ENSMUSG00000039004


Mus musculus

Features
Gene ID: ENSMUSG00000039004
  
Biological name :Bmp6
  
Synonyms : Bmp6 / Bone morphotic protein 6 / P20722
  
Possible biological names infered from orthology : bone morphogenetic protein 6 / P22004
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.3
Gene start: 38345107
Gene end: 38500302
  
Corresponding Affymetrix probe sets: 10404686 (MoGene1.0st)   1450759_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152947
Ensembl peptide - ENSMUSP00000126999
NCBI entrez gene - 12161     See in Manteia.
MGI - MGI:88182
RefSeq - NM_007556
RefSeq Peptide - NP_031582
swissprot - A0A286YCE8
swissprot - P20722
Ensembl - ENSMUSG00000039004
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp6ENSDARG00000015686Danio rerio
 BMP6ENSGALG00000012787Gallus gallus
 BMP6ENSG00000153162Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp5 / P49003 / Bone morphotic protein 5 / P22003* / bone morphogenetic protein 5*ENSMUSG0000003217954
Bmp7 / P23359 / Bone morphotic protein 7 / P18075* / bone morphogenetic protein 7*ENSMUSG0000000899952
Bmp8a / P34821 / Bone morphotic protein 8A / BMP8B* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000003272641
Bmp8b / P55105 / Bone morphotic protein 8B / BMP8A* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000000238438
Bmp4 / P21275 / Bone morphotic protein 4 / P12644* / bone morphogenetic protein 4*ENSMUSG0000002183525
Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*ENSMUSG0000002735825
Bmp10 / Q9R229 / Bone morphotic protein 10 / O95393* / bone morphogenetic protein 10*ENSMUSG0000003004622
Gdf2 / Q9WV56 / Growth/differentiation factor 2 / Q9UK05*ENSMUSG0000007262522
Gdf5 / P43027 / Growth/differentiation factor 5 / P43026*ENSMUSG0000003825921
Gdf6 / P43028 / Growth/differentiation factor 6 / Q6KF10*ENSMUSG0000005127921
Gdf7 / P43029 / Growth/differentiation factor 7 / Q7Z4P5*ENSMUSG0000003766019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001654 eye development IGI
 biological_processGO:0001822 kidney development IGI
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IDA
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0006879 cellular iron ion homeostasis IMP
 biological_processGO:0006954 inflammatory response IEP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IMP
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IMP
 biological_processGO:0030539 male genitalia development IGI
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0031668 cellular response to extracellular stimulus TAS
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0032349 positive regulation of aldosterone biosynthetic process IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IMP
 biological_processGO:0060395 SMAD protein signal transduction IMP
 biological_processGO:0060586 multicellular organismal iron ion homeostasis IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071281 cellular response to iron ion IMP
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:2000860 positive regulation of aldosterone secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070700 BMP receptor binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Tg(Pomc-MAPT/Topaz)1Rck/0,Ucp2Gt(S20-3G1)Sor/Ucp2Gt(S20-3G1)Sor
Genetic Background: involves: C57BL/6 * CBA

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
Show

Allelic Composition: Tg(Pomc-MAPT/Topaz)1Rck/0,Ucp2Gt(S20-3G1)Sor/Ucp2Gt(S20-3G1)Sor
Genetic Background: involves: C57BL/6 * CBA

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(Pomc-MAPT/Topaz)1Rck/0,Ucp2Gt(S20-3G1)Sor/Ucp2Gt(S20-3G1)Sor
Genetic Background: involves: C57BL/6 * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tg(Pomc-MAPT/Topaz)1Rck/0,Ucp2Gt(S20-3G1)Sor/Ucp2Gt(S20-3G1)Sor
Genetic Background: involves: C57BL/6 * CBA

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp5se/Bmp5se,Bmp6tm1Rob/Bmp6tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0004680 small xiphoid process "reduced size of the posterior tip of the sternum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmp5se/Bmp5se,Bmp6tm1Rob/Bmp6tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egr1tm1Pch/Egr1tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bmp5se/Bmp5se,Bmp6tm1Rob/Bmp6tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0008785 abnormal sternal manubrium morphology "any structural anomaly in the cranial most segment of the sternum" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egr1tm1Pch/Egr1tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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