ENSDARG00000019995


Danio rerio

Features
Gene ID: ENSDARG00000019995
  
Biological name :bmp4
  
Synonyms : bmp4 / bone morphogenetic protein 4
  
Possible biological names infered from orthology : Bone morphotic protein 4 / P12644 / P21275
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 50564070
Gene end: 50586135
  
Corresponding Affymetrix probe sets: Dr.567.2.S1_a_at (Zebrafish Array)   NM_131342_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000069635
NCBI entrez gene - 30612     See in Manteia.
RefSeq - NM_131342
RefSeq Peptide - NP_571417
swissprot - F1QAD6
ZFIN ID - ZDB-GENE-980528-2059
Ensembl - ENSDARG00000019995
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BMP4ENSGALG00000012429Gallus gallus
 BMP4ENSG00000125378Homo sapiens
 Bmp4ENSMUSG00000021835Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*ENSDARG0000004143057
bmp2a / bone morphogenetic protein 2a / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*ENSDARG0000001340955
bmp16 / bone morphogenetic protein 16ENSDARG0000010367940
bmp7b / bone morphogenetic protein 7bENSDARG0000006323033
bmp5 / bone morphogenetic protein 5 / P22003*ENSDARG0000010170132
bmp7a / bone morphogenetic protein 7a / BMP7* / P23359* / P18075* / Bone morphotic protein 7 * / bone morphogenetic protein 7*ENSDARG0000001826031
bmp6 / bone morphogenetic protein 6 / P20722* / P22004* / Bone morphotic protein 6 *ENSDARG0000001568631
admp / anti-dorsalizing morphogenic proteinENSDARG0000002537230
bmp8a / bone morphogenetic protein 8a / BMP8B* / Q7Z5Y6* / P34820* / P34821* / P55105* / Bone morphotic protein 8B * / Bone morphotic protein 8A * / bone morphogenetic protein 8b*ENSDARG0000003567729
bmp10l / bone morphogenetic protein 10, like / BMP10* / O95393* / bone morphogenetic protein 10*ENSDARG0000010923327
bmp10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *ENSDARG0000006176927
gdf5 / growth differentiation factor 5 / P43026* / P43027*ENSDARG0000000276027
gdf7 / growth differentiation factor 7 / P43029* / Q7Z4P5*ENSDARG0000004278427
gdf6b / A8E7N9 / growth differentiation factor 6b / GDF6* / Q6KF10* / P43028* / growth differentiation factor 6*ENSDARG0000000551027
gdf6a / P85857 / growth differentiation factor 6a / GDF6* / P43028* / Q6KF10* / growth differentiation factor 6*ENSDARG0000005347926
gdf2 / F1QWZ4 / growth differentiation factor 2 / Q9UK05* / Q9WV56*ENSDARG0000005917326


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003146 heart jogging IGI
 biological_processGO:0003303 BMP signaling pathway involved in heart jogging IMP
 biological_processGO:0003342 proepicardium development IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IEP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IDA
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0035125 embryonic anal fin morphogenesis IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035469 determination of pancreatic left/right asymmetry IMP
 biological_processGO:0035844 cloaca development IMP
 biological_processGO:0042664 negative regulation of endodermal cell fate specification IGI
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0048264 determination of ventral identity IMP
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0060034 notochord cell differentiation IMP
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0060803 BMP signaling pathway involved in mesodermal cell fate specification IMP
 biological_processGO:0061312 BMP signaling pathway involved in heart development IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:0071910 determination of liver left/right asymmetry IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0070700 BMP receptor binding IBA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000077 tail bud tail bud aplastic , abnormal
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 ZFA:0000091 axial chorda mesoderm axial chorda mesoderm decreased size , abnormal
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 ZFA:0000112 gut gut decreased curvature , abnormal
gut immature , abnormal
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 ZFA:0000114 heart heart orientation whole organism left-right axis, abnormal
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 ZFA:0000115 heart rudiment heart rudiment cardioblast anterior-lateral migration process quality , abnormal
Show

 ZFA:0000123 liver liver orientation whole organism left-right axis, abnormal
liver duplicated , abnormal
Show

 ZFA:0000135 notochord notochord decreased diameter , abnormal
notochord cell vacuolated , abnormal
notochord cell decreased amount , abnormal
notochord increased width , abnormal
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 ZFA:0000140 pancreas pancreas orientation whole organism left-right axis, abnormal
pancreas duplicated , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
somite increased width , abnormal
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 ZFA:0000330 cloacal chamber cloacal chamber morphology , abnormal
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 ZFA:0000360 heart tube heart tube medial orientation , abnormal
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 ZFA:0000471 atrium atrium position , abnormal
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 ZFA:0001055 pronephric duct opening pronephric duct opening closed , abnormal
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 ZFA:0001058 caudal fin caudal fin decreased size , abnormal
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 ZFA:0001069 ventral fin fold ventral fin fold decreased size , abnormal
ventral fin fold absent , abnormal
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 ZFA:0001082 chordo neural hinge chordo neural hinge decreased size , abnormal
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 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
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 ZFA:0001117 post-vent region post-vent region bifurcated , abnormal
post-vent region morphology , abnormal
post-vent region decreased length , abnormal
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 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus morphology , abnormal
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 ZFA:0001724 presumptive endocardium presumptive endocardium BMP signaling pathway involved in heart development decreased process quality , abnormal
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 ZFA:0005057 epicardium epicardium hypoplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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