ENSMUSG00000051279


Mus musculus

Features
Gene ID: ENSMUSG00000051279
  
Biological name :Gdf6
  
Synonyms : Gdf6 / Growth/differentiation factor 6 / P43028
  
Possible biological names infered from orthology : Q6KF10
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 9844372
Gene end: 9862345
  
Corresponding Affymetrix probe sets: 10503241 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000062884
NCBI entrez gene - 242316     See in Manteia.
MGI - MGI:95689
RefSeq - NM_013526
RefSeq Peptide - NP_038554
swissprot - A2AII0
swissprot - P43028
Ensembl - ENSMUSG00000051279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf6aENSDARG00000053479Danio rerio
 gdf6bENSDARG00000005510Danio rerio
 GDF6ENSGALG00000035901Gallus gallus
 GDF6ENSG00000156466Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gdf7 / P43029 / Growth/differentiation factor 7 / Q7Z4P5*ENSMUSG0000003766043
Gdf5 / P43027 / Growth/differentiation factor 5 / P43026*ENSMUSG0000003825943
Bmp4 / P21275 / Bone morphotic protein 4 / P12644* / bone morphogenetic protein 4*ENSMUSG0000002183526
Bmp10 / Q9R229 / Bone morphotic protein 10 / O95393* / bone morphogenetic protein 10*ENSMUSG0000003004626
Bmp8a / P34821 / Bone morphotic protein 8A / BMP8B* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000003272624
Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*ENSMUSG0000002735824
Bmp5 / P49003 / Bone morphotic protein 5 / P22003* / bone morphogenetic protein 5*ENSMUSG0000003217924
Bmp8b / P55105 / Bone morphotic protein 8B / BMP8A* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000000238423
Bmp6 / P20722 / Bone morphotic protein 6 / P22004* / bone morphogenetic protein 6*ENSMUSG0000003900423
Bmp7 / P23359 / Bone morphotic protein 7 / P18075* / bone morphogenetic protein 7*ENSMUSG0000000899923
Gdf2 / Q9WV56 / Growth/differentiation factor 2 / Q9UK05*ENSMUSG0000007262521


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0030509 BMP signaling pathway IMP
 biological_processGO:0032332 positive regulation of chondrocyte differentiation ISS
 biological_processGO:0032924 activin receptor signaling pathway ISO
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0060395 SMAD protein signal transduction ISS
 biological_processGO:1900745 positive regulation of p38MAPK cascade IMP
 biological_processGO:1990009 retinal cell apoptotic process ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
Show

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dsg4lah/Dsg4lah
Genetic Background: LAH/Pas

 MP:0003072 abnormal metatarsal bone morphology "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0003189 fused joints 
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0004601 abnormal vertebral spinous process "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0004602 abnormal vertebral articular process "any structural anomaly of the bilateral flat projections that arise from the junctions of the pedicles and laminae" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005106 abnormal incus morphology "structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005107 abnormal stapes morphology "structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005110 absent talus "absence of the bone that articulates with the tibia and fibula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdf5bp-J/Gdf5bp-J,Gdf6tm1Kng/Gdf6tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * A/J * C57BL/6J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008259 abnormal optic disc morphology "any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008372 small malleus "reduced size of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008915 fused carpal bones "anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008919 fused tarsal bones "anomaly of the eight bones of the instep of the paw/foot resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030106 small incus "reduced size of the anvil-shaped, central bone of the three auditory ossicles which articulates with the head of the malleus anteromedially and the stapes inferomedially" [https://radiopaedia.org/articles/incus]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030108 abnormal incudostapedial joint morphology "any structural anomaly of the small synovial joint located between the lenticular process on the long crus of the incus and the head of the stapes" [http://medical-dictionary.thefreedictionary.com/incudostapedial+joint]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030109 abnormal incudomalleolar joint morphology "any structural anomaly of the saddle-shaped synovial joint located between the incus and the malleus" [http://medical-dictionary.thefreedictionary.com/incudomalleolar+joint]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030123 small middle ear ossicles "reduced size of the three bones of the middle ear" [MGI:anna]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030127 small stapes "reduced size of the stirrup-shaped ossicle that is the smallest and innermost of the three auditory ossicles" [MGI:anna]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030349 absent coronal suture "failure to form the dense, fibrous connective tissue joint between the parietal bones and the frontal bone" [MGI:anna]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030400 abnormal stapes annular ligament morphology "any structural anomaly of the ring of fibrous tissue that connects the base of the stapes to the oval window (aka fenestra vestibuli) of the inner ear" [https://en.wikipedia.org/wiki/Annular_ligament_of_stapes, UBERON:0018161]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030401 absent stapes annular ligament "missing the ring of fibrous tissue that connects the base of the stapes to the oval window (aka fenestra vestibuli) of the inner ear" [MGI:anna]
Show

Allelic Composition: Gusbtm4Sly/Gusbtm4Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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