ENSDARG00000018179


Danio rerio

Features
Gene ID: ENSDARG00000018179
  
Biological name :acvrl1
  
Synonyms : activin A receptor like type 1 / acvrl1
  
Possible biological names infered from orthology : P37023 / Q61288 / Serine/threonine-protein kinase receptor R3
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 27835647
Gene end: 27857104
  
Corresponding Affymetrix probe sets: Dr.10629.1.S1_at (Zebrafish Array)   NM_153643_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000123002
Ensembl peptide - ENSDARP00000043461
NCBI entrez gene - 266753     See in Manteia.
RefSeq - XM_021469722
RefSeq - XM_021469724
RefSeq - XM_009296804
RefSeq - NM_153643
RefSeq Peptide - NP_705929
swissprot - Q8JFB0
swissprot - F1QH44
ZFIN ID - ZDB-GENE-021003-1
Ensembl - ENSDARG00000018179
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACVRL1ENSGALG00000035635Gallus gallus
 ACVRL1ENSG00000139567Homo sapiens
 Acvrl1ENSMUSG00000000530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
acvr1l / activin A receptor, type 1 like / ACVR1* / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSDARG0000001498654
tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*ENSDARG0000001749447
tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*ENSDARG0000004225946
acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*ENSDARG0000001896845
acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*ENSDARG0000005214244
bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000001972844
bmpr1bb / bone morphogenetic protein receptor, type IBb / BMPR1B* / O00238* / bone morphogenetic protein receptor type 1B*ENSDARG0000010274243
bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000010504543
bmpr1ba / bone morphogenetic protein receptor, type IBa / P36898* / O00238* / BMPR1B* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B ...ENSDARG0000010410043
ACVR1C / activin A receptor type 1C / Q8NER5*ENSDARG0000008617242
acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*ENSDARG0000010310829
tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSDARG0000003454129
si:dkey-101k6.5ENSDARG0000005513628
bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000002005727
acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*ENSDARG0000001118827
bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000001194127
tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*ENSDARG0000005936327
acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*ENSDARG0000010470026
acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*ENSDARG0000004442225


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0034405 response to fluid shear stress IMP
 biological_processGO:0043534 blood vessel endothelial cell migration IMP
 biological_processGO:0048264 determination of ventral identity IDA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0050880 regulation of blood vessel size IMP
 biological_processGO:0060840 artery development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000006 ball ball edematous , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta absent , abnormal
dorsal aorta increased amount , abnormal
dorsal aorta decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000099 brain vasculature brain vasculature malformed , abnormal
Show

 ZFA:0000170 basibranchial basibranchial condensed , abnormal
Show

 ZFA:0001051 caudal division of the internal carotid artery caudal division of the internal carotid artery increased size , abnormal
caudal division of the internal carotid artery decreased amount , abnormal
caudal division of the internal carotid artery amount , ameliorated
caudal division of the internal carotid artery increased width , abnormal
caudal division of the internal carotid artery blood vessel development process quality , abnormal
caudal division of the internal carotid artery blood vessel endothelial cell migration process quality , abnormal
caudal division of the internal carotid artery blood vessel endothelial cell migration increased occurrence , abnormal
caudal division of the internal carotid artery endothelial cell increased amount , abnormal
Show

 ZFA:0001052 primordial hindbrain channel primordial hindbrain channel increased size , abnormal
Show

 ZFA:0001054 lateral dorsal aorta lateral dorsal aorta amount , ameliorated
lateral dorsal aorta increased amount , abnormal
lateral dorsal aorta decreased amount , abnormal
Show

 ZFA:0001079 blood vasculature blood vasculature quality , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism morphology , abnormal
Show

 ZFA:0001114 head head edematous , abnormal
Show

 ZFA:0001267 cranial vasculature cranial vasculature malformed , abnormal
cranial vasculature artery absent , abnormal
cranial vasculature artery amount , ameliorated
Show

 ZFA:0001272 palatoquadrate arch palatoquadrate arch decreased length , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage orientation ceratohyal cartilage , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage orientation ceratobranchial cartilage , abnormal
Show

 ZFA:0005000 basal communicating artery basal communicating artery attached to primordial midbrain channel , abnormal
basal communicating artery blood vessel endothelial cell increased amount , abnormal
basal communicating artery increased size , abnormal
basal communicating artery endothelial cell increased amount , abnormal
basal communicating artery endothelial cell decreased amount , abnormal
basal communicating artery detached from primordial midbrain channel , abnormal
Show

 ZFA:0005001 posterior communicating artery posterior communicating artery blood vessel endothelial cell increased amount , abnormal
posterior communicating artery increased size , abnormal
posterior communicating artery endothelial cell increased amount , abnormal
Show

 ZFA:0005002 basilar artery basilar artery attached to primordial hindbrain channel , abnormal
basilar artery increased size , abnormal
Show

 ZFA:0005005 aortic arch 1 aortic arch 1 blood vessel development process quality , abnormal
aortic arch 1 amount , ameliorated
aortic arch 1 increased amount , abnormal
aortic arch 1 decreased amount , abnormal
aortic arch 1 morphology , abnormal
aortic arch 1 constricted , abnormal
aortic arch 1 blood vessel endothelial cell migration decreased process quality , abnormal
aortic arch 1 endothelial cell decreased amount , abnormal
aortic arch 1 blood vessel endothelial cell migration process quality , abnormal
aortic arch 1 cell migration involved in heart development decreased occurrence , abnormal
Show

 ZFA:0005017 primordial midbrain channel primordial midbrain channel dilated , abnormal
primordial midbrain channel increased size , abnormal
Show

 ZFA:0005020 central artery central artery atretic , abnormal
Show

 ZFA:0005044 optic artery optic artery absent , abnormal
optic artery amount , ameliorated
optic artery increased amount , abnormal
Show

 ZFA:0005081 internal carotid artery internal carotid artery amount , ameliorated
internal carotid artery increased amount , abnormal
internal carotid artery decreased amount , abnormal
internal carotid artery increased width , abnormal
internal carotid artery blood vessel development process quality , abnormal
internal carotid artery endothelial cell increased amount , abnormal
internal carotid artery blood vessel endothelial cell migration process quality , abnormal
Show

 ZFA:0005084 metencephalic artery metencephalic artery increased amount , abnormal
metencephalic artery decreased amount , abnormal
Show

 ZFA:0005297 cranial blood vessel cranial blood vessel dilated , abnormal
cranial blood vessel artery morphogenesis process quality , abnormal
Show

 ZFA:0005314 blood vessel blood vessel collapsed , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000061769 bmp10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *  / reaction / complex
 ENSDARG00000059173 gdf2 / F1QWZ4 / growth differentiation factor 2 / Q9UK05* / Q9WV56*  / reaction / complex
 ENSDARG00000109233 bmp10l / bone morphogenetic protein 10, like / BMP10* / O95393* / bone morphogenetic protein 10*  / reaction / complex






 

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