ENSMUSG00000038508


Mus musculus

Features
Gene ID: ENSMUSG00000038508
  
Biological name :Gdf15
  
Synonyms : Gdf15 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q9Z0J7
  
Possible biological names infered from orthology : growth differentiation factor 15 / Q99988
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 70629393
Gene end: 70632456
  
Corresponding Affymetrix probe sets: 10579331 (MoGene1.0st)   1418949_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003808
Ensembl peptide - ENSMUSP00000105730
NCBI entrez gene - 23886     See in Manteia.
MGI - MGI:1346047
RefSeq - XM_011242304
RefSeq - NM_001330687
RefSeq - NM_011819
RefSeq Peptide - NP_035949
RefSeq Peptide - NP_001317616
swissprot - Q9Z0J7
Ensembl - ENSMUSG00000038508
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000046278Gallus gallus
 GDF15ENSG00000130513Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011722
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740821
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952321
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194320
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933517
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327917
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132417
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749217
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717117
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125317
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540516
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923916
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823815
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260315
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535215
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703514
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610013


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction ISS
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus ISO
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Esrratm1Ics/Esrratm1Ics,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001019 abnormal L4 ganglion morphology "malformation or absence of L4 ganglion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001022 abnormal L5 ganglion morphology "malformation or absence of the L5 ganglion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Gdf15tm1Breit/Gdf15tm1Breit
Genetic Background: B6.Cg-Gdf15tm1Breit

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Gdf15tm1Breit/Gdf15tm1Breit
Genetic Background: B6.Cg-Gdf15tm1Breit

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0002752 abnormal somatic nervous system morphology "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Gdf15tm1Breit/Gdf15tm1Breit
Genetic Background: B6.Cg-Gdf15tm1Breit

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf15tm1Breit/Gdf15tm1Breit
Genetic Background: B6.Cg-Gdf15tm1Breit

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008961 abnormal basal metabolism "any anomaly in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Gdf15tm1Breit/Gdf15tm1Breit
Genetic Background: B6.Cg-Gdf15tm1Breit

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Gdf15tm1Breit/Gdf15tm1Breit
Genetic Background: B6.Cg-Gdf15tm1Breit

 MP:0009298 increased mesenteric fat pad weight 
Show

Allelic Composition: Gdf15tm1Breit/Gdf15tm1Breit
Genetic Background: B6.Cg-Gdf15tm1Breit

 MP:0009304 increased retroperitoneal fat pad weight 
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Allelic Composition: Gdf15tm1Breit/Gdf15tm1Breit
Genetic Background: B6.Cg-Gdf15tm1Breit

 MP:0009586 increased platelet aggregation "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf15tm1Breit/Gdf15tm1Breit
Genetic Background: B6.Cg-Gdf15tm1Breit

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gdf15tm1Breit/Gdf15tm1Breit
Genetic Background: B6.Cg-Gdf15tm1Breit

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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