ENSMUSG00000029335


Mus musculus

Features
Gene ID: ENSMUSG00000029335
  
Biological name :Bmp3
  
Synonyms : Bmp3 / Bone morphotic protein 3 / Q8BHE5
  
Possible biological names infered from orthology : bone morphogenetic protein 3 / P12645
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E3
Gene start: 98854415
Gene end: 98884396
  
Corresponding Affymetrix probe sets: 10523506 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000142662
Ensembl peptide - ENSMUSP00000142907
Ensembl peptide - ENSMUSP00000031278
NCBI entrez gene - 110075     See in Manteia.
MGI - MGI:88179
RefSeq - NM_001310677
RefSeq - NM_173404
RefSeq Peptide - NP_001297606
RefSeq Peptide - NP_775580
swissprot - Q8BHE5
swissprot - A0A0G2JE75
swissprot - Q149J9
swissprot - A0A0G2JEU2
Ensembl - ENSMUSG00000029335
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp3ENSDARG00000060526Danio rerio
 BMP3ENSGALG00000035052Gallus gallus
 BMP3ENSG00000152785Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194335
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952314
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740814
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717113
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011713
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327913
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823813
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850811
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703511
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125311
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260311
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923910
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132410
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749210
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535210
Mstn / O08689 / myostatin / O14793*ENSMUSG000000261009
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG000000254059


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017197  Bone morphogenetic protein 3/3B
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0070700 BMP receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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