ENSG00000135414


Homo sapiens

Features
Gene ID: ENSG00000135414
  
Biological name :GDF11
  
Synonyms : GDF11 / growth differentiation factor 11 / O95390
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.2
Gene start: 55743280
Gene end: 55757278
  
Corresponding Affymetrix probe sets: 216854_at (Human Genome U133 Plus 2.0 Array)   216860_s_at (Human Genome U133 Plus 2.0 Array)   217498_at (Human Genome U133 Plus 2.0 Array)   226232_at (Human Genome U133 Plus 2.0 Array)   226234_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000448390
Ensembl peptide - ENSP00000257868
NCBI entrez gene - 10220     See in Manteia.
OMIM - 603936
RefSeq - XM_006719194
RefSeq - NM_005811
RefSeq Peptide - NP_005802
swissprot - A0A024RB20
swissprot - O95390
swissprot - H0YI30
Ensembl - ENSG00000135414
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf11ENSDARG00000044924Danio rerio
 Gdf11ENSMUSG00000025352Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MSTN / O14793 / myostatinENSG0000013837957
TGFB3 / P10600 / transforming growth factor beta 3ENSG0000011969924
TGFB1 / P01137 / transforming growth factor beta 1ENSG0000010532924
INHBA / P08476 / inhibin beta A subunitENSG0000012264123
TGFB2 / P61812 / transforming growth factor beta 2ENSG0000009296922
INHBC / P55103 / inhibin beta C subunitENSG0000017518921
INHBE / P58166 / inhibin beta E subunitENSG0000013926920
INHBB / P09529 / inhibin beta B subunitENSG0000016308320
GDF3 / Q9NR23 / growth differentiation factor 3ENSG0000018434416
GDF10 / P55107 / growth differentiation factor 10ENSG0000026652415
NODAL / Q96S42 / nodal growth differentiation factorENSG0000015657415
GDF1 / P27539 / growth differentiation factor 1ENSG0000013028315
CERS1 / P27544 / ceramide synthase 1ENSG0000022380215
BMP15 / O95972 / bone morphogenetic protein 15ENSG0000013038514
BMP3 / P12645 / bone morphogenetic protein 3ENSG0000015278514
GDF9 / O60383 / growth differentiation factor 9ENSG0000016440413
GDF15 / Q99988 / growth differentiation factor 15ENSG0000013051310


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007498 mesoderm development TAS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0021512 spinal cord anterior/posterior patterning IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060395 SMAD protein signal transduction IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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