ENSMUSG00000025352


Mus musculus

Features
Gene ID: ENSMUSG00000025352
  
Biological name :Gdf11
  
Synonyms : Gdf11 / Growth/differentiation factor 11 / Q9Z1W4
  
Possible biological names infered from orthology : O95390
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 128882295
Gene end: 128891718
  
Corresponding Affymetrix probe sets: 10373583 (MoGene1.0st)   1427723_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026408
NCBI entrez gene - 14561     See in Manteia.
MGI - MGI:1338027
RefSeq - NM_010272
RefSeq Peptide - NP_034402
swissprot - Q9Z1W4
Ensembl - ENSMUSG00000025352
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf11ENSDARG00000044924Danio rerio
 GDF11ENSG00000135414Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610058
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125324
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132423
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260323
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923922
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703521
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540520
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749220
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011716
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327915
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717115
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194315
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952315
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740815
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823813
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933512
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IGI
 biological_processGO:0001656 metanephros development IDA
 biological_processGO:0001657 ureteric bud development IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0021512 spinal cord anterior/posterior patterning IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045596 negative regulation of cell differentiation IDA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0060021 roof of mouth development IGI
 biological_processGO:0060395 SMAD protein signal transduction IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Fsttm1Zuk/Fsttm1Zuk,Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf11tm1.1Vlcg/Gdf11tm1.1Vlcg,Tg(Nanog-cre)#Vlcg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000155 asymmetric rib attachment "loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum" [J:19212]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000440 domed skull 
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000464 increased number of presacral vertebrae "greater number of the vertebrae anterior to the sacrum" [J:13069]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gdf11tm1.1Vlcg/Gdf11tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1.1Vlcg/Gdf11tm1.1Vlcg,Tg(Nanog-cre)#Vlcg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002983 increased retinal ganglion cell number "greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Fsttm1Zuk/Fsttm1Zuk,Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CD-1

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0003604 single kidney 
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004508 abnormal shoulder bone morphology "any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004645 decreased vertebrae number "a reduction from the normal number of the bony segments of the spinal column" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004650 increased lumbar vertebrae number "increased number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstn+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm2.2Sjl/Gdf11+
Genetic Background: involves: C57BL/6 * CBA * FVB

Allelic Composition: Gdf11tm2.2Sjl/Gdf11tm2.2Sjl
Genetic Background: involves: C57BL/6 * CBA * FVB

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstn+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004656 absent sacral vertebrae "absence of all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0005034 abnormal anus morphology "structural anomaly of the lower opening of the digestive tract" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Fsttm1Zuk/Fsttm1Zuk,Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CD-1

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
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Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0006095 absent amacrine cells "absence or loss of the amacrine cells, which constitute one of the three types of interneurons found in the inner nuclear layer of the mature retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:74753]
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Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008514 absent retinal inner plexiform layer "absence of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009149 decreased pancreatic acinar cell number "reduced number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0010978 absent ureteric bud "absence of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011290 decreased nephron number "reduction in the total number of filtering units of the kidney" [MGI:anna]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011364 abnormal metanephros morphology "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
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Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0012536 delayed optic fissure closure "late onset of the initiation and/or completion of closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk" [MGI:anna]
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Allelic Composition: Gdf11tm1Clf/Gdf11tm1Clf
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0030589 increased pancreatic alpha cell mass "greater total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [MGI:anna]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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