Manteia

ENSDARG00000059173

Danio rerio

Features

Gene ID:	ENSDARG00000059173

Biological name :	gdf2

Synonyms :	F1QWZ4 / gdf2 / growth differentiation factor 2

Possible biological names infered from orthology :	Q9UK05 / Q9WV56

Species:	Danio rerio

Chr. number:	12
Strand:	1
Band:
Gene start:	2648043
Gene end:	2651276

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000076657 NCBI entrez gene - 563287 See in Manteia. RefSeq - NM_001171586 RefSeq Peptide - NP_001165057 swissprot - F1QWZ4 ZFIN ID - ZDB-GENE-100107-1 Ensembl - ENSDARG00000059173

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
GDF2	ENSGALG00000005981	Gallus gallus
GDF2	ENSG00000263761	Homo sapiens
Gdf2	ENSMUSG00000072625	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
bmp10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *	ENSDARG00000061769	37
bmp10l / bone morphogenetic protein 10, like / BMP10* / O95393* / bone morphogenetic protein 10*	ENSDARG00000109233	30
bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*	ENSDARG00000041430	29
bmp2a / bone morphogenetic protein 2a / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*	ENSDARG00000013409	29
bmp4 / bone morphogenetic protein 4 / P12644* / P21275* / Bone morphotic protein 4 *	ENSDARG00000019995	27
bmp16 / bone morphogenetic protein 16	ENSDARG00000103679	25
gdf6a / P85857 / growth differentiation factor 6a / GDF6* / P43028* / Q6KF10* / growth differentiation factor 6*	ENSDARG00000053479	23
bmp7b / bone morphogenetic protein 7b	ENSDARG00000063230	23
admp / anti-dorsalizing morphogenic protein	ENSDARG00000025372	23
bmp8a / bone morphogenetic protein 8a / BMP8B* / Q7Z5Y6* / P34820* / P34821* / P55105* / Bone morphotic protein 8B * / Bone morphotic protein 8A * / bone morphogenetic protein 8b*	ENSDARG00000035677	23
gdf6b / A8E7N9 / growth differentiation factor 6b / GDF6* / Q6KF10* / P43028* / growth differentiation factor 6*	ENSDARG00000005510	23
bmp7a / bone morphogenetic protein 7a / BMP7* / P23359* / P18075* / Bone morphotic protein 7 * / bone morphogenetic protein 7*	ENSDARG00000018260	23
bmp6 / bone morphogenetic protein 6 / P20722* / P22004* / Bone morphotic protein 6 *	ENSDARG00000015686	23
gdf7 / growth differentiation factor 7 / P43029* / Q7Z4P5*	ENSDARG00000042784	22
gdf5 / growth differentiation factor 5 / P43026* / P43027*	ENSDARG00000002760	22
bmp5 / bone morphogenetic protein 5 / P22003*	ENSDARG00000101701	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR001111	TGF-beta, propeptide
IPR001839	Transforming growth factor-beta, C-terminal
IPR015615	Transforming growth factor-beta-related
IPR017948	Transforming growth factor beta, conserved site
IPR029034	Cystine-knot cytokine

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA
biological_process	GO:0030509	BMP signaling pathway	IBA
biological_process	GO:0042981	regulation of apoptotic process	IBA
biological_process	GO:0043408	regulation of MAPK cascade	IBA
biological_process	GO:0048468	cell development	IBA
biological_process	GO:0060395	SMAD protein signal transduction	IBA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IBA
molecular_function	GO:0005125	cytokine activity	IEA
molecular_function	GO:0005160	transforming growth factor beta receptor binding	IBA
molecular_function	GO:0008083	growth factor activity	IEA

Pathways (from Reactome)

Pathway description

Signaling by BMP

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0001094	whole organism	whole organism anterior-posterior axis decreased length , abnormal whole organism dorsal-ventral axis decreased length , abnormal	Show
ZFA:0001286	caudal vein plexus	caudal vein plexus immature , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000018179	acvrl1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *	/ reaction / complex
ENSDARG00000059173	gdf2 / F1QWZ4 / growth differentiation factor 2 / Q9UK05* / Q9WV56*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr