ENSMUSG00000018238


Mus musculus

Features
Gene ID: ENSMUSG00000018238
  
Biological name :Gdf9
  
Synonyms : Gdf9 / Growth/differentiation factor 9 / Q07105
  
Possible biological names infered from orthology : O60383
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 53431023
Gene end: 53437904
  
Corresponding Affymetrix probe sets: 10376004 (MoGene1.0st)   1448120_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018382
NCBI entrez gene - 14566     See in Manteia.
MGI - MGI:95692
RefSeq - XM_006532220
RefSeq - NM_008110
RefSeq Peptide - NP_032136
swissprot - Q07105
swissprot - Q3UWR9
Ensembl - ENSMUSG00000018238
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf9ENSDARG00000003229Danio rerio
 GDF9ENSGALG00000028407Gallus gallus
 GDF9ENSG00000164404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327926
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194316
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717115
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933514
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011714
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132414
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125314
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923913
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749212
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540512
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535212
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703512
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952312
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610012
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740812
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260312
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850810


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR015617  Growth differentiation factor-9
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001555 oocyte growth IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:2000870 regulation of progesterone secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
Show

Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003696 abnormal zona pellucida "anomaly or absence of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009374 failure of cumulus expansion "complete inability of the cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009433 polyovular ovarian follicle "an ovarian follicle containing more than one oocyte (ovum)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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