ENSMUSG00000037171


Mus musculus

Features
Gene ID: ENSMUSG00000037171
  
Biological name :Nodal
  
Synonyms : Nodal / P43021
  
Possible biological names infered from orthology : nodal growth differentiation factor / Q96S42
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 61417972
Gene end: 61425338
  
Corresponding Affymetrix probe sets: 10363481 (MoGene1.0st)   1422057_at (Mouse Genome 430 2.0 Array)   1422058_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039653
NCBI entrez gene - 18119     See in Manteia.
MGI - MGI:97359
RefSeq - NM_013611
RefSeq Peptide - NP_038639
swissprot - P43021
Ensembl - ENSMUSG00000037171
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndr1ENSDARG00000057096Danio rerio
 ndr2ENSDARG00000101279Danio rerio
 spawENSDARG00000014309Danio rerio
 ENSGALG00000003209Gallus gallus
 NODALENSG00000156574Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749223
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132423
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923921
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703521
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011721
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194321
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740820
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952320
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125320
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540519
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260319
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327919
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933518
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823818
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610018
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535217
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850814


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0001707 mesoderm formation TAS
 biological_processGO:0001829 trophectodermal cell differentiation IDA
 biological_processGO:0001831 trophectodermal cellular morphogenesis IMP
 biological_processGO:0001842 neural fold formation IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0001893 maternal placenta development IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001947 heart looping IGI
 biological_processGO:0002085 inhibition of neuroepithelial cell differentiation IMP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry TAS
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0009948 anterior/posterior axis specification IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0009966 regulation of signal transduction IDA
 biological_processGO:0010085 polarity specification of proximal/distal axis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010470 regulation of gastrulation IGI
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010721 negative regulation of cell development IMP
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0022409 positive regulation of cell-cell adhesion IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0032927 positive regulation of activin receptor signaling pathway IEA
 biological_processGO:0033505 floor plate morphogenesis IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0038092 nodal signaling pathway IMP
 biological_processGO:0042074 cell migration involved in gastrulation IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045596 negative regulation of cell differentiation IDA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048327 axial mesodermal cell fate specification IMP
 biological_processGO:0048382 mesendoderm development IEA
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048729 tissue morphogenesis IMP
 biological_processGO:0048859 formation of anatomical boundary IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0055123 digestive system development IMP
 biological_processGO:0060136 embryonic process involved in female pregnancy IMP
 biological_processGO:0060137 maternal process involved in parturition IMP
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IEA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0060460 left lung morphogenesis IMP
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IEA
 biological_processGO:0060802 epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090009 primitive streak formation IGI
 biological_processGO:0090010 transforming growth factor beta receptor signaling pathway involved in primitive streak formation IMP
 biological_processGO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IMP
 biological_processGO:1901164 negative regulation of trophoblast cell migration IEA
 biological_processGO:1901383 negative regulation of chorionic trophoblast cell proliferation IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0048018 receptor ligand activity IDA
 molecular_functionGO:0070698 type I activin receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Smad3tm1Xfw/Smad3+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1

Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Nodaltm2Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

Allelic Composition: Nodaltm1Mku/Nodaltm1Mku,Mesp1tm2(cre)Ysa/Mesp1+,Tg(Pitx2-lacZ)1Mbf/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Acvr2btm1Enl/Acvr2b+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Col2a1tm1.1Ksec/Col2a1tm1.1Ksec,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

Allelic Composition: Col2a1tm1.1Ksec/Col2a1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000508 right-sided isomerism "the relative symmetry of the organs of the thorax and abdomen as indicated by both atria displaying the morphology of the right atrium" [J:58530, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm2Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Nodaltm2Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm6Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pon1tm1Lus/Pon1tm1Lus
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pon1tm1Lus/Pon1tm1Lus
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0000690 absent spleen "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku
Genetic Background: involves: 129S1/Sv

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Nodaltm1Rob/Nodal+,Smad2tm1.1Epb/Smad2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tbptm1.1Ees/Tbptm1.1Ees
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Rob/Nodaltm5Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Nodaltm1Rob/Nodaltm5Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

Allelic Composition: Nodaltm1Rob/Nodaltm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0001705 abnormal proximal-distal axis patterning "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0001710 absent amniotic folds "failure of amnion to form involutions" [J:40594]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

Allelic Composition: Nodaltm1Rob/Nodaltm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Nodaltm1.1Dbc/Nodaltm1.1Dbc
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eomestm1.1Rob/Eomestm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

Allelic Composition: Nodaltm1Rob/Nodaltm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Nodaltm1Rob/Nodaltm5Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

Allelic Composition: Nodaltm1Rob/Nodaltm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

Allelic Composition: Nodaltm1Rob/Nodaltm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Nodaltm1.1Hmd/Nodaltm1.1Hmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm4Rob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Nodaltm3Rob/Nodaltm3Rob
Genetic Background: Not Specified

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku
Genetic Background: involves: 129S1/Sv

Allelic Composition: Nodaltm1Mku/Nodaltm1Mku
Genetic Background: involves: 129S1/Sv

 MP:0002174 abnormal gastrulation movements "failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:52418]
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Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1.1Dbc/Nodaltm1.1Dbc
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0002239 abnormal nasal septum morphology "any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

 MP:0002584 small ectoplacental cone 
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0002767 situs ambiguus "abnormal organ position" [J:62608]
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Allelic Composition: Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002844 aortic hypertrophy "increase in the bulk size of the aorta" [RGD:Rat Genome Database submission]
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Allelic Composition: Nodaltm2Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Smad3tm1Xfw/Smad3+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Nodaltm1Rob/Nodal+,Smad2tm1.1Epb/Smad2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm6Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv

 MP:0004190 abnormal direction of embryo turning "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Foxa2tm1Jrt/Foxa2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Dand5tm1Belo/Dand5tm1Belo,Nodaltm1.1Mku/Nodal+
Genetic Background: involves: 129/Ola * C57BL/6J

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm6Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0004387 abnormal prechordal plate morphology "any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0004388 absent prechordal plate "absence of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004714 truncated notochord "notochord morphology that terminates abruptly as if having an end or point cut off" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Nodaltm1Rob/Nodal+,Smad2tm1.1Epb/Smad2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
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Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006061 right atrial isomerism "altered asymmetric patterning of the atria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm2Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0006290 proboscis "a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1Rob/Nodal+,Smad2tm1.1Epb/Smad2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ano1tm1.1Jwo/Ano1tm1.1Jwo,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0008530 abnormal rostral-caudal patterning of the somites "anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0008533 abnormal anterior visceral endoderm "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0008786 abnormal hindgut morphology "any structural anomaly of the caudal portion of the primitive digestive tube of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1Rob/Nodal+,Smad2tm1.1Epb/Smad2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

 MP:0008926 abnormal anterior definitive endoderm morphology "any structural anomaly of the mesendoderm which first migrates from the node and which gives rise to the gut" [PMID:12464432]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0009266 abnormal mesendoderm development "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nodaltm1.1Dbc/Nodaltm1.1Dbc
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Nodaltm2Rob/Nodaltm2Rob
Genetic Background: 129S(Cg)-Nodaltm2Rob

Allelic Composition: Nodaltm2Rob/Nodal+,Zic2Ku/Zic2Ku
Genetic Background: 129S.Cg-Nodaltm2Rob Zic2Ku

 MP:0009331 absent primitive node "absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm1Mku
Genetic Background: involves: 129S1/Sv

 MP:0009905 absent tongue "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0010126 abnormal distal visceral endoderm morphology "any structural anomaly of the precursors of the anterior visceral endoderm that arises at the distal tip of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17387317]
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Allelic Composition: Nodaltm1Rob/Nodaltm5Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010335 fused first branchial arch "the first arch fails to fully divide along the midline" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0010406 absent atrial septum "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm6Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0010736 abnormal extraembryonic ectoderm morphology "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0010807 abnormal stomach position or orientation "the stomach is displaced from the normal left-sided position and/or orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Nodaltm4Rob/Nodaltm4Rob
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

Allelic Composition: Nodaltm1Rob/Nodaltm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Nodaltm1.1Dbc/Nodaltm1.1Dbc
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Lefty2tm1Hmd/Lefty2tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6Cr

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nodaltm2Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

Allelic Composition: Nodaltm4Rob/Nodaltm4Rob
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nodaltm1Hmd/Nodaltm1Hmd
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0011203 abnormal parietal yolk sac morphology "any structural anomaly of the tissue that consists of two cellular layers (parietal endoderm and trophoblast) separated by a relatively thick nonvascular basement membrane (Reichert s membrane), and acts as a protective layer to supports and facilitates transport of nutrients between the uterine tissue and the yolk sac cavity" [PMID:1150659, PMID:21123814]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0011206 absent visceral yolk sac "absence of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo" [ISBN10:9780123364258, PMID:21123814]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0011255 abnormal anterior visceral endoderm cell migration "any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]
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Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0011523 thin placenta labyrinth "decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm1Mku
Genetic Background: involves: 129S1/Sv

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0012081 absent heart tube "absence of the primitive epithelial cardiac tube before the division into the chambers of the mature heart" [MGI:anna]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm6Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0012083 absent foregut "absence of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder" [MGI:anna]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0012084 truncated foregut "shortened foregut that terminates abruptly as if having an end or point cut off" [MGI:anna]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0012087 absent midbrain "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0012098 increased spongiotrophoblast size "greater size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm1Mku
Genetic Background: involves: 129S1/Sv

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Acvr2atm1Hsch/Acvr2atm1Hsch,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0012156 rostral-caudal axis duplication "partial or complete duplication of rostral-caudal axis structures" [MGI:anna]
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Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Eomestm1Rob/Eomes+,Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Nodaltm2Rob/Nodaltm2Rob
Genetic Background: 129S(Cg)-Nodaltm2Rob

Allelic Composition: Nodaltm2Rob/Nodal+,Zic2Ku/Zic2Ku
Genetic Background: 129S.Cg-Nodaltm2Rob Zic2Ku

Allelic Composition: Nodaltm2Rob/Nodaltm2Rob,Zic2Ku/Zic2Ku
Genetic Background: 129S.Cg-Nodaltm2Rob Zic2Ku

Allelic Composition: Nodaltm2Rob/Nodaltm2Rob,Zic2Ku/Zic2+
Genetic Background: 129S.Cg-Nodaltm2Rob Zic2Ku

Allelic Composition: Nodaltm1Rob/Nodal+,Zic2Ku/Zic2Ku
Genetic Background: 129S.Cg-Nodaltm1Rob Zic2Ku

 MP:0012160 expanded anterior visceral endoderm "the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue occupies a greater area in the extraembryonic region" [MGI:anna]
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Allelic Composition: Ptk7chz/Ptk7+,Vangl2Lp/Vangl2+
Genetic Background: involves: A * BALB/cAnN * C3H/HeH

 MP:0012176 abnormal head development "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

 MP:0012181 increased somite number "increase in the average number of somites formed relative to littermates or other controls" [MGI:anna]
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Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0012515 abnormal heart apex morphology "any structural anomaly of the lowest superficial part of the heart, normally directed downward, forward, and to the left, and overlapped by the left lung and pleura; the heart apex is formed by the inferolateral part of the left ventricle and responsible for regulating ventricle contraction" [MGI:anna]
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Allelic Composition: Nodaltm2Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0012675 enlarged floor plate "increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]
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Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0012706 decreased embryonic neuroepithelial cell proliferation "decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0012724 failure of head fold formation "inability to form the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; the head fold constitutes the first body fold, and initiates brain, foregut and heart development" [MGI:anna]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
Genetic Background: 129S/SvEv-NodalTgR(MPSVNeo)413.dRob

 MP:0030198 nasal septum hypoplasia "underdevelopment or reduced size of the nasal septum, usually due to a reduced number of cells" [MGI:anna]
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Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000532 Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*  / complex / reaction
 ENSMUSG00000026124 Cfc1 / P97766 / Cryptic protein / CFC1B* / P0CG36* / P0CG37* / cripto, FRL-1, cryptic family 1* / cripto, FRL-1, cryptic family 1B*  / reaction / complex
 ENSMUSG00000026834 Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*  / complex / reaction
 ENSMUSG00000038793 Q64280 / Lefty1 / Left-right determination factor 1 / LEFTY2* / O00292* / O75610* / left-right determination factor 2*  / reaction / complex
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / reaction / complex
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / reaction / complex
 ENSMUSG00000109523 Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*  / complex
 ENSMUSG00000037171 Nodal / P43021 / Q96S42* / nodal growth differentiation factor*  / complex
 ENSMUSG00000066652 P57785 / Lefty2 / Left-right determination factor 2 / LEFTY1* / O00292* / O75610* / left-right determination factor 1*  / complex / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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