ENSDARG00000053479


Danio rerio

Features
Gene ID: ENSDARG00000053479
  
Biological name :gdf6a
  
Synonyms : gdf6a / growth differentiation factor 6a / P85857
  
Possible biological names infered from orthology : GDF6 / growth differentiation factor 6 / P43028 / Q6KF10
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 39125589
Gene end: 39131666
  
Corresponding Affymetrix probe sets: Dr.16432.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000069999
NCBI entrez gene - 566470     See in Manteia.
RefSeq - NM_001159994
RefSeq Peptide - NP_001153466
swissprot - P85857
ZFIN ID - ZDB-GENE-980526-373
Ensembl - ENSDARG00000053479
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GDF6ENSGALG00000035901Gallus gallus
 GDF6ENSG00000156466Homo sapiens
 Gdf6ENSMUSG00000051279Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gdf6b / A8E7N9 / growth differentiation factor 6b / GDF6* / Q6KF10* / P43028* / growth differentiation factor 6*ENSDARG0000000551059
gdf7 / growth differentiation factor 7 / P43029* / Q7Z4P5*ENSDARG0000004278447
gdf5 / growth differentiation factor 5 / P43026* / P43027*ENSDARG0000000276045
bmp2a / bone morphogenetic protein 2a / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*ENSDARG0000001340927
bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*ENSDARG0000004143027
bmp4 / bone morphogenetic protein 4 / P12644* / P21275* / Bone morphotic protein 4 *ENSDARG0000001999526
admp / anti-dorsalizing morphogenic proteinENSDARG0000002537225
bmp5 / bone morphogenetic protein 5 / P22003*ENSDARG0000010170124
bmp10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *ENSDARG0000006176924
bmp16 / bone morphogenetic protein 16ENSDARG0000010367923
bmp7b / bone morphogenetic protein 7bENSDARG0000006323023
bmp10l / bone morphogenetic protein 10, like / BMP10* / O95393* / bone morphogenetic protein 10*ENSDARG0000010923323
bmp7a / bone morphogenetic protein 7a / BMP7* / P23359* / P18075* / Bone morphotic protein 7 * / bone morphogenetic protein 7*ENSDARG0000001826023
bmp6 / bone morphogenetic protein 6 / P20722* / P22004* / Bone morphotic protein 6 *ENSDARG0000001568622
gdf2 / F1QWZ4 / growth differentiation factor 2 / Q9UK05* / Q9WV56*ENSDARG0000005917322
bmp8a / bone morphogenetic protein 8a / BMP8B* / Q7Z5Y6* / P34820* / P34821* / P55105* / Bone morphotic protein 8B * / Bone morphotic protein 8A * / bone morphogenetic protein 8b*ENSDARG0000003567722


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001895 retina homeostasis IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030510 regulation of BMP signaling pathway IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0031076 embryonic camera-type eye development IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042670 retinal cone cell differentiation IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0046552 photoreceptor cell fate commitment IMP
 biological_processGO:0048264 determination of ventral identity IMP
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048706 embryonic skeletal system development IMP
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 biological_processGO:0060219 camera-type eye photoreceptor cell differentiation IGI
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:1990009 retinal cell apoptotic process IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
brain decreased width , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer cell decreased amount , abnormal
Show

 ZFA:0000035 lens lens shape , abnormal
lens decreased size , abnormal
lens mislocalised ventrally , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer absent , abnormal
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 ZFA:0000075 spinal cord spinal cord lacks parts or has fewer parts of type motor neuron , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye quality , abnormal
eye apoptotic process increased process quality , abnormal
eye cell proliferation decreased process quality , abnormal
eye intrinsic apoptotic signaling pathway increased process quality , abnormal
Show

 ZFA:0000108 fin fin absent , abnormal
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 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer cell decreased amount , abnormal
retinal inner nuclear layer spatial pattern , abnormal
retinal inner nuclear layer increased distribution , abnormal
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 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer lacks parts or has fewer parts of type retinal cone cell , abnormal
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 ZFA:0000152 retina retina has fewer parts of type blue sensitive photoreceptor cell , abnormal
retina dorsal/ventral pattern formation process quality , abnormal
retina apoptotic , abnormal
retina decreased size , abnormal
retina GABAergic neuron mislocalised , abnormal
retina increased amount , abnormal
retina amount , ameliorated
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0000445 optic tectum optic tectum has fewer parts of type retinal ganglion cell neuron projection, abnormal
optic tectum ventral region morphology , abnormal
optic tectum innervation decreased process quality , abnormal
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 ZFA:0000708 ventrolateral optic tract ventrolateral optic tract quality , abnormal
ventrolateral optic tract agenesis , abnormal
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 ZFA:0001073 axial vasculature axial vasculature hemorrhagic , abnormal
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 ZFA:0001086 muscle pioneer muscle pioneer increased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism immobile , abnormal
whole organism colorless , abnormal
whole organism dead , abnormal
whole organism lethal (sensu genetics) , abnormal
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 ZFA:0001114 head head structure , abnormal
head degenerate , abnormal
head central region amorphous , abnormal
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 ZFA:0001117 post-vent region post-vent region structure , abnormal
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 ZFA:0001202 optic cup optic cup increased amount , abnormal
optic cup amount , ameliorated
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 ZFA:0001267 cranial vasculature cranial vasculature hemorrhagic , abnormal
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 ZFA:0001283 pupil pupil morphology , abnormal
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 ZFA:0001284 optic fissure optic fissure morphology , abnormal
optic fissure mislocalised , abnormal
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 ZFA:0001289 ciliary marginal zone ciliary marginal zone cell proliferation decreased process quality , abnormal
ciliary marginal zone increased amount , abnormal
ciliary marginal zone decreased amount , abnormal
ciliary marginal zone decreased distribution , abnormal
ciliary marginal zone decreased thickness , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage obtuse angle to ceratohyal cartilage , abnormal
ceratohyal cartilage overlap with ceratohyal cartilage , abnormal
ceratohyal cartilage mislocalised medially , abnormal
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 ZFA:0001517 ceratobranchial 2 cartilage ceratobranchial 2 cartilage orientation ceratobranchial 2 cartilage , abnormal
ceratobranchial 2 cartilage mislocalised anteriorly , abnormal
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 ZFA:0001520 ceratobranchial 1 cartilage ceratobranchial 1 cartilage orientation ceratobranchial 1 cartilage , abnormal
ceratobranchial 1 cartilage mislocalised anteriorly , abnormal
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 ZFA:0001522 hypobranchial cartilage hypobranchial cartilage decreased width , abnormal
hypobranchial cartilage notched , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature hemorrhagic , abnormal
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 ZFA:0009052 motor neuron motor neuron neuromuscular junction physical object quality , abnormal
motor neuron neuromuscular junction increased volume , abnormal
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 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell decreased amount , abnormal
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 ZFA:0009262 retinal cone cell retinal cone cell morphology , abnormal
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 ZFA:0009280 Muller cell Muller cell disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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