ENSDARG00000018260


Danio rerio

Features
Gene ID: ENSDARG00000018260
  
Biological name :bmp7a
  
Synonyms : bmp7a / bone morphogenetic protein 7a
  
Possible biological names infered from orthology : BMP7 / bone morphogenetic protein 7 / Bone morphotic protein 7 / P18075 / P23359
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 7107798
Gene end: 7147540
  
Corresponding Affymetrix probe sets: Dr.8110.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000017352
Ensembl peptide - ENSDARP00000115518
NCBI entrez gene - 30584     See in Manteia.
swissprot - F1Q926
swissprot - Q9PTF9
ZFIN ID - ZDB-GENE-000208-25
Ensembl - ENSDARG00000018260
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BMP7ENSGALG00000007668Gallus gallus
 BMP7ENSG00000101144Homo sapiens
 Bmp7ENSMUSG00000008999Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bmp7b / bone morphogenetic protein 7bENSDARG0000006323068
bmp5 / bone morphogenetic protein 5 / P22003*ENSDARG0000010170154
bmp6 / bone morphogenetic protein 6 / P20722* / P22004* / Bone morphotic protein 6 *ENSDARG0000001568653
bmp8a / bone morphogenetic protein 8a / BMP8B* / Q7Z5Y6* / P34820* / P34821* / P55105* / Bone morphotic protein 8B * / Bone morphotic protein 8A * / bone morphogenetic protein 8b*ENSDARG0000003567744
admp / anti-dorsalizing morphogenic proteinENSDARG0000002537228
bmp4 / bone morphogenetic protein 4 / P12644* / P21275* / Bone morphotic protein 4 *ENSDARG0000001999528
bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*ENSDARG0000004143027
bmp2a / bone morphogenetic protein 2a / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*ENSDARG0000001340926
bmp10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *ENSDARG0000006176925
bmp16 / bone morphogenetic protein 16ENSDARG0000010367924
gdf5 / growth differentiation factor 5 / P43026* / P43027*ENSDARG0000000276023
bmp10l / bone morphogenetic protein 10, like / BMP10* / O95393* / bone morphogenetic protein 10*ENSDARG0000010923322
gdf7 / growth differentiation factor 7 / P43029* / Q7Z4P5*ENSDARG0000004278422
gdf6a / P85857 / growth differentiation factor 6a / GDF6* / P43028* / Q6KF10* / growth differentiation factor 6*ENSDARG0000005347921
gdf2 / F1QWZ4 / growth differentiation factor 2 / Q9UK05* / Q9WV56*ENSDARG0000005917321
gdf6b / A8E7N9 / growth differentiation factor 6b / GDF6* / Q6KF10* / P43028* / growth differentiation factor 6*ENSDARG0000000551021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0003303 BMP signaling pathway involved in heart jogging IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0021703 locus ceruleus development IMP
 biological_processGO:0030509 BMP signaling pathway IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0042664 negative regulation of endodermal cell fate specification IGI
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048264 determination of ventral identity IMP
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0070700 BMP receptor binding IBA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000022 floor plate floor plate increased width , abnormal
Show

 ZFA:0000045 neural crest neural crest increased size , abnormal
Show

 ZFA:0000077 tail bud tail bud mislocalised posteriorly , abnormal
Show

 ZFA:0000115 heart rudiment heart rudiment unfused from heart rudiment , abnormal
Show

 ZFA:0000135 notochord notochord increased width , abnormal
notochord quality , abnormal
Show

 ZFA:0000138 otic placode otic placode disorganized , abnormal
otic placode aplastic , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct hypoplastic , abnormal
Show

 ZFA:0000155 somite somite circular , abnormal
somite increased width , abnormal
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm morphology , abnormal
paraxial mesoderm has extra parts of type adaxial cell , abnormal
paraxial mesoderm anterior-posterior axis decreased length , abnormal
Show

 ZFA:0000823 rhombomere 5 rhombomere 5 left side fused with rhombomere 5 right side, abnormal
Show

 ZFA:0000948 rhombomere 3 rhombomere 3 increased length , abnormal
rhombomere 3 left side fused with rhombomere 3 right side, abnormal
Show

 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
whole organism posterior region truncated , abnormal
whole organism elliptic , abnormal
whole organism posterior region wholly dorsalized , abnormal
whole organism shape , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism has extra parts of type post-vent region , abnormal
whole organism ovate , abnormal
Show

 ZFA:0001115 trunk trunk condensed , abnormal
trunk rotational curvature , abnormal
Show

 ZFA:0001117 post-vent region post-vent region aplastic , abnormal
post-vent region has extra parts of type tail bud , abnormal
post-vent region has extra parts of type notochord , abnormal
Show

 ZFA:0001135 neural tube neural tube morphology , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin mislocalised , abnormal
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 ZFA:0007035 spinal cord neural rod spinal cord neural rod neuron increased amount , abnormal
spinal cord neural rod neuron mislocalised laterally , abnormal
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 ZFA:0009004 trunk neural crest cell trunk neural crest cell decreased amount , abnormal
Show

 ZFA:0009044 blood cell blood cell decreased amount , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron decreased amount , abnormal
Show

 ZFA:0009325 erythroid lineage cell erythroid lineage cell absent , abnormal
Show

 ZFA:0009392 connective tissue cell connective tissue cell accumulation liver , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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