ENSMUSG00000039239


Mus musculus

Features
Gene ID: ENSMUSG00000039239
  
Biological name :Tgfb2
  
Synonyms : P27090 / Tgfb2 / Transforming growth factor beta-2 Latency-associated peptide
  
Possible biological names infered from orthology : P61812 / transforming growth factor beta 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H5
Gene start: 186622792
Gene end: 186705989
  
Corresponding Affymetrix probe sets: 10360920 (MoGene1.0st)   1423250_a_at (Mouse Genome 430 2.0 Array)   1438303_at (Mouse Genome 430 2.0 Array)   1450922_a_at (Mouse Genome 430 2.0 Array)   1450923_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043849
Ensembl peptide - ENSMUSP00000142149
NCBI entrez gene - 21808     See in Manteia.
MGI - MGI:98726
RefSeq - XM_006497136
RefSeq - NM_009367
RefSeq - XM_006497135
RefSeq Peptide - NP_033393
RefSeq Peptide - NP_001316036
swissprot - P27090
swissprot - A0A0A6YXU9
Ensembl - ENSMUSG00000039239
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgfb2ENSDARG00000027087Danio rerio
 TGFB2ENSGALG00000009612Gallus gallus
 TGFB2ENSG00000092969Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125353
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260341
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610023
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535220
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132420
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749218
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703518
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717117
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540516
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011715
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194315
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952314
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740814
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327913
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823813
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933511
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR003940  Transforming growth factor, beta 2
 IPR015615  Transforming growth factor-beta-related
 IPR016319  Transforming growth factor-beta
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001502 cartilage condensation IGI
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001654 eye development IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003148 outflow tract septum morphogenesis IMP
 biological_processGO:0003149 membranous septum morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis TAS
 biological_processGO:0003179 heart valve morphogenesis IMP
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 biological_processGO:0003184 pulmonary valve morphogenesis IMP
 biological_processGO:0003203 endocardial cushion morphogenesis IMP
 biological_processGO:0003214 cardiac left ventricle morphogenesis TAS
 biological_processGO:0003215 cardiac right ventricle morphogenesis TAS
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0003274 endocardial cushion fusion IMP
 biological_processGO:0003289 atrial septum primum morphogenesis IMP
 biological_processGO:0003407 neural retina development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007435 salivary gland morphogenesis IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008347 glial cell migration IEA
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010002 cardioblast differentiation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010693 negative regulation of alkaline phosphatase activity IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0010936 negative regulation of macrophage cytokine production IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016049 cell growth IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0030593 neutrophil chemotaxis ISS
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IEA
 biological_processGO:0032909 regulation of transforming growth factor beta2 production IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IDA
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0035910 ascending aorta morphogenesis IMP
 biological_processGO:0042060 wound healing ISS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042416 dopamine biosynthetic process IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0045617 negative regulation of keratinocyte differentiation NAS
 biological_processGO:0045726 positive regulation of integrin biosynthetic process IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045787 positive regulation of cell cycle IMP
 biological_processGO:0045823 positive regulation of heart contraction IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IMP
 biological_processGO:0048103 somatic stem cell division IDA
 biological_processGO:0048566 embryonic digestive tract development IEA
 biological_processGO:0048663 neuron fate commitment IDA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050778 positive regulation of immune response ISS
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051794 regulation of timing of catagen IEA
 biological_processGO:0051795 positive regulation of timing of catagen IEA
 biological_processGO:0051891 positive regulation of cardioblast differentiation IEA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060038 cardiac muscle cell proliferation IEA
 biological_processGO:0060065 uterus development IMP
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IEA
 biological_processGO:0060325 face morphogenesis IEP
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0060412 ventricular septum morphogenesis TAS
 biological_processGO:0060413 atrial septum morphogenesis IMP
 biological_processGO:0061037 negative regulation of cartilage development IMP
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IMP
 biological_processGO:0070237 positive regulation of activation-induced cell death of T cells IDA
 biological_processGO:0090091 positive regulation of extracellular matrix disassembly IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IDA
 biological_processGO:1902256 regulation of apoptotic process involved in outflow tract morphogenesis IMP
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903053 regulation of extracellular matrix organization IMP
 biological_processGO:1903701 substantia propria of cornea development IMP
 biological_processGO:1904426 positive regulation of GTP binding IDA
 biological_processGO:1904888 cranial skeletal system development IMP
 biological_processGO:1905006 negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0034714 type III transforming growth factor beta receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gulotm1Mae/Gulotm1Mae
Genetic Background: involves: C57BL/6

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Gulotm1Mae/Gulotm1Mae
Genetic Background: involves: C57BL/6

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000299 failure of endocardial cushion closure "failure of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal to fuse to form the valves between the right and left atrioventricular orifices" [J:29971]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000430 absent maxillary shelf "missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gulotm1Mae/Gulotm1Mae
Genetic Background: involves: C57BL/6

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001169 abnormal bulbourethral gland morphology "malformed gland in males that lies along the prostate gland and secretes a fluid component of the seminal fluid into the urethra " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:54465, J:63764]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001170 bulbourethral gland hyperplasia "increased cell number in the bulbourethral gland" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001307 fused cornea/lens "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gulotm1Mae/Gulotm1Mae
Genetic Background: involves: C57BL/6

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001329 retina hyperplasia "greater than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003092 reduced corneal stroma thickness "reduced width of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003094 abnormal posterior stroma morphology "structural anomaly of the posterior segment of the lamellated connective tissue layer of the cornea" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003168 abnormal scala vestibuli morphology "any malformation or absence of the division of the spiral canal of the cochlea lying on the apical side of the spiral lamina and vestibular membrane" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003958 heart valve hyperplasia "increased number of cells of the heart valves, leading to increased size or bulk" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:60214]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004282 retrognathia "abnormal posterior positioning of one or both jaws, particularly the mandible, relative to the facial skeleton and soft tissues" [J:41682, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004283 absent corneal endothelium "absence of the single layer of large flattened cells that cover the surface of the cornea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004285 absent Descemet membrane "absence of the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea" [J:4605, J:73681, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004304 absent spiral limbus "absence of the border of the spiral lamina, i.e. the thickened periosteum covering the upper plate of the bony spiral lamina of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004307 absent Rosenthal canal "absence of the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004377 small frontal bone "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004384 small interparietal bone "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004418 small parietal bone "reduced size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004422 small temporal bone "reduced size of the large, irregular bone located at the base and side of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004440 absent occipital bone "absence of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004454 absent pterygoid process "absence of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004458 absent alisphenoid bone "absence of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004483 absent interdental cells "absence of the long, spindle-shaped cells arranged in parallel rows, oriented with their vertical axis perpendicular to the luminal surface of the spiral limbus; they secrete potassium ions into the endolymph and secrete the tectorial membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004627 abnormal trochanter morphology "any structural anomaly of the bony prominences near the upper extremity of the femur; there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third); these normally serve as attachment points for hip and thigh muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004913 absent mandibular angle "absence of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005198 abnormal aqueous drainage system morphology "anomalies in the structures associated with drainage of the aqueous humor from the eye, these include the trabecular meshwork, Schlemm s canal, the uveoscleral network, and the aqueous veins " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ext1tm1Yama/Ext1tm1Yama
Genetic Background: B6.129S5-Ext1tm1Yama

 MP:0005203 abnormal trabecular meshwork morphology "structural anomaly in the porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ext1tm1Yama/Ext1tm1Yama
Genetic Background: B6.129S5-Ext1tm1Yama

 MP:0005204 abnormal canal of Schlemm morphology "structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ext1tm1Yama/Ext1tm1Yama
Genetic Background: B6.129S5-Ext1tm1Yama

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005208 abnormal iris stroma morphology "structural anomaly of the lamellated connective tissue of the iris" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ext1tm1Yama/Ext1tm1Yama
Genetic Background: B6.129S5-Ext1tm1Yama

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005297 spina bifida occulta "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005299 abnormal eye posterior chamber "anomaly of the ringlike space, filled with aqueous humor, between the iris/pupil anteriorly and the lens and ciliary body posteriorly" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005304 cystic bulbourethral gland "presence of membrane-lined sacs contatining gas, fluid, or semisolid matter in the gland in males that lies along the prostate gland and secretes a fluid component of the seminal fluid into the urethra " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005305 coagulating gland hyperplasia "increased number of normal cells in the anterior lobe of the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Aebp1tm1Hsro/Aebp1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006072 abnormal retinal apoptosis "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0006200 vitreous body deposition "abnormal accumulation of material in the vitreous body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0006278 aortic aneurysm "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Fbn1tm1Hcd/Fbn1+,Tgfb2tm1Doe/Tgfb2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008884 abnormal enterocyte apoptosis "change in the timing or the number of enterocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009085 abnormal uterine horn morphology "any structural anomaly of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet; uterine horns are anterior Mullerian duct-derived structures" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009621 primary vitreous hyperplasia "overdevelopment or increased size of the primary vitreous, usually due an increased number of cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmn1tm2Made/Fmn1+,Grem1tm1Azun/Grem1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn2atm1(GFP)Cjs/Cdkn2atm1(GFP)Cjs,Tgfb2tm1Doe/Tgfb2tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Cdkn2atm1(GFP)Cjs/Cdkn2atm1(GFP)Cjs,Tgfb2tm1Doe/Tgfb2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Cdkn2atm1Sxs/Cdkn2a+,Tgfb2tm1Doe/Tgfb2tm1Doe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn2atm1Cjs/Cdkn2a+,Tgfb2tm1Doe/Tgfb2tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009866 abnormal aorta wall morphology "any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Fbn1tm1Hcd/Fbn1+,Tgfb2tm1Doe/Tgfb2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009874 abnormal interdigital cell death "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010099 abnormal thoracic cage shape "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010224 abnormal heart ventricle outflow tract morphology "any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010413 complete atrioventricular septal defect "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010419 inlet ventricular septal defect "abnormal communications between the two lower chambers of the heart, located posterior to the septal leaflet of the tricuspid valve and which are not associated with defects of the atrioventricular valves" [http://emedicine.medscape.com]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010433 double inlet heart left ventricle "congenital heart defect in which both atriums are connected to the left ventricle, with a hypoplastic right ventricle often present, which may be on the opposite side of the heart to the usua" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010460 pulmonary artery hypoplasia "underdevelopment or reduced size of the artery that arises from the right ventricle and conveys unaerated blood to the lungs, usually due to reduced cell number" [MESH:A07.231.114.715]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010465 aberrant origin of the right subclavian artery "the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010469 ascending aorta hypoplasia "underdevelopment or reduced size of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010485 aortic arch hypoplasia "underdevelopment or reduced size of the aortic arch, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010572 persistent right dorsal aorta "persistence of the right dorsal aorta after development; the right dorsal aorta normally regresses but when it persists, a double aortic arch develops; if the left dorsal aorta also regresses, a right aortic arch forms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010593 thick aortic valve cusps "an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010605 thick pulmonary valve cusps "an increase in the ratio of the pulmonary valve cusp thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010610 patent aortic valve "the aortic valve remains open during the cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010611 patent pulmonary valve "the pulmonary valve remains open during the cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010620 thick mitral valve 
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010629 thick tricuspid valve 
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011362 ectopic adrenal gland "an adrenal gland located outside of its normal position" [MGI:anna]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011410 ectopic testis "one or both of the testes located outside the normal pathway of descent into the scrotum" [MGI:anna]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
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Allelic Composition: Aebp1tm1Hsro/Aebp1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011575 dilated aorta bulb "the luminal space of the aorta bulb is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Fbn1tm1Hcd/Fbn1+,Tgfb2tm1Doe/Tgfb2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011781 abnormal bulbourethral gland physiology "any functional anomaly of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, which produce a clear, salty, viscous secretion known as pre-ejaculate (aka as pre-ejaculatory fluid, preseminal fluid, or Cowper s fluid) upon sexual stimulation; this fluid is believed to lubricate the urethra for spermatozoa to pass through and neutralize traces of acidic urine in the urethra" [MGI:anna]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0030006 decreased retinal apoptosis "decrease in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0030258 small mandibular condyloid process "reduced size of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:anna]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0030283 small mandibular coronoid process "reduced size of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:anna]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0030388 large fontanelles "an abnormally increased size of one or more fontanelles for age-related norms, generally resulting from delayed or incomplete fontanelle closure" [HP:0000239, MGI:anna]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001870 Ltbp1 / Q8CG19 / Latent-transforming growth factor beta-binding protein 1 / Q14766*  / reaction / complex
 ENSMUSG00000039239 Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*  / complex
 ENSMUSG00000024940 Ltbp3 / latent transforming growth factor beta binding protein 3 / Q9NS15*  / complex / reaction






 

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