ENSG00000112175


Homo sapiens

Features
Gene ID: ENSG00000112175
  
Biological name :BMP5
  
Synonyms : BMP5 / bone morphogenetic protein 5 / P22003
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p12.1
Gene start: 55753645
Gene end: 55875564
  
Corresponding Affymetrix probe sets: 205430_at (Human Genome U133 Plus 2.0 Array)   205431_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359866
NCBI entrez gene - 653     See in Manteia.
OMIM - 112265
RefSeq - XM_017011198
RefSeq - NM_021073
RefSeq - XM_005249304
RefSeq - XM_011514816
RefSeq Peptide - NP_066551
swissprot - M9VUD0
swissprot - P22003
Ensembl - ENSG00000112175
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp5ENSDARG00000101701Danio rerio
 BMP5ENSGALG00000016293Gallus gallus
 Bmp5ENSMUSG00000032179Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMP7 / P18075 / bone morphogenetic protein 7ENSG0000010114463
BMP6 / P22004 / bone morphogenetic protein 6ENSG0000015316259
BMP8B / P34820 / bone morphogenetic protein 8bENSG0000011698547
BMP8A / Q7Z5Y6 / bone morphogenetic protein 8aENSG0000018368246
BMP4 / P12644 / bone morphogenetic protein 4ENSG0000012537828
BMP2 / P12643 / bone morphogenetic protein 2ENSG0000012584528
GDF2 / Q9UK05 / growth differentiation factor 2ENSG0000026376125
BMP10 / O95393 / bone morphogenetic protein 10ENSG0000016321724
GDF6 / Q6KF10 / growth differentiation factor 6ENSG0000015646624
GDF5 / P43026 / growth differentiation factor 5ENSG0000012596523
GDF7 / Q7Z4P5 / growth differentiation factor 7ENSG0000014386920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0003272 endocardial cushion formation ISS
 biological_processGO:0003323 type B pancreatic cell development IDA
 biological_processGO:0003344 pericardium morphogenesis ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition NAS
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0010894 negative regulation of steroid biosynthetic process IDA
 biological_processGO:0021502 neural fold elevation formation ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0030539 male genitalia development IEA
 biological_processGO:0030902 hindbrain development ISS
 biological_processGO:0032348 negative regulation of aldosterone biosynthetic process IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway IDA
 biological_processGO:0043583 ear development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048738 cardiac muscle tissue development ISS
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0060411 cardiac septum morphogenesis ISS
 biological_processGO:0060710 chorio-allantoic fusion ISS
 biological_processGO:0061384 heart trabecula morphogenesis ISS
 biological_processGO:0071676 negative regulation of mononuclear cell migration NAS
 biological_processGO:0097065 anterior head development IEA
 biological_processGO:1900006 positive regulation of dendrite development IDA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors NAS
 biological_processGO:1905069 allantois development ISS
 biological_processGO:2000065 negative regulation of cortisol biosynthetic process IDA
 biological_processGO:2000105 positive regulation of DNA-dependent DNA replication IDA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0031982 vesicle ISS
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0070700 BMP receptor binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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