Manteia

ENSMUSG00000109523

Mus musculus

Features

Gene ID:	ENSMUSG00000109523

Biological name :	Gdf1

Synonyms :	Embryonic growth/differentiation factor 1 / Gdf1 / P20863

Possible biological names infered from orthology :	ceramide synthase 1 / CERS1 / growth differentiation factor 1 / P27539 / P27544

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	B3.3
Gene start:	70329817
Gene end:	70331587

Corresponding Affymetrix probe sets:	10572368 (MoGene1.0st) 1416900_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000146749 NCBI entrez gene - 14559 See in Manteia. MGI - MGI:95683 RefSeq - NM_008107 RefSeq Peptide - NP_032133 swissprot - P20863 Ensembl - ENSMUSG00000109523

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gdf3	ENSDARG00000037995	Danio rerio
GDF3	ENSGALG00000003161	Gallus gallus
CERS1	ENSG00000223802	Homo sapiens
GDF1	ENSG00000130283	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*	ENSMUSG00000087408	100
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*	ENSMUSG00000030117	34
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*	ENSMUSG00000021943	23
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*	ENSMUSG00000037171	20
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*	ENSMUSG00000025405	20
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*	ENSMUSG00000037035	19
Tgfb3 / transforming growth factor, beta 3 / P10600*	ENSMUSG00000021253	19
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*	ENSMUSG00000047492	19
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*	ENSMUSG00000038508	18
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*	ENSMUSG00000023279	18
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*	ENSMUSG00000002603	18
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*	ENSMUSG00000029335	18
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*	ENSMUSG00000041324	18
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*	ENSMUSG00000025352	17
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*	ENSMUSG00000039239	17
Mstn / O08689 / myostatin / O14793*	ENSMUSG00000026100	16
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*	ENSMUSG00000018238	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR001839	Transforming growth factor-beta, C-terminal
IPR015615	Transforming growth factor-beta-related
IPR017948	Transforming growth factor beta, conserved site
IPR029034	Cystine-knot cytokine

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0007165	signal transduction	IMP
biological_process	GO:0007492	endoderm development	IGI
biological_process	GO:0007498	mesoderm development	IGI
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA
biological_process	GO:0030509	BMP signaling pathway	IBA
biological_process	GO:0042981	regulation of apoptotic process	IBA
biological_process	GO:0043408	regulation of MAPK cascade	IBA
biological_process	GO:0048468	cell development	IBA
biological_process	GO:0060395	SMAD protein signal transduction	IBA
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005615	extracellular space	IEA
molecular_function	GO:0005125	cytokine activity	IEA
molecular_function	GO:0005160	transforming growth factor beta receptor binding	IBA
molecular_function	GO:0008083	growth factor activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000087	absent mandible	"missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000462	abnormal digestive system morphology	"anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ntrk2^tm2Kln/Ntrk2^tm2Kln,Tg(Camk2a-cre)159Kln/? Genetic Background: involves: 129S2/SvPas * CBA/J
MP:0000474	abnormal foregut morphology	"malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0000531	right pulmonary isomerism	"bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0000644	dextrocardia	"cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Acvr1c^tm1Cfi/Acvr1c⁺,Gdf1^tm1Sjl/Gdf1⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129 * C57BL/6
MP:0000826	abnormal third ventricle morphology	"malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000830	abnormal diencephalon morphology	"any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000932	absent notochord	"missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001683	absent mesoderm	"missing or failure to differentiate the middle primary germ layer " [J:40594]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gdf1^tm1Sjl/Gdf1⁺,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001706	abnormal left-right axis patterning	"anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Gdf1^tm1Sjl/Gdf1⁺,Gdf3^{Gt(AD0857)Wtsi}/Gdf3⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Gdf3^{Gt(AD0857)Wtsi}/Gdf3⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002230	abnormal primitive streak formation	"anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Acvr1c^tm1Cfi/Acvr1c⁺,Gdf1^tm1Sjl/Gdf1⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gdf1^tm1Sjl/Gdf1⁺,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002239	abnormal nasal septum morphology	"any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Acvr1c^tm1Cfi/Acvr1c⁺,Gdf1^tm1Sjl/Gdf1⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129 * C57BL/6
MP:0002766	situs inversus	"lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0004110	transposition of great arteries	"cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0004133	heterotaxia	"abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ntrk2^tm2Kln/Ntrk2^tm2Kln,Tg(Camk2a-cre)159Kln/? Genetic Background: involves: 129S2/SvPas * CBA/J
MP:0004388	absent prechordal plate	"absence of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004714	truncated notochord	"notochord morphology that terminates abruptly as if having an end or point cut off" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004837	abnormal neural fold formation	"any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005157	holoprosencephaly	"presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Acvr1b^tm1Enl/Acvr1b⁺,Gdf1^tm1Sjl/Gdf1^tm1Sjl Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0005170	cleft lip	"defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005657	abnormal neural plate morphology	"malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006062	abnormal vena cava morphology	"structural malformation of either of the two largest veins in the body " [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0006261	annular pancreas	"an abnormal ring or collar of pancreatic tissue that encircles the duodenum" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:69854]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0006337	abnormal first branchial arch morphology	"anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gdf1^tm1Sjl/Gdf1⁺,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009266	abnormal mesendoderm development	"failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009905	absent tongue	"absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0010335	fused first branchial arch	"the first arch fails to fully divide along the midline" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0010413	complete atrioventricular septal defect	"a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Ntrk2^tm2Kln/Ntrk2^tm2Kln,Tg(Camk2a-cre)159Kln/? Genetic Background: involves: 129S2/SvPas * CBA/J
MP:0011106	partial embryonic lethality before somite formation	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gdf1^tm1Sjl/Gdf1⁺,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0011255	abnormal anterior visceral endoderm cell migration	"any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1⁺,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0012157	rostral body truncation	"rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]	Show Allelic Composition: Acvr1b^tm1Enl/Acvr1b⁺,Gdf1^tm1Sjl/Gdf1^tm1Sjl Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0012159	absent anterior visceral endoderm	"absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:anna]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gdf1^tm1Sjl/Gdf1⁺,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0012685	abnormal primitive streak elongation	"any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gdf1^tm1Sjl/Gdf1⁺,Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0030198	nasal septum hypoplasia	"underdevelopment or reduced size of the nasal septum, usually due to a reduced number of cells" [MGI:anna]	Show Allelic Composition: Gdf1^tm1Sjl/Gdf1^tm1Sjl,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000532	Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*	/ reaction / complex
ENSMUSG00000026124	Cfc1 / P97766 / Cryptic protein / CFC1B* / P0CG36* / P0CG37* / cripto, FRL-1, cryptic family 1* / cripto, FRL-1, cryptic family 1B*	/ reaction / complex
ENSMUSG00000026834	Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*	/ reaction / complex
ENSMUSG00000061393	Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*	/ complex / reaction
ENSMUSG00000052155	Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*	/ complex / reaction
ENSMUSG00000037171	Nodal / P43021 / Q96S42* / nodal growth differentiation factor*	/ complex

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