ENSG00000143869


Homo sapiens

Features
Gene ID: ENSG00000143869
  
Biological name :GDF7
  
Synonyms : GDF7 / growth differentiation factor 7 / Q7Z4P5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p24.1
Gene start: 20666664
Gene end: 20679245
  
Corresponding Affymetrix probe sets: 214238_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000272224
NCBI entrez gene - 151449     See in Manteia.
OMIM - 604651
RefSeq - NM_182828
RefSeq Peptide - NP_878248
swissprot - Q7Z4P5
Ensembl - ENSG00000143869
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf7ENSDARG00000042784Danio rerio
 Gdf7ENSMUSG00000037660Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GDF6 / Q6KF10 / growth differentiation factor 6ENSG0000015646646
GDF5 / P43026 / growth differentiation factor 5ENSG0000012596540
BMP4 / P12644 / bone morphogenetic protein 4ENSG0000012537824
BMP2 / P12643 / bone morphogenetic protein 2ENSG0000012584524
BMP8B / P34820 / bone morphogenetic protein 8bENSG0000011698523
BMP8A / Q7Z5Y6 / bone morphogenetic protein 8aENSG0000018368222
BMP10 / O95393 / bone morphogenetic protein 10ENSG0000016321721
BMP6 / P22004 / bone morphogenetic protein 6ENSG0000015316221
BMP7 / P18075 / bone morphogenetic protein 7ENSG0000010114421
GDF2 / Q9UK05 / growth differentiation factor 2ENSG0000026376120
BMP5 / P22003 / bone morphogenetic protein 5ENSG0000011217520


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0021509 roof plate formation IEA
 biological_processGO:0021527 spinal cord association neuron differentiation IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0022612 gland morphogenesis IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0032924 activin receptor signaling pathway IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048608 reproductive structure development IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0048853 forebrain morphogenesis IEA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0060571 morphogenesis of an epithelial fold IEA
 biological_processGO:2001051 positive regulation of tendon cell differentiation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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