk/Acvr1^tm1.1Vk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001683	absent mesoderm	"missing or failure to differentiate the middle primary germ layer " [J:40594]	Show Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0001695	abnormal gastrulation	"anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Egr2^tm1Pch/Egr2^tm3Pch Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Acvr1^tm1Bhr/Acvr1^tm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Acvr1^tm1.1Vk/Acvr1^tm1.1Vk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Egr2^tm1Pch/Egr2^tm3Pch Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Acvr1^tm1Bhr/Acvr1^tm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Acvr1^tm1.1Vk/Acvr1^tm1.1Vk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001710	absent amniotic folds	"failure of amnion to form involutions" [J:40594]	Show Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Egr2^tm1Pch/Egr2^tm3Pch Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Acvr1^tm1Bhr/Acvr1^tm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Acvr1^tm1.1Vk/Acvr1^tm1.1Vk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0001846	increased inflammatory response	"greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor⁺,Tg(tetO-cre)1Jaw/0 Genetic Background:* involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6NTac
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0002230	abnormal primitive streak formation	"anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr2^tm1Pch/Egr2^tm3Pch Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002231	abnormal primitive streak morphology	"anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm1Bhr/Acvr1^tm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Acvr1^tm1.1Vk/Acvr1^tm1.1Vk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0002672	abnormal branchial arch artery morphology	"malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0002745	abnormal atrioventricular valve morphology	"malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0002932	abnormal joint	"defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0003048	abnormal cervical vertebrae morphology	"malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0003087	absent allantois	"missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Egr2^tm1Pch/Egr2^tm3Pch Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0003409	decreased width of hypertrophic chondrocyte zone	"decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0003543	abnormal vascular endothelial cell differentiation	"anomaly in the process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0003886	abnormal embryonic epiblast morphology	"anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Egr2^tm1Pch/Egr2^tm3Pch Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Acvr1^tm1Bhr/Acvr1^tm1Bhr Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Acvr1^tm1.1Vk/Acvr1^tm1.1Vk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0003988	disorganized embryonic tissue	"a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]	Show Allelic Composition: Egr2^tm1Pch/Egr2^tm3Pch Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0004113	abnormal aortic arch morphology	"structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0004160	retroesophageal right subclavian artery	"the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0004351	short humerus	"reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0004355	short radius	"reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0004467	absent zygomatic bone	"absence of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0004469	abnormal zygomatic arch morphology	"any structural anomaly of the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0004609	vertebral fusion	"the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0004635	short metatarsal bones	"reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0005030	absent amnion	"missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]	Show Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0005306	abnormal phalanx morphology	"aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0005566	decreased blood urea nitrogen level	"low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{em1(CAG-cas9,-EGFP)Rsky}/Gt(ROSA)26Sor⁺ Genetic Background:* C57BL/6N-Gt(ROSA)26Sor^{em1(CAG-cas9*,-EGFP)Rsky}
MP:0005587	abnormal Meckel s cartilage morphology	"structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0006355	abnormal sixth branchial arch artery morphology	"any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0006356	abnormal third branchial arch artery morphology	"any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0008069	abnormal joint mobility	"anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0008375	short manubrium	"reduced length of the handle of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0008825	abnormal cardiac epithelial to mesenchymal transition	"anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0009415	skeletal muscle degeneration	"pathological deterioration of skeletal muscle tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0009593	absent chorion	"absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0009885	abnormal palatal shelf elevation	"any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0010079	osteochondroma	"a benign cartilagenous neoplasm that consists of a pedicle of normal bone capped by a region of proliferating cartilage cells; most often associated with one or more of the long bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
MP:0010464	abnormal aortic arch and aortic arch branch attachment	"any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0010563	increased heart right ventricle size	"greater than average size of the right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0010587	conotruncal ridge hypoplasia	"underdevelopment or reduced size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0010592	abnormal atrioventricular septum morphology	"any structural anomaly of the wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
MP:0010663	abnormal brachiocephalic trunk morphology	"any structural anomaly of the short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Egr2^tm1Pch/Egr2^tm3Pch Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Mbp^shi-mld/Mbp^shi-mld Genetic Background: MDB/Dt
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
MP:0011186	abnormal visceral endoderm morphology	"any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]	Show Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0011190	thick embryonic epiblast	"increased thickness of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]	Show Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0012749	decreased cardiac neural crest cell number	"reduction in the number of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT), and contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [MGI:anna]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0012750	absent cardiac neural crest cells	"absence or loss of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia; ablation of cardiac NCCs results in cardiac outflow defects" [MGI:anna]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0012751	impaired cardiac neural crest cell differentiation	"abnormal or arrest of differentiation or patterning of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs have the potential to differentiate into smooth muscle cells of the cardiac outflow tract and its septum, walls of aortic and arch-derived arteries, all of the parasympathetic innervation of the heart, and the connective tissue of the glands in the head and neck region, including the thymus, thyroid and parathyroid glands" [MGI:anna]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0012752	abnormal cardiac neural crest cell migration	"any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0014100	increased chondrocyte proliferation	"increased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J
MP:0014167	ectopic bone	"the appearance of an extra bone structure at an atypical location" [MGI:csmith]	Show Allelic Composition: Acvr1^tm1Emsh/Acvr1⁺ Genetic Background: C57BL/6-Acvr1^tm1Emsh
MP:0020039	increased bone ossification	"increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * C57BL/6NTac * SJL/J Allelic Composition: Acvr1^tm2.1Vlcg/Acvr1⁺,Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor⁺,Tg(tetO-cre)1Jaw/0 Genetic Background:* involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6NTac
MP:0030111	absent temporomandibular joint	"absence of the synovial articulation between the head of the mandibular condoyloid process and the mandibular fossa and articular tubercle of the temporal bones" [MGI:anna]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0030120	absent retrotympanic process	"absence of the posterior extension of the squamosal bone that normally lies just above the incus" [MGI:anna, PMID:28566723]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0030121	small temporal bone squamous part	"reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0030170	absent mandibular symphysis	"absence of the fibrocartilagenous union of the two halves of the mandible (embryonic stages)" [MGI:anna]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0030283	small mandibular coronoid process	"reduced size of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:anna]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0030311	abnormal mandibular fossa morphology	"any structural anomaly of the depression in the temporal bone that articulates with the mandible; it is a part of the temporomandibular joint and lodges the condyle of the mandible; in the temporal bone, the mandibular fossa is bounded anteriorly by the articular tubercle and posteriorly by the tympanic portion of the temporal bone, which separates it from the external acoustic meatus; the fossa is divided into two parts by a narrow slit, the petrotympanic fissure" [https://en.wikipedia.org/wiki/Mandibular_fossa, https://radiopaedia.org/articles/mandibular-fossa]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0030379	abnormal frontal bone squamous part morphology	"any structural anomaly of the vertical and largest, flat part of the frontal bone which forms the forehead and comprises the frontal sinuses; this part contains the supraorbital notch, the superciliary arches, the glabella, and the zygomatic processes which arise caudolaterally from the squamous part and articulate with the zygomatic bone" [https://www.getbodysmart.com/ap/skeletalsystem/skeleton/axial/skull/cranialbones/frontal/tutorial.html, https://www.kenhub.com/en/library/anatomy/the-frontal-bone]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0030416	absent temporal bone zygomatic process	"missing the long, arched process that projects from the lower region of the squamous part of the temporal bone and articulates with the zygomatic bone" [MGI:anna]	Show Allelic Composition: Acvr1^tm1Vk/Acvr1^tm1.1Vk,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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