ENSMUSG00000023279


Mus musculus

Features
Gene ID: ENSMUSG00000023279
  
Biological name :Bmp15
  
Synonyms : Bmp15 / Bone morphotic protein 15 / Q9Z0L4
  
Possible biological names infered from orthology : bone morphogenetic protein 15 / O95972
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.1
Gene start: 6314107
Gene end: 6320721
  
Corresponding Affymetrix probe sets: 10603270 (MoGene1.0st)   1420005_s_at (Mouse Genome 430 2.0 Array)   1420006_at (Mouse Genome 430 2.0 Array)   1450210_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024049
NCBI entrez gene - 12155     See in Manteia.
MGI - MGI:1316745
RefSeq - NM_009757
RefSeq Peptide - NP_033887
swissprot - Q9Z0L4
Ensembl - ENSMUSG00000023279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BMP15ENSG00000130385Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823829
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194319
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132417
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717117
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749216
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610016
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952316
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011716
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740816
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125315
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923915
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260315
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535215
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933515
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703514
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850813
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540512


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR015923  Bone morphogenetic protein 15
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060016 granulosa cell development IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003696 abnormal zona pellucida "anomaly or absence of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009374 failure of cumulus expansion "complete inability of the cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009433 polyovular ovarian follicle "an ovarian follicle containing more than one oocyte (ovum)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp15tm1Zuk/Bmp15tm1Zuk,Gdf9tm1Zuk/Gdf9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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