ENSG00000241186


Homo sapiens

Features
Gene ID: ENSG00000241186
  
Biological name :TDGF1
  
Synonyms : P13385 / TDGF1 / teratocarcinoma-derived growth factor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.31
Gene start: 46574534
Gene end: 46582463
  
Corresponding Affymetrix probe sets: 206286_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296145
Ensembl peptide - ENSP00000446375
NCBI entrez gene - 6997     See in Manteia.
OMIM - 187395
RefSeq - NM_001174136
RefSeq - NM_003212
RefSeq Peptide - NP_001167607
RefSeq Peptide - NP_003203
swissprot - P13385
swissprot - F5H1T8
Ensembl - ENSG00000241186
  
Related genetic diseases (OMIM): 187395 - Forebrain defects
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdgf1ENSDARG00000035095Danio rerio
 Tdgf1ENSMUSG00000032494Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CFC1B / P0CG36 / cripto, FRL-1, cryptic family 1BENSG0000015209321
CFC1 / P0CG37 / cripto, FRL-1, cryptic family 1ENSG0000013669821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR017047  Teratocarcinoma-derived growth factor Cripto
 IPR019011  Cryptic/Cripto, CFC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0001763 morphogenesis of a branching structure TAS
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0007507 heart development IDA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008595 anterior/posterior axis specification, embryo ISS
 biological_processGO:0009792 embryo development ending in birth or egg hatching TAS
 biological_processGO:0009966 regulation of signal transduction IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0030154 cell differentiation TAS
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030879 mammary gland development TAS
 biological_processGO:0035019 somatic stem cell population maintenance TAS
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0071354 cellular response to interleukin-6 IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0019897 extrinsic component of plasma membrane ISS
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IDA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Regulation of signaling by NODAL
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121989 ACVR2A / P27037 / activin A receptor type 2A  / complex
 ENSG00000123612 ACVR1C / Q8NER5 / activin A receptor type 1C  / complex
 ENSG00000135503 ACVR1B / P36896 / activin A receptor type 1B  / complex
 ENSG00000243709 LEFTY1 / O75610 / left-right determination factor 1  / complex / reaction
 ENSG00000130283 GDF1 / P27539 / growth differentiation factor 1  / reaction / complex
 ENSG00000241186 TDGF1 / P13385 / teratocarcinoma-derived growth factor 1  / complex
 ENSG00000156574 NODAL / Q96S42 / nodal growth differentiation factor  / reaction / complex
 ENSG00000136698 CFC1 / P0CG37 / cripto, FRL-1, cryptic family 1  / complex
 ENSG00000114739 ACVR2B / Q13705 / activin A receptor type 2B  / complex
 ENSG00000143768 LEFTY2 / O00292 / left-right determination factor 2  / reaction / complex






 

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