ENSG00000121989


Homo sapiens

Features
Gene ID: ENSG00000121989
  
Biological name :ACVR2A
  
Synonyms : activin A receptor type 2A / ACVR2A / P27037
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q22.3
Gene start: 147844517
Gene end: 147930826
  
Corresponding Affymetrix probe sets: 205327_s_at (Human Genome U133 Plus 2.0 Array)   228416_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000241416
Ensembl peptide - ENSP00000384338
Ensembl peptide - ENSP00000439988
NCBI entrez gene - 92     See in Manteia.
OMIM - 102581
RefSeq - NM_001278580
RefSeq - NM_001278579
RefSeq - NM_001616
RefSeq Peptide - NP_001265508
RefSeq Peptide - NP_001265509
RefSeq Peptide - NP_001607
swissprot - P27037
Ensembl - ENSG00000121989
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acvr2aaENSDARG00000011188Danio rerio
 acvr2abENSDARG00000104700Danio rerio
 ACVR2AENSGALG00000012444Gallus gallus
 Acvr2aENSMUSG00000052155Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACVR2B / Q13705 / activin A receptor type 2BENSG0000011473967
P37173 / TGFBR2 / transforming growth factor beta receptor 2ENSG0000016351334
BMPR2 / Q13873 / bone morphogenetic protein receptor type 2ENSG0000020421734
BMPR1A / P36894 / bone morphogenetic protein receptor type 1AENSG0000010777929
BMPR1B / O00238 / bone morphogenetic protein receptor type 1BENSG0000013869629
ACVR1C / Q8NER5 / activin A receptor type 1CENSG0000012361229
ACVRL1 / P37023 / activin A receptor like type 1ENSG0000013956728
P36897 / TGFBR1 / transforming growth factor beta receptor 1ENSG0000010679928
ACVR1 / Q04771 / activin A receptor type 1ENSG0000011517028
ACVR1B / P36896 / activin A receptor type 1BENSG0000013550327
AMHR2 / Q16671 / anti-Mullerian hormone receptor type 2ENSG0000013540927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001702 gastrulation with mouth forming second IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030501 positive regulation of bone mineralization IMP
 biological_processGO:0030509 BMP signaling pathway TAS
 biological_processGO:0030510 regulation of BMP signaling pathway IEA
 biological_processGO:0032924 activin receptor signaling pathway IMP
 biological_processGO:0032927 positive regulation of activin receptor signaling pathway IDA
 biological_processGO:0042713 sperm ejaculation IEA
 biological_processGO:0043084 penile erection IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0050999 regulation of nitric-oxide synthase activity IEA
 biological_processGO:0060011 Sertoli cell proliferation IEA
 biological_processGO:0071773 cellular response to BMP stimulus IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034673 inhibin-betaglycan-ActRII complex IDA
 cellular_componentGO:0043235 receptor complex IPI
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity EXP
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity TAS
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015026 coreceptor activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017002 activin-activated receptor activity IDA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0034711 inhibin binding IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048185 activin binding IPI
 molecular_functionGO:0098821 BMP receptor activity ISS


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Regulation of signaling by NODAL
Signaling by Activin
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121989 ACVR2A / P27037 / activin A receptor type 2A  / reaction / complex
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / reaction / complex
 ENSG00000136698 CFC1 / P0CG37 / cripto, FRL-1, cryptic family 1  / complex
 ENSG00000113658 SMAD5 / Q99717 / SMAD family member 5  / complex / reaction
 ENSG00000123612 ACVR1C / Q8NER5 / activin A receptor type 1C  / complex / reaction
 ENSG00000130283 GDF1 / P27539 / growth differentiation factor 1  / reaction / complex
 ENSG00000108854 Q9HAU4 / SMURF2 / SMAD specific E3 ubiquitin protein ligase 2  / reaction / complex
 ENSG00000125845 BMP2 / P12643 / bone morphogenetic protein 2  / complex / reaction
 ENSG00000156574 NODAL / Q96S42 / nodal growth differentiation factor  / complex / reaction
 ENSG00000163083 INHBB / P09529 / inhibin beta B subunit  / reaction / complex
 ENSG00000137834 SMAD6 / O43541 / SMAD family member 6  / reaction / complex
 ENSG00000107779 BMPR1A / P36894 / bone morphogenetic protein receptor type 1A  / complex / reaction
 ENSG00000241186 TDGF1 / P13385 / teratocarcinoma-derived growth factor 1  / complex
 ENSG00000170365 SMAD1 / Q15797 / SMAD family member 1  / complex / reaction
 ENSG00000138696 BMPR1B / O00238 / bone morphogenetic protein receptor type 1B  / complex / reaction
 ENSG00000198742 Q9HCE7 / SMURF1 / SMAD specific E3 ubiquitin protein ligase 1  / reaction / complex
 ENSG00000120693 SMAD9 / O15198 / SMAD family member 9  / reaction / complex
 ENSG00000122641 INHBA / P08476 / inhibin beta A subunit  / reaction / complex
 ENSG00000039319 Q7Z3T8 / ZFYVE16 / zinc finger FYVE-type containing 16  / complex / reaction
 ENSG00000135503 ACVR1B / P36896 / activin A receptor type 1B  / reaction / complex
 ENSG00000243709 LEFTY1 / O75610 / left-right determination factor 1  / reaction / complex
 ENSG00000114739 ACVR2B / Q13705 / activin A receptor type 2B  / reaction / complex
 ENSG00000204217 BMPR2 / Q13873 / bone morphogenetic protein receptor type 2  / complex
 ENSG00000143768 LEFTY2 / O00292 / left-right determination factor 2  / complex / reaction






 

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