ENSMUSG00000027358


Mus musculus

Features
Gene ID: ENSMUSG00000027358
  
Biological name :Bmp2
  
Synonyms : Bmp2 / Bone morphotic protein 2 / P21274
  
Possible biological names infered from orthology : bone morphogenetic protein 2 / P12643
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F2
Gene start: 133552159
Gene end: 133562885
  
Corresponding Affymetrix probe sets: 10476395 (MoGene1.0st)   1423635_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028836
NCBI entrez gene - 12156     See in Manteia.
MGI - MGI:88177
RefSeq - NM_007553
RefSeq - XM_006498619
RefSeq Peptide - NP_031579
swissprot - P21274
Ensembl - ENSMUSG00000027358
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp2aENSDARG00000013409Danio rerio
 bmp2bENSDARG00000041430Danio rerio
 BMP2ENSGALG00000029301Gallus gallus
 BMP2ENSG00000125845Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp4 / P21275 / Bone morphotic protein 4 / P12644* / bone morphogenetic protein 4*ENSMUSG0000002183562
Bmp5 / P49003 / Bone morphotic protein 5 / P22003* / bone morphogenetic protein 5*ENSMUSG0000003217933
Bmp6 / P20722 / Bone morphotic protein 6 / P22004* / bone morphogenetic protein 6*ENSMUSG0000003900433
Bmp7 / P23359 / Bone morphotic protein 7 / P18075* / bone morphogenetic protein 7*ENSMUSG0000000899932
Bmp8a / P34821 / Bone morphotic protein 8A / BMP8B* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000003272630
Bmp10 / Q9R229 / Bone morphotic protein 10 / O95393* / bone morphogenetic protein 10*ENSMUSG0000003004630
Gdf5 / P43027 / Growth/differentiation factor 5 / P43026*ENSMUSG0000003825929
Bmp8b / P55105 / Bone morphotic protein 8B / BMP8A* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000000238429
Gdf2 / Q9WV56 / Growth/differentiation factor 2 / Q9UK05*ENSMUSG0000007262528
Gdf6 / P43028 / Growth/differentiation factor 6 / Q6KF10*ENSMUSG0000005127928
Gdf7 / P43029 / Growth/differentiation factor 7 / Q7Z4P5*ENSMUSG0000003766025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IGI
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0003130 BMP signaling pathway involved in heart induction IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 biological_processGO:0003203 endocardial cushion morphogenesis IMP
 biological_processGO:0003308 negative regulation of Wnt signaling pathway involved in heart development IEA
 biological_processGO:0006029 proteoglycan metabolic process IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007219 Notch signaling pathway IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0010894 negative regulation of steroid biosynthetic process IEA
 biological_processGO:0010922 positive regulation of phosphatase activity ISO
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021978 telencephalon regionalization IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IDA
 biological_processGO:0030282 bone mineralization IGI
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0031648 protein destabilization IGI
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032348 negative regulation of aldosterone biosynthetic process IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IMP
 biological_processGO:0035051 cardiocyte differentiation IEA
 biological_processGO:0035054 embryonic heart tube anterior/posterior pattern specification IMP
 biological_processGO:0035630 bone mineralization involved in bone maturation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IDA
 biological_processGO:0042482 positive regulation of odontogenesis IDA
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IGI
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045597 positive regulation of cell differentiation IDA
 biological_processGO:0045600 positive regulation of fat cell differentiation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045778 positive regulation of ossification ISO
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IGI
 biological_processGO:0048762 mesenchymal cell differentiation IEA
 biological_processGO:0048839 inner ear development IDA
 biological_processGO:0050769 positive regulation of neurogenesis ISO
 biological_processGO:0051042 negative regulation of calcium-independent cell-cell adhesion IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060039 pericardium development IMP
 biological_processGO:0060128 corticotropin hormone secreting cell differentiation IDA
 biological_processGO:0060129 thyroid-stimulating hormone-secreting cell differentiation IDA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IEA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0060485 mesenchyme development IEA
 biological_processGO:0060804 positive regulation of Wnt signaling pathway by BMP signaling pathway IDA
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:0072138 mesenchymal cell proliferation involved in ureteric bud development IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IGI
 biological_processGO:2000065 negative regulation of cortisol biosynthetic process IEA
 biological_processGO:2000726 negative regulation of cardiac muscle cell differentiation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070724 BMP receptor complex IEA
 molecular_functionGO:0004745 retinol dehydrogenase activity IDA
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0019211 phosphatase activator activity ISO
 molecular_functionGO:0039706 co-receptor binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070700 BMP receptor binding IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000077 abnormal interparietal bone morphology "malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000085 large anterior fontanelle "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp7tm1Rob/Bmp7tm1Rob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000168 abnormal bone marrow development "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

Allelic Composition: Bmp2tm1.1Jfm/Bmp2tm1.1Jfm
Genetic Background: Not Specified

Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
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Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ush1ctm1Bkts/Ush1ctm1Bkts
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Adartm1Olds/Adartm1Olds
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: 129S2/SvPas-Stat6tm1Gru

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: 129S2/SvPas-Stat6tm1Gru

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1.1Jfm
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp7tm1Rob/Bmp7tm1Rob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp7tm1Rob/Bmp7+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp4tm1Jfm/Bmp4+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp7tm1Rob/Bmp7tm1Rob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002293 long gestation period "increase in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0003189 fused joints 
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003795 abnormal bone structure 
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0003854 abnormal forelimb stylopod morphology 
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003855 abnormal forelimb zeugopod morphology 
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003856 abnormal hindlimb stylopod morphology 
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003857 abnormal hindlimb zeugopod morphology 
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0004384 small interparietal bone "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004423 abnormal squamosal bone morphology "any structural anomaly of the thin, platelike part of the temporal bone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004458 absent alisphenoid bone "absence of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004459 small alisphenoid bone "reduced size of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004467 absent zygomatic bone "absence of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004468 small zygomatic bone "reduced size of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004470 small nasal bone "reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004539 absent maxilla "missing the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004558 delayed allantois development "late onset of development of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0004574 broad limb buds "increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004595 abnormal mandibular condyloid process morphology "any structural anomaly of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004596 abnormal mandibular angle morphology "any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0004610 small vertebrae "reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0004899 absent squamosal bone "absence of the thin, plate-like part of the temporal bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004911 absent mandibular condyloid process "absence of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004912 absent mandibular coronoid process "absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004913 absent mandibular angle "absence of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp7tm1Rob/Bmp7tm1Rob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1.1Jfm
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0006107 abnormal atrioventricular canal morphology "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009250 abnormal appendicular skeleton morphology "any structural anomaly of the bones of the limbs, shoulder and pelvic girdles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp7tm1Rob/Bmp7tm1Rob,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0009382 abnormal cardiac jelly morphology "any structural anomaly of the gelatinous noncellular material between the endothelial lining and the myocardial layer of the developing heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009874 abnormal interdigital cell death "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010224 abnormal heart ventricle outflow tract morphology "any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Adartm1Olds/Adartm1Olds
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bmp2tm1.1Jfm/Bmp2tm1.1Jfm
Genetic Background: Not Specified

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011197 abnormal proamniotic cavity morphology "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0011711 decreased osteoblast differentiation 
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0012270 cardiac edema "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna]
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Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
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Allelic Composition: Bmp2tm1.2Mis/Bmp2tm1.2Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0030121 small temporal bone squamous part "reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna]
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Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / reaction / complex
 ENSMUSG00000052430 Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*  / reaction / complex
 ENSMUSG00000067336 Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSMUSG00000021796 Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSMUSG00000027358 Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*  / complex
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / reaction / complex
 ENSMUSG00000038780 Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*  / complex / reaction
 ENSMUSG00000021540 Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*  / complex / reaction
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / reaction / complex
 ENSMUSG00000036867 Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*  / reaction / complex
 ENSMUSG00000027796 Smad9 / Q9JIW5 / Mothers against decapentaplegic homolog 9 / O15198* / SMAD family member 9*  / reaction / complex
 ENSMUSG00000021706 Q80U44 / Zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / zinc finger FYVE-type containing 16*  / reaction / complex
 ENSMUSG00000031681 Smad1 / P70340 / SMAD family member 1 / Q15797*  / reaction / complex






 

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