ENSDARG00000041430


Danio rerio

Features
Gene ID: ENSDARG00000041430
  
Biological name :bmp2b
  
Synonyms : bmp2b / bone morphogenetic protein 2b
  
Possible biological names infered from orthology : BMP2 / bone morphogenetic protein 2 / Bone morphotic protein 2 / P12643 / P21274
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 45893173
Gene end: 45899149
  
Corresponding Affymetrix probe sets: Dr.568.1.S1_at (Zebrafish Array)   NM_131360_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000107417
NCBI entrez gene - 30632     See in Manteia.
RefSeq - NM_131360
RefSeq Peptide - NP_571435
swissprot - O93369
ZFIN ID - ZDB-GENE-980526-474
Ensembl - ENSDARG00000041430
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BMP2ENSGALG00000029301Gallus gallus
 BMP2ENSG00000125845Homo sapiens
 Bmp2ENSMUSG00000027358Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bmp2a / bone morphogenetic protein 2a / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*ENSDARG0000001340963
bmp4 / bone morphogenetic protein 4 / P12644* / P21275* / Bone morphotic protein 4 *ENSDARG0000001999555
bmp16 / bone morphogenetic protein 16ENSDARG0000010367938
bmp5 / bone morphogenetic protein 5 / P22003*ENSDARG0000010170130
bmp7b / bone morphogenetic protein 7bENSDARG0000006323030
bmp6 / bone morphogenetic protein 6 / P20722* / P22004* / Bone morphotic protein 6 *ENSDARG0000001568629
bmp8a / bone morphogenetic protein 8a / BMP8B* / Q7Z5Y6* / P34820* / P34821* / P55105* / Bone morphotic protein 8B * / Bone morphotic protein 8A * / bone morphogenetic protein 8b*ENSDARG0000003567728
bmp10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *ENSDARG0000006176928
admp / anti-dorsalizing morphogenic proteinENSDARG0000002537228
bmp7a / bone morphogenetic protein 7a / BMP7* / P23359* / P18075* / Bone morphotic protein 7 * / bone morphogenetic protein 7*ENSDARG0000001826028
bmp10l / bone morphogenetic protein 10, like / BMP10* / O95393* / bone morphogenetic protein 10*ENSDARG0000010923327
gdf2 / F1QWZ4 / growth differentiation factor 2 / Q9UK05* / Q9WV56*ENSDARG0000005917327
gdf6a / P85857 / growth differentiation factor 6a / GDF6* / P43028* / Q6KF10* / growth differentiation factor 6*ENSDARG0000005347927
gdf5 / growth differentiation factor 5 / P43026* / P43027*ENSDARG0000000276026
gdf7 / growth differentiation factor 7 / P43029* / Q7Z4P5*ENSDARG0000004278425
gdf6b / A8E7N9 / growth differentiation factor 6b / GDF6* / Q6KF10* / P43028* / growth differentiation factor 6*ENSDARG0000000551024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001710 mesodermal cell fate commitment IGI
 biological_processGO:0001889 liver development IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0009950 dorsal/ventral axis specification IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0021703 locus ceruleus development IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030509 BMP signaling pathway IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway IDA
 biological_processGO:0030903 notochord development IGI
 biological_processGO:0042074 cell migration involved in gastrulation IGI
 biological_processGO:0042664 negative regulation of endodermal cell fate specification IGI
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045168 cell-cell signaling involved in cell fate commitment IMP
 biological_processGO:0048264 determination of ventral identity IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0048752 semicircular canal morphogenesis IMP
 biological_processGO:0055015 ventricular cardiac muscle cell development IMP
 biological_processGO:0060030 dorsal convergence IGI
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0060876 semicircular canal formation IMP
 biological_processGO:0061131 pancreas field specification IDA
 biological_processGO:0090008 hypoblast development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0070700 BMP receptor binding IBA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle myofibril disorganized , abnormal
Show

 ZFA:0000022 floor plate floor plate increased width , abnormal
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 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
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 ZFA:0000040 median fin fold median fin fold hypoplastic , abnormal
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 ZFA:0000050 optic vesicle optic vesicle mislocalised , abnormal
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 ZFA:0000077 tail bud tail bud increased size , abnormal
tail bud mislocalised posteriorly , abnormal
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 ZFA:0000084 yolk yolk broken , abnormal
yolk protruding , abnormal
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 ZFA:0000092 axis axis decreased length , abnormal
axis mislocalised posteriorly , abnormal
axis thickness , abnormal
axis increased length , abnormal
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 ZFA:0000135 notochord notochord morphology , abnormal
notochord undulate , abnormal
notochord increased width , abnormal
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 ZFA:0000138 otic placode otic placode aplastic , abnormal
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 ZFA:0000150 pronephric duct pronephric duct aplastic , abnormal
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 ZFA:0000155 somite somite increased length , abnormal
somite malformed , abnormal
somite fused with somite , abnormal
somite increased width , abnormal
somite circular , abnormal
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 ZFA:0000255 paraxial mesoderm paraxial mesoderm morphology , abnormal
paraxial mesoderm has extra parts of type adaxial cell , abnormal
paraxial mesoderm anterior-posterior axis decreased length , abnormal
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 ZFA:0000431 semicircular canal semicircular canal malformed , abnormal
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 ZFA:0000823 rhombomere 5 rhombomere 5 left side fused with rhombomere 5 right side, abnormal
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 ZFA:0000948 rhombomere 3 rhombomere 3 left side fused with rhombomere 3 right side, abnormal
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 ZFA:0001058 caudal fin caudal fin hypoplastic , abnormal
caudal fin ventral region hypoplastic , abnormal
caudal fin shortened , abnormal
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 ZFA:0001065 lateral mesoderm lateral mesoderm mislocalised , abnormal
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 ZFA:0001069 ventral fin fold ventral fin fold hypoplastic , abnormal
ventral fin fold absent , abnormal
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 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism anterior-posterior axis decreased length , abnormal
whole organism decreased length , abnormal
whole organism ovate , abnormal
whole organism morphology , abnormal
whole organism elongated , abnormal
whole organism viability , abnormal
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 ZFA:0001115 trunk trunk curved , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
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 ZFA:0001120 neuroectoderm neuroectoderm wholly dorsalized , abnormal
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 ZFA:0001135 neural tube neural tube morphology , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
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 ZFA:0007035 spinal cord neural rod spinal cord neural rod neuron absent , abnormal
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 ZFA:0009051 interneuron interneuron increased amount , abnormal
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 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron decreased amount , abnormal
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 ZFA:0009248 neuron neuron increased amount , abnormal
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 ZFA:0009288 primordial germ cell primordial germ cell mislocalised , abnormal
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 ZFA:0009325 erythroid lineage cell erythroid lineage cell absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000016086 smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / reaction / complex
 ENSDARG00000027199 smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *  / reaction / complex
 ENSDARG00000019728 bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSDARG00000021938 alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *  / reaction / complex
 ENSDARG00000037238 smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *  / reaction / complex
 ENSDARG00000038067 A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / reaction / complex
 ENSDARG00000031763 smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *  / complex / reaction
 ENSDARG00000020057 bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSDARG00000104700 acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*  / complex / reaction
 ENSDARG00000041430 bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / complex
 ENSDARG00000105045 bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSDARG00000103108 acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*  / complex / reaction
 ENSDARG00000056057 grem2a / gremlin 2, DAN family BMP antagonist a / GREM2* / Q9H772* / O88273* / Gremlin-2 * / gremlin 2, DAN family BMP antagonist*  / reaction / complex
 ENSDARG00000075747 zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / Q80U44* / zinc finger FYVE-type containing 16*  / complex / reaction
 ENSDARG00000011188 acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*  / reaction / complex
 ENSDARG00000044422 acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*  / reaction / complex
 ENSDARG00000058819 nog1 / noggin 1 / NOG* / noggin* / P97466* / Q13253*  / reaction / complex
 ENSDARG00000011941 bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSDARG00000039576 fstl1b / follistatin-like 1b / FSTL1* / Q12841* / Q62356* / follistatin like 1* / Follistatin-related protein 1 *  / complex / reaction






 

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