ENSDARG00000011188


Danio rerio

Features
Gene ID: ENSDARG00000011188
  
Biological name :acvr2aa
  
Synonyms : activin A receptor type 2Aa / acvr2aa
  
Possible biological names infered from orthology : activin A receptor type 2A / Activin receptor type-2A / ACVR2A / P27037 / P27038
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 25380758
Gene end: 25444091
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000096265
Ensembl peptide - ENSDARP00000111494
Ensembl peptide - ENSDARP00000024124
NCBI entrez gene - 553359     See in Manteia.
RefSeq - NM_001110278
RefSeq Peptide - NP_001103748
swissprot - F1R4D0
swissprot - F1QG01
swissprot - Q56E96
ZFIN ID - ZDB-GENE-980526-227
Ensembl - ENSDARG00000011188
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACVR2AENSGALG00000012444Gallus gallus
 ACVR2AENSG00000121989Homo sapiens
 Acvr2aENSMUSG00000052155Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*ENSDARG0000010470063
acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*ENSDARG0000010310859
acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*ENSDARG0000004442257
bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000002005733
bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000001194132
tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSDARG0000003454131
tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*ENSDARG0000005936330
si:dkey-101k6.5ENSDARG0000005513630
bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000001972829
acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*ENSDARG0000005214228
tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*ENSDARG0000001749428
bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000010504528
bmpr1ba / bone morphogenetic protein receptor, type IBa / P36898* / O00238* / BMPR1B* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B ...ENSDARG0000010410027
ACVR1C / activin A receptor type 1C / Q8NER5*ENSDARG0000008617227
bmpr1bb / bone morphogenetic protein receptor, type IBb / BMPR1B* / O00238* / bone morphogenetic protein receptor type 1B*ENSDARG0000010274227
acvr1l / activin A receptor, type 1 like / ACVR1* / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSDARG0000001498627
acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*ENSDARG0000001896827
tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*ENSDARG0000004225926
acvrl1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSDARG0000001817925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017194  Transforming growth factor-beta receptor, type II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Activin
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain apoptotic , abnormal
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 ZFA:0000107 eye eye swollen , abnormal
eye mislocalised laterally , abnormal
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 ZFA:0000128 midbrain midbrain apoptotic , abnormal
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 ZFA:0000191 dentary dentary shape , abnormal
dentary decreased size , abnormal
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 ZFA:0000250 opercle opercle shape , abnormal
opercle decreased size , abnormal
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 ZFA:0000270 maxilla maxilla fused with maxilla , abnormal
maxilla shape , abnormal
maxilla decreased size , abnormal
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 ZFA:0000694 ceratobranchial 5 tooth ceratobranchial 5 tooth aplastic , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism decreased length , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage structure , abnormal
Meckels cartilage fused with palatoquadrate cartilage , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased length , abnormal
mandibular arch skeleton disorganized , abnormal
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 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton decreased length , abnormal
pharyngeal arch 2 skeleton disorganized , abnormal
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 ZFA:0001279 branchiostegal ray 1 branchiostegal ray 1 aplastic , abnormal
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 ZFA:0001280 branchiostegal ray 3 branchiostegal ray 3 shape , abnormal
branchiostegal ray 3 decreased size , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage structure , abnormal
palatoquadrate cartilage fused with hyosymplectic cartilage , abnormal
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 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage structure , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage aplastic , abnormal
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 ZFA:0001517 ceratobranchial 2 cartilage ceratobranchial 2 cartilage aplastic , abnormal
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 ZFA:0001518 ceratobranchial 3 cartilage ceratobranchial 3 cartilage aplastic , abnormal
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 ZFA:0001519 ceratobranchial 4 cartilage ceratobranchial 4 cartilage aplastic , abnormal
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 ZFA:0001520 ceratobranchial 1 cartilage ceratobranchial 1 cartilage truncated , abnormal
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 ZFA:0001521 ceratobranchial 5 cartilage ceratobranchial 5 cartilage truncated , abnormal
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 ZFA:0001591 endochondral bone endochondral bone aplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000075747 zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / Q80U44* / zinc finger FYVE-type containing 16*  / complex / reaction
 ENSDARG00000103108 acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*  / complex / reaction
 ENSDARG00000011941 bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex
 ENSDARG00000011188 acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*  / reaction / complex
 ENSDARG00000019728 bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSDARG00000044422 acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*  / reaction / complex
 ENSDARG00000105045 bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSDARG00000020057 bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex
 ENSDARG00000031763 smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *  / complex / reaction
 ENSDARG00000012671 inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*  / complex / reaction
 ENSDARG00000016086 smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / reaction / complex
 ENSDARG00000018968 acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*  / reaction / complex
 ENSDARG00000027199 smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *  / reaction / complex
 ENSDARG00000021938 alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *  / reaction / complex
 ENSDARG00000037238 smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *  / reaction / complex
 ENSDARG00000052142 acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*  / reaction / complex
 ENSDARG00000040777 inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*  / complex / reaction
 ENSDARG00000038067 A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSDARG00000041430 bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / complex / reaction
 ENSDARG00000086172 ACVR1C / activin A receptor type 1C / Q8NER5*  / complex
 ENSDARG00000103892 CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*  / complex / reaction
 ENSDARG00000104700 acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*  / reaction / complex






 

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