ENSMUSG00000026834


Mus musculus

Features
Gene ID: ENSMUSG00000026834
  
Biological name :Acvr1c
  
Synonyms : Activin receptor type-1C / Acvr1c / Q8K348
  
Possible biological names infered from orthology : activin A receptor type 1C / Q8NER5
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.1
Gene start: 58267453
Gene end: 58357895
  
Corresponding Affymetrix probe sets: 10482814 (MoGene1.0st)   1428032_at (Mouse Genome 430 2.0 Array)   1438309_at (Mouse Genome 430 2.0 Array)   1443225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108226
Ensembl peptide - ENSMUSP00000119776
Ensembl peptide - ENSMUSP00000108227
Ensembl peptide - ENSMUSP00000028178
Ensembl peptide - ENSMUSP00000097663
NCBI entrez gene - 269275     See in Manteia.
MGI - MGI:2661081
RefSeq - XM_011239108
RefSeq - XM_006498085
RefSeq - XM_006498086
RefSeq - NM_001033369
RefSeq - NM_001111030
RefSeq Peptide - NP_001104500
RefSeq Peptide - NP_001028541
swissprot - Q3V348
swissprot - Q8K348
swissprot - D3Z1K2
swissprot - A2AJR5
swissprot - A2AJR6
Ensembl - ENSMUSG00000026834
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACVR1CENSDARG00000086172Danio rerio
 ACVR1CENSGALG00000041257Gallus gallus
 ACVR1CENSG00000123612Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*ENSMUSG0000000761366
Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*ENSMUSG0000000053264
Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*ENSMUSG0000002179649
Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*ENSMUSG0000005243049
Acvr1 / P37172 / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA. / Q04771* / activin A receptor type 1*ENSMUSG0000002683648
Acvrl1 / Q61288 / Serine/threonine-protein kinase receptor R3 / P37023* / activin A receptor like type 1*ENSMUSG0000000053046
Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*ENSMUSG0000006139331
Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*ENSMUSG0000003244031
Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*ENSMUSG0000005215530
Amhr2 / Q8K592 / Mus musculus anti-Mullerian hormone type 2 receptor (Amhr2), transcript variant 2, mRNA. / Q16671* / anti-Mullerian hormone receptor type 2*ENSMUSG0000002304727
Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*ENSMUSG0000006733627


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001834 trophectodermal cell proliferation ISO
 biological_processGO:0002021 response to dietary excess IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019915 lipid storage IMP
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030262 apoptotic nuclear changes IEA
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0038092 nodal signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process ISS
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0046676 negative regulation of insulin secretion IMP
 biological_processGO:1901164 negative regulation of trophoblast cell migration IEA
 biological_processGO:1901383 negative regulation of chorionic trophoblast cell proliferation IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048179 activin receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016361 activin receptor activity, type I IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0038100 nodal binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048185 activin binding ISO


Pathways (from Reactome)
Pathway description
Signaling by Activin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Acvr1ctm1Cfi/Acvr1ctm1Cfi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026124 Cfc1 / P97766 / Cryptic protein / CFC1B* / P0CG36* / P0CG37* / cripto, FRL-1, cryptic family 1* / cripto, FRL-1, cryptic family 1B*  / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction
 ENSMUSG00000109523 Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*  / complex / reaction
 ENSMUSG00000037171 Nodal / P43021 / Q96S42* / nodal growth differentiation factor*  / reaction / complex
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / complex
 ENSMUSG00000037035 Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*  / complex / reaction
 ENSMUSG00000041324 Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*  / complex / reaction
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / complex / reaction
 ENSMUSG00000026834 Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*  / reaction / complex
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction






 

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