ENSMUSG00000061393


Mus musculus

Features
Gene ID: ENSMUSG00000061393
  
Biological name :Acvr2b
  
Synonyms : Activin receptor type-2B / Acvr2b / P27040
  
Possible biological names infered from orthology : activin A receptor type 2B / Q13705
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F3
Gene start: 119402118
Gene end: 119434995
  
Corresponding Affymetrix probe sets: 10590169 (MoGene1.0st)   1419140_at (Mouse Genome 430 2.0 Array)   1439856_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035093
Ensembl peptide - ENSMUSP00000126108
Ensembl peptide - ENSMUSP00000150566
NCBI entrez gene - 11481     See in Manteia.
MGI - MGI:87912
RefSeq - XM_006511926
RefSeq - NM_001313757
RefSeq - NM_007397
RefSeq Peptide - NP_031423
RefSeq Peptide - NP_001300686
swissprot - P27040
Ensembl - ENSMUSG00000061393
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acvr2baENSDARG00000044422Danio rerio
 acvr2bbENSDARG00000103108Danio rerio
 ACVR2BENSGALG00000006158Gallus gallus
 ACVR2BENSG00000114739Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*ENSMUSG0000005215564
Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*ENSMUSG0000003244034
Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*ENSMUSG0000006733633
Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*ENSMUSG0000002683428
Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*ENSMUSG0000000053227
Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*ENSMUSG0000000761326
Acvr1 / P37172 / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA. / Q04771* / activin A receptor type 1*ENSMUSG0000002683626
Acvrl1 / Q61288 / Serine/threonine-protein kinase receptor R3 / P37023* / activin A receptor like type 1*ENSMUSG0000000053026
Amhr2 / Q8K592 / Mus musculus anti-Mullerian hormone type 2 receptor (Amhr2), transcript variant 2, mRNA. / Q16671* / anti-Mullerian hormone receptor type 2*ENSMUSG0000002304726
Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*ENSMUSG0000005243026
Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*ENSMUSG0000002179625


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001702 gastrulation with mouth forming second IGI
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007389 pattern specification process IGI
 biological_processGO:0007498 mesoderm development IGI
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009749 response to glucose IGI
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0009952 anterior/posterior pattern specification ISO
 biological_processGO:0009966 regulation of signal transduction IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030073 insulin secretion IGI
 biological_processGO:0030324 lung development IGI
 biological_processGO:0030501 positive regulation of bone mineralization ISO
 biological_processGO:0030509 BMP signaling pathway ISO
 biological_processGO:0031016 pancreas development IGI
 biological_processGO:0032147 activation of protein kinase activity IDA
 biological_processGO:0032924 activin receptor signaling pathway ISO
 biological_processGO:0032927 positive regulation of activin receptor signaling pathway ISO
 biological_processGO:0035265 organ growth IGI
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation ISO
 biological_processGO:0048617 embryonic foregut morphogenesis IMP
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060836 lymphatic endothelial cell differentiation IMP
 biological_processGO:0060840 artery development IMP
 biological_processGO:0060841 venous blood vessel development IMP
 biological_processGO:0061298 retina vasculature development in camera-type eye IMP
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048185 activin binding IPI


Pathways (from Reactome)
Pathway description
Signaling by Activin
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

Allelic Composition: Acvr2btm1Enl/Acvr2btm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Acvr2atm1Hsch/Acvr2a+,Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Acvr2atm1Hsch/Acvr2a+,Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * FVB/N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0000650 mesocardia "cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btg2tm1Spo/Btg2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Acvr2atm1Hsch/Acvr2a+,Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Acvr2atm1Hsch/Acvr2a+,Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * FVB/N

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * FVB/N

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acvr2atm1Hsch/Acvr2a+,Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * FVB/N

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Btg2tm1Spo/Btg2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0003604 single kidney 
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

Allelic Composition: Acvr2btm1Enl/Acvr2btm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Acvr2atm1Hsch/Acvr2a+,Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Acvr2atm1Hsch/Acvr2a+,Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * FVB/N

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acvr2btm1Enl/Acvr2btm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Acvr2atm1Hsch/Acvr2a+,Acvr2btm1Spo/Acvr2btm1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Acvr2atm1Hsch/Acvr2a+,Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * FVB/N

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acvr2btm1Enl/Acvr2btm1Enl
Genetic Background: involves: 129S4/SvJae

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0006061 right atrial isomerism "altered asymmetric patterning of the atria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0006206 embryonic lethality before turning of embryo "death anytime after somite formation but before embryo turning (E8 to less than E9)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * FVB/N

 MP:0010238 increased skeletal muscle weight "greater than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0011191 increased embryonic epiblast cell apoptosis "increase in the number of embryonic epiblast cells undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0012081 absent heart tube "absence of the primitive epithelial cardiac tube before the division into the chambers of the mature heart" [MGI:anna]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1.1Spo/Acvr2btm1.1Spo
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * FVB/N

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0012724 failure of head fold formation "inability to form the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; the head fold constitutes the first body fold, and initiates brain, foregut and heart development" [MGI:anna]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000532 Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*  / complex / reaction
 ENSMUSG00000026124 Cfc1 / P97766 / Cryptic protein / CFC1B* / P0CG36* / P0CG37* / cripto, FRL-1, cryptic family 1* / cripto, FRL-1, cryptic family 1B*  / complex
 ENSMUSG00000021706 Q80U44 / Zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / zinc finger FYVE-type containing 16*  / complex / reaction
 ENSMUSG00000026834 Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*  / complex
 ENSMUSG00000027358 Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*  / reaction / complex
 ENSMUSG00000037035 Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*  / reaction / complex
 ENSMUSG00000041324 Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*  / reaction / complex
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / reaction / complex
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / reaction / complex
 ENSMUSG00000036867 Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*  / complex / reaction
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / reaction / complex
 ENSMUSG00000038780 Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*  / reaction / complex
 ENSMUSG00000109523 Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*  / complex / reaction
 ENSMUSG00000037171 Nodal / P43021 / Q96S42* / nodal growth differentiation factor*  / reaction / complex
 ENSMUSG00000021540 Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*  / complex / reaction
 ENSMUSG00000031681 Smad1 / P70340 / SMAD family member 1 / Q15797*  / reaction / complex
 ENSMUSG00000027796 Smad9 / Q9JIW5 / Mothers against decapentaplegic homolog 9 / O15198* / SMAD family member 9*  / reaction / complex
 ENSMUSG00000052430 Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*  / reaction / complex
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / complex / reaction
 ENSMUSG00000021796 Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSMUSG00000067336 Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*  / complex






 

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