ENSG00000153162


Homo sapiens

Features
Gene ID: ENSG00000153162
  
Biological name :BMP6
  
Synonyms : BMP6 / bone morphogenetic protein 6 / P22004
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p24.3
Gene start: 7726797
Gene end: 7881422
  
Corresponding Affymetrix probe sets: 206176_at (Human Genome U133 Plus 2.0 Array)   215042_at (Human Genome U133 Plus 2.0 Array)   241141_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000283147
NCBI entrez gene - 654     See in Manteia.
OMIM - 112266
RefSeq - NM_001718
RefSeq Peptide - NP_001709
swissprot - P22004
Ensembl - ENSG00000153162
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp6ENSDARG00000015686Danio rerio
 BMP6ENSGALG00000012787Gallus gallus
 Bmp6ENSMUSG00000039004Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMP5 / P22003 / bone morphogenetic protein 5ENSG0000011217553
BMP7 / P18075 / bone morphogenetic protein 7ENSG0000010114452
BMP8A / Q7Z5Y6 / bone morphogenetic protein 8aENSG0000018368241
BMP8B / P34820 / bone morphogenetic protein 8bENSG0000011698541
BMP2 / P12643 / bone morphogenetic protein 2ENSG0000012584526
BMP4 / P12644 / bone morphogenetic protein 4ENSG0000012537825
GDF2 / Q9UK05 / growth differentiation factor 2ENSG0000026376122
GDF5 / P43026 / growth differentiation factor 5ENSG0000012596521
BMP10 / O95393 / bone morphogenetic protein 10ENSG0000016321721
GDF6 / Q6KF10 / growth differentiation factor 6ENSG0000015646621
GDF7 / Q7Z4P5 / growth differentiation factor 7ENSG0000014386919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001654 eye development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0003323 type B pancreatic cell development IDA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030501 positive regulation of bone mineralization IDA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030539 male genitalia development IEA
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0032349 positive regulation of aldosterone biosynthetic process IDA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0050714 positive regulation of protein secretion NAS
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0060586 multicellular organismal iron ion homeostasis IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071281 cellular response to iron ion IEA
 biological_processGO:0071773 cellular response to BMP stimulus IMP
 biological_processGO:2000105 positive regulation of DNA-dependent DNA replication NAS
 biological_processGO:2000860 positive regulation of aldosterone secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0070700 BMP receptor binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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