ENSG00000163217


Homo sapiens

Features
Gene ID: ENSG00000163217
  
Biological name :BMP10
  
Synonyms : BMP10 / bone morphogenetic protein 10 / O95393
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p13.3
Gene start: 68865481
Gene end: 68871517
  
Corresponding Affymetrix probe sets: 208292_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295379
NCBI entrez gene - 27302     See in Manteia.
OMIM - 608748
RefSeq - NM_014482
RefSeq Peptide - NP_055297
swissprot - O95393
Ensembl - ENSG00000163217
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp10ENSDARG00000061769Danio rerio
 bmp10lENSDARG00000109233Danio rerio
 BMP10ENSGALG00000000120Gallus gallus
 Bmp10ENSMUSG00000030046Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GDF2 / Q9UK05 / growth differentiation factor 2ENSG0000026376141
BMP2 / P12643 / bone morphogenetic protein 2ENSG0000012584529
BMP4 / P12644 / bone morphogenetic protein 4ENSG0000012537828
GDF6 / Q6KF10 / growth differentiation factor 6ENSG0000015646628
BMP7 / P18075 / bone morphogenetic protein 7ENSG0000010114426
BMP5 / P22003 / bone morphogenetic protein 5ENSG0000011217526
BMP6 / P22004 / bone morphogenetic protein 6ENSG0000015316225
GDF5 / P43026 / growth differentiation factor 5ENSG0000012596524
BMP8B / P34820 / bone morphogenetic protein 8bENSG0000011698524
GDF7 / Q7Z4P5 / growth differentiation factor 7ENSG0000014386923
BMP8A / Q7Z5Y6 / bone morphogenetic protein 8aENSG0000018368223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007512 adult heart development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IDA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IMP
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0030509 BMP signaling pathway TAS
 biological_processGO:0032924 activin receptor signaling pathway IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045214 sarcomere organization ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0055009 atrial cardiac muscle tissue morphogenesis ISS
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IEA
 biological_processGO:0055015 ventricular cardiac muscle cell development IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IMP
 biological_processGO:0060038 cardiac muscle cell proliferation IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060298 positive regulation of sarcomere organization IDA
 biological_processGO:0060347 heart trabecula formation IEA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:1903242 regulation of cardiac muscle hypertrophy in response to stress IDA
 biological_processGO:2000138 positive regulation of cell proliferation involved in heart morphogenesis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0030018 Z disc IDA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005179 hormone activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0031433 telethonin binding IPI
 molecular_functionGO:0033612 receptor serine/threonine kinase binding IDA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163217 BMP10 / O95393 / bone morphogenetic protein 10  / complex
 ENSG00000139567 ACVRL1 / P37023 / activin A receptor like type 1  / reaction / complex






 

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