ENSMUSG00000038259


Mus musculus

Features
Gene ID: ENSMUSG00000038259
  
Biological name :Gdf5
  
Synonyms : Gdf5 / Growth/differentiation factor 5 / P43027
  
Possible biological names infered from orthology : P43026
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 155941023
Gene end: 155945367
  
Corresponding Affymetrix probe sets: 10488954 (MoGene1.0st)   1419139_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048079
NCBI entrez gene - 14563     See in Manteia.
MGI - MGI:95688
RefSeq - NM_008109
RefSeq Peptide - NP_032135
swissprot - P43027
Ensembl - ENSMUSG00000038259
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf5ENSDARG00000002760Danio rerio
 GDF5ENSGALG00000038355Gallus gallus
 GDF5ENSG00000125965Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gdf6 / P43028 / Growth/differentiation factor 6 / Q6KF10*ENSMUSG0000005127939
Gdf7 / P43029 / Growth/differentiation factor 7 / Q7Z4P5*ENSMUSG0000003766035
Bmp4 / P21275 / Bone morphotic protein 4 / P12644* / bone morphogenetic protein 4*ENSMUSG0000002183523
Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*ENSMUSG0000002735823
Bmp5 / P49003 / Bone morphotic protein 5 / P22003* / bone morphogenetic protein 5*ENSMUSG0000003217921
Bmp10 / Q9R229 / Bone morphotic protein 10 / O95393* / bone morphogenetic protein 10*ENSMUSG0000003004621
Bmp7 / P23359 / Bone morphotic protein 7 / P18075* / bone morphogenetic protein 7*ENSMUSG0000000899921
Bmp6 / P20722 / Bone morphotic protein 6 / P22004* / bone morphogenetic protein 6*ENSMUSG0000003900421
Bmp8a / P34821 / Bone morphotic protein 8A / BMP8B* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000003272621
Bmp8b / P55105 / Bone morphotic protein 8B / BMP8A* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000000238420
Gdf2 / Q9WV56 / Growth/differentiation factor 2 / Q9UK05*ENSMUSG0000007262519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002062 chondrocyte differentiation IGI
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IGI
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0035136 forelimb morphogenesis IMP
 biological_processGO:0035137 hindlimb morphogenesis IMP
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043932 ossification involved in bone remodeling IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0060591 chondroblast differentiation IEA
 biological_processGO:2001054 negative regulation of mesenchymal cell apoptotic process IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0036122 BMP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

Allelic Composition: Gdf5bp-J/Gdf5+
Genetic Background: involves: A/J

Allelic Composition: Bmpr1btm1Kml/Bmpr1b+,Gdf5bp-J/Gdf5+
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
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Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gdf5Rgsc451/Gdf5Rgsc451
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J * C57BL/6 * SJL

Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT stock * Swiss albino

 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dsg4lah/Dsg4lah
Genetic Background: LAH/Pas

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1btm1Kml/Bmpr1b+,Gdf5bp-J/Gdf5+
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT

Allelic Composition: Gdf5Bp-5J/Gdf5+
Genetic Background: C57BL/6J-Gdf5Bp-5J/GrsrJ

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J * C57BL/6 * SJL

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J

Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Edardl/Edardl
Genetic Background: A/H-Edardl

Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

Allelic Composition: Gdf5Bp-5J/Gdf5+
Genetic Background: C57BL/6J-Gdf5Bp-5J/GrsrJ

 MP:0002543 brachyphalangia "abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

Allelic Composition: Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J

Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gdf5Bp-5J/Gdf5+
Genetic Background: C57BL/6J-Gdf5Bp-5J/GrsrJ

Allelic Composition: Gdf5bp-6J/Gdf5bp-6J
Genetic Background: DBA/2J-Gdf5bp-6J/GrsrJ

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
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Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT

 MP:0002772 brachypodia "abnormally short feet" [J:31930, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Gdf5Bp-5J/Gdf5+
Genetic Background: C57BL/6J-Gdf5Bp-5J/GrsrJ

Allelic Composition: Gdf5bp-6J/Gdf5bp-6J
Genetic Background: DBA/2J-Gdf5bp-6J/GrsrJ

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gdf5Rgsc451/Gdf5Rgsc451
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT stock * Swiss albino

 MP:0003072 abnormal metatarsal bone morphology "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J * C57BL/6 * SJL

 MP:0003073 abnormal metacarpal bone morphology "anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J * C57BL/6 * SJL

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT

 MP:0003189 fused joints 
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Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

Allelic Composition: Gdf5Rgsc451/Gdf5Rgsc451
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT stock * Swiss albino

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0004601 abnormal vertebral spinous process "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0004602 abnormal vertebral articular process "any structural anomaly of the bilateral flat projections that arise from the junctions of the pedicles and laminae" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0004634 short metacarpal bones "reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

 MP:0004635 short metatarsal bones "reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J

Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

 MP:0004639 fused metacarpal bones "improper union of one or more of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

 MP:0004642 fused metatarsal bones "improper union of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

Allelic Composition: Gdf5Rgsc451/Gdf5Rgsc451
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Gdf5png/Gdf5png
Genetic Background: C57BL/6Apb-Gdf5png/Apb

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0005110 absent talus "absence of the bone that articulates with the tibia and fibula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

Allelic Composition: Gdf5bp/Gdf5bp
Genetic Background: Swiss albino stock

Allelic Composition: Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J

Allelic Composition: Gdf5Rgsc451/Gdf5Rgsc451
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Gdf5bp-J/Gdf5+
Genetic Background: involves: A/J

Allelic Composition: Bmpr1btm1Kml/Bmpr1b+,Gdf5bp-J/Gdf5+
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

 MP:0005353 abnormal patella morphology "anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

Allelic Composition: Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J

Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf5Rgsc451/Gdf5Rgsc451
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J

Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

 MP:0008736 micromelia "disproportionately short or small limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf5Bp-5J/Gdf5+
Genetic Background: C57BL/6J-Gdf5Bp-5J/GrsrJ

Allelic Composition: Gdf5bp-6J/Gdf5bp-6J
Genetic Background: DBA/2J-Gdf5bp-6J/GrsrJ

 MP:0008915 fused carpal bones "anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

 MP:0011504 abnormal limb long bone morphology 
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Allelic Composition: Gdf5bp-4J/Gdf5bp-4J
Genetic Background: B6.Cg-Gdf5bp-4J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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