ENSMUSG00000032179


Mus musculus

Features
Gene ID: ENSMUSG00000032179
  
Biological name :Bmp5
  
Synonyms : Bmp5 / Bone morphotic protein 5 / P49003
  
Possible biological names infered from orthology : bone morphogenetic protein 5 / P22003
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 75775364
Gene end: 75900310
  
Corresponding Affymetrix probe sets: 10587231 (MoGene1.0st)   1421282_at (Mouse Genome 430 2.0 Array)   1421283_at (Mouse Genome 430 2.0 Array)   1455851_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000012281
NCBI entrez gene - 12160     See in Manteia.
MGI - MGI:88181
RefSeq - NM_007555
RefSeq Peptide - NP_031581
swissprot - P49003
Ensembl - ENSMUSG00000032179
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp5ENSDARG00000101701Danio rerio
 BMP5ENSGALG00000016293Gallus gallus
 BMP5ENSG00000112175Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp7 / P23359 / Bone morphotic protein 7 / P18075* / bone morphogenetic protein 7*ENSMUSG0000000899963
Bmp6 / P20722 / Bone morphotic protein 6 / P22004* / bone morphogenetic protein 6*ENSMUSG0000003900461
Bmp8a / P34821 / Bone morphotic protein 8A / BMP8B* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000003272647
Bmp8b / P55105 / Bone morphotic protein 8B / BMP8A* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000000238444
Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*ENSMUSG0000002735829
Bmp4 / P21275 / Bone morphotic protein 4 / P12644* / bone morphogenetic protein 4*ENSMUSG0000002183528
Gdf6 / P43028 / Growth/differentiation factor 6 / Q6KF10*ENSMUSG0000005127924
Gdf2 / Q9WV56 / Growth/differentiation factor 2 / Q9UK05*ENSMUSG0000007262524
Bmp10 / Q9R229 / Bone morphotic protein 10 / O95393* / bone morphogenetic protein 10*ENSMUSG0000003004624
Gdf5 / P43027 / Growth/differentiation factor 5 / P43026*ENSMUSG0000003825923
Gdf7 / P43029 / Growth/differentiation factor 7 / Q7Z4P5*ENSMUSG0000003766021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001503 ossification IEA
 biological_processGO:0003272 endocardial cushion formation IGI
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0003344 pericardium morphogenesis IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0010894 negative regulation of steroid biosynthetic process IEA
 biological_processGO:0021502 neural fold elevation formation IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0030539 male genitalia development IGI
 biological_processGO:0030902 hindbrain development IGI
 biological_processGO:0032348 negative regulation of aldosterone biosynthetic process IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0043583 ear development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048738 cardiac muscle tissue development IGI
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060037 pharyngeal system development IGI
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0060411 cardiac septum morphogenesis IGI
 biological_processGO:0060710 chorio-allantoic fusion IGI
 biological_processGO:0061384 heart trabecula morphogenesis IGI
 biological_processGO:0097065 anterior head development IMP
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:1905069 allantois development IGI
 biological_processGO:2000065 negative regulation of cortisol biosynthetic process IEA
 biological_processGO:2000105 positive regulation of DNA-dependent DNA replication IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0070700 BMP receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: P/J

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: NB

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: involves: C3H * P

Allelic Composition: Bmp5cfe-se8J/Bmp5cfe-se8J
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Bmp5se-4J/Bmp5se-4J
Genetic Background: B6(Cg)-Bmp5se-4J/J

Allelic Composition: Bmp5cfe-se6J/Bmp5cfe-se6J
Genetic Background: BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ

Allelic Composition: Bmp5se-15THO-I/Bmp5se-15THO-I
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se/Bmp5se-5RD300H
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se/Bmp5se-52CoS
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se-x/Bmp5se-x
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se-4CHLd/Bmp5se-4CHLd
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se-38DSD/Bmp5se-38DSD
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se/Bmp5se-32DTD
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se-30DThWb/Bmp5se-30DThWb
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se/Bmp5se-1FrThc
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se-19H/Bmp5se-19H
Genetic Background: involves: C3H/HeH

 MP:0000019 thick ears "increased width of the epidermal and cartilaginous tissue that makes up the ear" [J:65045]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0000022 abnormal ear shape "malformation of the pattern of the external ear" [J:65038]
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Allelic Composition: Myo7ash1-11J/Myo7ash1-11J
Genetic Background: C57BL/6J-Myo7ash1-11J/J

Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

Allelic Composition: Bmp5cfe-se8J/Bmp5cfe-se8J
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Bmp5se-4J/Bmp5se-4J
Genetic Background: B6(Cg)-Bmp5se-4J/J

Allelic Composition: Bmp5cfe-se6J/Bmp5cfe-se6J
Genetic Background: BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ

 MP:0000024 lowered ear position "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo7ash1-11J/Myo7ash1-11J
Genetic Background: C57BL/6J-Myo7ash1-11J/J

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Myo7ash1-11J/Myo7ash1-11J
Genetic Background: C57BL/6J-Myo7ash1-11J/J

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Tg(Pomc-MAPT/Topaz)1Rck/0,Ucp2Gt(S20-3G1)Sor/Ucp2Gt(S20-3G1)Sor
Genetic Background: involves: C57BL/6 * CBA

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: P/J

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: NB

Allelic Composition: Bmp5se/Bmp5se,Bmp6tm1Rob/Bmp6tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: involves: C3H * P

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEC/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEC/1Gn

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo7ash1-11J/Myo7ash1-11J
Genetic Background: C57BL/6J-Myo7ash1-11J/J

Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0000441 wide skull 
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Allelic Composition: Myo7ash1-11J/Myo7ash1-11J
Genetic Background: C57BL/6J-Myo7ash1-11J/J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp5se/Bmp5+
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEA/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: CBA/Ca-Bmp5se-Ca

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEA/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: CBA/Ca-Bmp5se-Ca

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: CBA/Ca-Bmp5se-Ca

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pahenu1/Pahenu2
Genetic Background: involves: 101 * C3H * BTBR

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEC/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: CBA/Ca-Bmp5se-Ca

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Myo7ash1-11J/Myo7ash1-11J
Genetic Background: C57BL/6J-Myo7ash1-11J/J

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: involves: C3H * P

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Col4a2ENU4020/Col4a2ENU4020
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Col4a2ENU4020/Col4a2ENU4020
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tg(Pomc-MAPT/Topaz)1Rck/0,Ucp2Gt(S20-3G1)Sor/Ucp2Gt(S20-3G1)Sor
Genetic Background: involves: C57BL/6 * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Tg(Pomc-MAPT/Topaz)1Rck/0,Ucp2Gt(S20-3G1)Sor/Ucp2Gt(S20-3G1)Sor
Genetic Background: involves: C57BL/6 * CBA

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se-19H
Genetic Background: involves: C3H/HeH

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1.1Tno/Apc+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo7ash1-11J/Myo7ash1-11J
Genetic Background: C57BL/6J-Myo7ash1-11J/J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: C/Gn

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: involves: C3H * P

Allelic Composition: Bmp5se-4J/Bmp5se-4J
Genetic Background: B6(Cg)-Bmp5se-4J/J

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo7ash1-11J/Myo7ash1-11J
Genetic Background: C57BL/6J-Myo7ash1-11J/J

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: C/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEC/1Gn

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0002249 abnormal larynx morphology "any structural anomaly of the most superior portion of the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Pahenu1/Pahenu2
Genetic Background: involves: 101 * C3H * BTBR

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0002256 abnormal laryngeal cartilage morphology "any structural anomaly of the cartilagenous structures that support the larynx" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: C/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0002258 abnormal cricoid cartilage morphology "any structural anomaly of the most inferior of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: C/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0002260 abnormal thyroid cartilage morphology "any structural anomaly of the largest of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: C/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEC/1Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: CBA/Ca-Bmp5se-Ca

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: C/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se/Bmp5+
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0003230 abnormal umbilical artery "malformation of the blood vessel of the umbilical cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: CBA/Ca-Bmp5se-Ca

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0003585 large ureter "increased size or length of the tube that conducts the urine from the renal pelvis to the bladder" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: CBA/Ca-Bmp5se-Ca

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: C/Gn

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: C/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0004350 long humerus "increased length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se/Bmp5+
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

Allelic Composition: Bmp5se-Ca/Bmp5+
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0004357 long tibia "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: C/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0004360 absent ulna "missing the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0004601 abnormal vertebral spinous process "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

Allelic Composition: Bmp5se/Bmp5se,Bmp6tm1Rob/Bmp6tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0004680 small xiphoid process "reduced size of the posterior tip of the sternum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp5se/Bmp5se,Bmp6tm1Rob/Bmp6tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0004695 increased length of long bones "greater end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0004880 lung cysts 
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEC/1Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0008150 decreased diameter of long bones "reduced width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0008154 decreased diameter of humerus "reduced width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEC/Gn

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se,Bmp6tm1Rob/Bmp6tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0009005 abnormal sesamoid bone of gastrocnemius morphology "any structural anomaly of the small sesamoid bones situated behind the condyles of the femur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a2ENU4020/Col4a2ENU4020
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0009914 abnormal hyoid bone lesser horn morphology "any structural anomaly of shorter and more medial of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: C/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Ab/Gn

 MP:0010031 abnormal cranium size "deviation from the average range of cranium size compared to normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0010113 abnormal sacrum morphology "any structural anomaly of the segment of the vertebral column that is formed by the fusion of five sacral vertebrae in adult humans and tailless primates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0010146 umbilical hernia "an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the umbilicus; occurs when the muscle through which blood vessels pass to feed the developing fetus fails to completely close" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", PMID:20333300]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

 MP:0010736 abnormal extraembryonic ectoderm morphology "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a2ENU4020/Col4a2ENU4020
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0010770 preweaning lethality "death anytime between fertilization and weaning (Mus: approximately 3-4 weeks of age)" [MGI:Sanger_Karp "Submission from Natasha Karp"]
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Allelic Composition: Bmp5se-20H/Bmp5se-20H
Genetic Background: involves: C3H/HeH

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Col4a2ENU4020/Col4a2ENU4020
Genetic Background: C3.D2-Col4a2ENU4020

Allelic Composition: Bmp5T27H/Bmp5T27H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Bmp5se-70FBFo/Bmp5se-70FBFo
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se-52CoS/Bmp5se-52CoS
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se-207K/Bmp5se-207K
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se-32DTD/Bmp5se-32DTD
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Col4a2ENU4020/Col4a2ENU4020
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Rasa3scat/Rasa3scat
Genetic Background: involves: 129S7/SvEvBrd * BALB/cBy

 MP:0011318 abnormal right renal artery morphology "any structural anomaly of the major vessel which arises off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supplies the right kidney with blood" [MGI:csmith]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEA/Gn

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: CBA/Ca-Bmp5se-Ca

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0011727 ectopic ovary "appearance of an ovary in a region where it is not normally found (topographical anomaly)" [MGI:csmith]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

Allelic Composition: Bmp5se-Ca/Bmp5se-Ca
Genetic Background: SEACGn.CB-Bmp5se-Ca

 MP:0011835 abnormal urogenital fold morphology "any structural anomaly of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora" [MGI:anna]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: SEAC/Gn

 MP:0011862 decreased cranium length "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0011872 absent xiphoid process "absence of the posterior tip of the sternum" [MGI:Colin_McKerlie]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0013618 decreased areal bone mineral density "reduction of the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978]
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Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0020084 short ears "reduced length of the ears" [GOC:NV]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se-15THO-I/Bmp5se-15THO-I
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se/Bmp5se-15THO-I
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se/Bmp5T27H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Bmp5se/Bmp5se-x
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Bmp5se-19H/Bmp5se-19H
Genetic Background: involves: C3H/HeH

Allelic Composition: Bmp5se/Bmp5se-19H
Genetic Background: involves: C3H/HeH

Allelic Composition: Bmp5se-20H/Bmp5se-20H
Genetic Background: involves: C3H/HeH

 MP:0030422 abnormal outer ear cartilage morphology "any structural anomaly of the elastic cartilage components of the auricles and/or external acoustic meatus" [MGI:anna]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: P/J

Allelic Composition: Bmp5se/Bmp5se
Genetic Background: involves: C3H * P

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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