ENSG00000130283


Homo sapiens

Features
Gene ID: ENSG00000130283
  
Biological name :GDF1
  
Synonyms : GDF1 / growth differentiation factor 1 / P27539
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.11
Gene start: 18868545
Gene end: 18896096
  
Corresponding Affymetrix probe sets: 206397_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000247005
swissprot - P27539
Ensembl - ENSG00000130283
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf3ENSDARG00000037995Danio rerio
 GDF3ENSGALG00000003161Gallus gallus
 Cers1ENSMUSG00000087408Mus musculus
 Gdf1ENSMUSG00000109523Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CERS1 / P27544 / ceramide synthase 1ENSG00000223802100
GDF3 / Q9NR23 / growth differentiation factor 3ENSG0000018434435
GDF10 / P55107 / growth differentiation factor 10ENSG0000026652425
BMP3 / P12645 / bone morphogenetic protein 3ENSG0000015278521
NODAL / Q96S42 / nodal growth differentiation factorENSG0000015657420
INHBA / P08476 / inhibin beta A subunitENSG0000012264120
INHBE / P58166 / inhibin beta E subunitENSG0000013926920
INHBB / P09529 / inhibin beta B subunitENSG0000016308319
INHBC / P55103 / inhibin beta C subunitENSG0000017518919
BMP15 / O95972 / bone morphogenetic protein 15ENSG0000013038518
GDF15 / Q99988 / growth differentiation factor 15ENSG0000013051318
TGFB3 / P10600 / transforming growth factor beta 3ENSG0000011969917
TGFB1 / P01137 / transforming growth factor beta 1ENSG0000010532917
TGFB2 / P61812 / transforming growth factor beta 2ENSG0000009296916
GDF9 / O60383 / growth differentiation factor 9ENSG0000016440416
GDF11 / O95390 / growth differentiation factor 11ENSG0000013541416
MSTN / O14793 / myostatinENSG0000013837916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156574 NODAL / Q96S42 / nodal growth differentiation factor  / complex
 ENSG00000121989 ACVR2A / P27037 / activin A receptor type 2A  / reaction / complex
 ENSG00000123612 ACVR1C / Q8NER5 / activin A receptor type 1C  / complex / reaction
 ENSG00000135503 ACVR1B / P36896 / activin A receptor type 1B  / complex / reaction
 ENSG00000136698 CFC1 / P0CG37 / cripto, FRL-1, cryptic family 1  / reaction / complex
 ENSG00000241186 TDGF1 / P13385 / teratocarcinoma-derived growth factor 1  / reaction / complex
 ENSG00000114739 ACVR2B / Q13705 / activin A receptor type 2B  / reaction / complex






 

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