ENSMUSG00000021253


Mus musculus

Features
Gene ID: ENSMUSG00000021253
  
Biological name :Tgfb3
  
Synonyms : Tgfb3 / transforming growth factor, beta 3
  
Possible biological names infered from orthology : P10600
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D2
Gene start: 86056745
Gene end: 86079041
  
Corresponding Affymetrix probe sets: 10401673 (MoGene1.0st)   1417455_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003687
NCBI entrez gene - 21809     See in Manteia.
MGI - MGI:98727
RefSeq - NM_009368
RefSeq Peptide - NP_033394
swissprot - Q91YU7
Ensembl - ENSMUSG00000021253
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgfb3ENSDARG00000019367Danio rerio
 TGFB3ENSGALG00000010346Gallus gallus
 TGFB3ENSG00000119699Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923957
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260346
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610025
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535223
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132422
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749219
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703519
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952317
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717117
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011717
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740817
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194316
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540516
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823815
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327914
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933513
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850813


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR015618  Transforming growth factor beta-3
 IPR016319  Transforming growth factor-beta
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007435 salivary gland morphogenesis IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010936 negative regulation of macrophage cytokine production IEA
 biological_processGO:0016049 cell growth IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0034616 response to laminar fluid shear stress IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0043932 ossification involved in bone remodeling IEA
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048702 embryonic neurocranium morphogenesis IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0060364 frontal suture morphogenesis IEA
 biological_processGO:0070483 detection of hypoxia IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1905075 positive regulation of occluding junction disassembly IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding IEA
 molecular_functionGO:0034714 type III transforming growth factor beta receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

Allelic Composition: Tgfb3tm1(cre)Vk/Tgfb3tm1(cre)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

Allelic Composition: Tgfb3tm1Moaz/Tgfb3tm1.1Moaz,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gulotm1Mae/Gulotm1Mae
Genetic Background: involves: C57BL/6

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Gulotm1Mae/Gulotm1Mae
Genetic Background: involves: C57BL/6

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gulotm1Mae/Gulotm1Mae
Genetic Background: involves: C57BL/6

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gulotm1Mae/Gulotm1Mae
Genetic Background: involves: C57BL/6

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

Allelic Composition: Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tgfb3tm1Moaz/Tgfb3tm1.1Moaz,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

Allelic Composition: Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1)

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

Allelic Composition: Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1)

Allelic Composition: Tgfb3tm1Moaz/Tgfb3tm1.1Moaz,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mamstrtm1.1Eno/Mamstrtm1.1Eno,Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic Background: involves: 129 * C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0002239 abnormal nasal septum morphology "any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0002726 abnormal pulmonary vein morphology "structrual anomaly of the veins that return oxygenated blood from the lungs to the left atrium of the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0003092 reduced corneal stroma thickness "reduced width of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1)

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0005243 hemothorax "bleeding into the pleural space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0005299 abnormal eye posterior chamber "anomaly of the ringlike space, filled with aqueous humor, between the iris/pupil anteriorly and the lens and ciliary body posteriorly" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006072 abnormal retinal apoptosis "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008884 abnormal enterocyte apoptosis "change in the timing or the number of enterocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

Allelic Composition: Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1)

 MP:0009874 abnormal interdigital cell death "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009889 persistence of medial edge epithelium during palatal shelf fusion "palatal shelves meet at the midline during development but do not adhere along the medial edge epithelia, and fail to form the midline epithelial seam" [PMID:16680722]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

Allelic Composition: Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1)

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0010811 decreased type II pneumocyte number "reduced number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0010900 abnormal pulmonary interalveolar septum morphology "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

Allelic Composition: Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CF-1)

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

Allelic Composition: Tgfb3tm1Moaz/Tgfb3tm1.1Moaz,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tardbptm1b(EUCOMM)Wtsi/Tardbptm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tardbptm1b(EUCOMM)Wtsi/H

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0030006 decreased retinal apoptosis "decrease in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Tgfb2tm1Doe/Tgfb2tm1Doe,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001870 Ltbp1 / Q8CG19 / Latent-transforming growth factor beta-binding protein 1 / Q14766*  / complex / reaction
 ENSMUSG00000021253 Tgfb3 / transforming growth factor, beta 3 / P10600*  / complex
 ENSMUSG00000024940 Ltbp3 / latent transforming growth factor beta binding protein 3 / Q9NS15*  / reaction / complex






 

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