ENSG00000101144


Homo sapiens

Features
Gene ID: ENSG00000101144
  
Biological name :BMP7
  
Synonyms : BMP7 / bone morphogenetic protein 7 / P18075
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.31
Gene start: 57168748
Gene end: 57266629
  
Corresponding Affymetrix probe sets: 209590_at (Human Genome U133 Plus 2.0 Array)   209591_s_at (Human Genome U133 Plus 2.0 Array)   211259_s_at (Human Genome U133 Plus 2.0 Array)   211260_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379204
Ensembl peptide - ENSP00000398687
Ensembl peptide - ENSP00000390814
Ensembl peptide - ENSP00000379205
NCBI entrez gene - 655     See in Manteia.
OMIM - 112267
RefSeq - NM_001719
RefSeq Peptide - NP_001710
swissprot - A8K571
swissprot - B1AL00
swissprot - P18075
swissprot - H0Y4B5
swissprot - B1AKZ9
Ensembl - ENSG00000101144
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp7aENSDARG00000018260Danio rerio
 BMP7ENSGALG00000007668Gallus gallus
 Bmp7ENSMUSG00000008999Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMP5 / P22003 / bone morphogenetic protein 5ENSG0000011217566
BMP6 / P22004 / bone morphogenetic protein 6ENSG0000015316262
BMP8B / P34820 / bone morphogenetic protein 8bENSG0000011698548
BMP8A / Q7Z5Y6 / bone morphogenetic protein 8aENSG0000018368248
BMP4 / P12644 / bone morphogenetic protein 4ENSG0000012537830
BMP2 / P12643 / bone morphogenetic protein 2ENSG0000012584528
BMP10 / O95393 / bone morphogenetic protein 10ENSG0000016321726
GDF2 / Q9UK05 / growth differentiation factor 2ENSG0000026376126
GDF6 / Q6KF10 / growth differentiation factor 6ENSG0000015646625
GDF5 / P43026 / growth differentiation factor 5ENSG0000012596524
GDF7 / Q7Z4P5 / growth differentiation factor 7ENSG0000014386922


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001654 eye development IEA
 biological_processGO:0001656 metanephros development IEP
 biological_processGO:0001657 ureteric bud development ISS
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001823 mesonephros development IEP
 biological_processGO:0001837 epithelial to mesenchymal transition TAS
 biological_processGO:0003272 endocardial cushion formation ISS
 biological_processGO:0003344 pericardium morphogenesis ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007435 salivary gland morphogenesis IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009880 embryonic pattern specification IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010664 negative regulation of striated muscle cell apoptotic process ISS
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation TAS
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0016358 dendrite development TAS
 biological_processGO:0021502 neural fold elevation formation ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030501 positive regulation of bone mineralization IDA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0030902 hindbrain development ISS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IDA
 biological_processGO:0034504 protein localization to nucleus IDA
 biological_processGO:0035239 tube morphogenesis IEA
 biological_processGO:0042325 regulation of phosphorylation IEA
 biological_processGO:0042326 negative regulation of phosphorylation IDA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IMP
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045839 negative regulation of mitotic nuclear division IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IEA
 biological_processGO:0048738 cardiac muscle tissue development ISS
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0048762 mesenchymal cell differentiation IDA
 biological_processGO:0048812 neuron projection morphogenesis IDA
 biological_processGO:0050768 negative regulation of neurogenesis IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IEA
 biological_processGO:0060393 regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0060411 cardiac septum morphogenesis ISS
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IEA
 biological_processGO:0060485 mesenchyme development ISS
 biological_processGO:0060548 negative regulation of cell death IDA
 biological_processGO:0060686 negative regulation of prostatic bud formation IEA
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IEA
 biological_processGO:0060710 chorio-allantoic fusion ISS
 biological_processGO:0061384 heart trabecula morphogenesis ISS
 biological_processGO:0070487 monocyte aggregation IDA
 biological_processGO:0071456 cellular response to hypoxia ISS
 biological_processGO:0071773 cellular response to BMP stimulus IMP
 biological_processGO:0072040 negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis IEA
 biological_processGO:0072125 negative regulation of glomerular mesangial cell proliferation IDA
 biological_processGO:0072133 metanephric mesenchyme morphogenesis IEA
 biological_processGO:0072134 nephrogenic mesenchyme morphogenesis IEA
 biological_processGO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development IEA
 biological_processGO:1900006 positive regulation of dendrite development IDA
 biological_processGO:1900106 positive regulation of hyaluranon cable assembly IDA
 biological_processGO:1905069 allantois development ISS
 biological_processGO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
 biological_processGO:2000121 regulation of removal of superoxide radicals ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0070700 BMP receptor binding IBA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr