ENSMUSG00000030117


Mus musculus

Features
Gene ID: ENSMUSG00000030117
  
Biological name :Gdf3
  
Synonyms : Gdf3 / Growth/differentiation factor 3 / Q07104
  
Possible biological names infered from orthology : Q9NR23
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 122605403
Gene end: 122610087
  
Corresponding Affymetrix probe sets: 10547633 (MoGene1.0st)   1449288_at (Mouse Genome 430 2.0 Array)   1460057_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032211
NCBI entrez gene - 14562     See in Manteia.
MGI - MGI:95686
RefSeq - NM_008108
RefSeq Peptide - NP_032134
swissprot - Q07104
Ensembl - ENSMUSG00000030117
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf3ENSDARG00000037995Danio rerio
 GDF3ENSGALG00000003161Gallus gallus
 GDF3ENSG00000184344Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740834
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952334
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194322
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610021
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132421
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717121
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703520
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125319
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749219
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260318
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923918
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850818
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540518
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535218
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933517
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327917
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823817


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001654 eye development IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0002021 response to dietary excess IMP
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0010453 regulation of cell fate commitment IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0032525 somite rostral/caudal axis specification IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0045605 negative regulation of epidermal cell differentiation IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048859 formation of anatomical boundary IMP
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0090009 primitive streak formation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1+,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

 MP:0001687 thin endoderm "reduced thickness of the innermost germ layer of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf1tm1Sjl/Gdf1+,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Gdf3Gt(AD0857)Wtsi/Gdf3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

Allelic Composition: Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1+,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004713 split notochord "the appearance of an abnormal division in the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Vac14Gt(RRP155)Byg/Vac14ingls
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0008533 abnormal anterior visceral endoderm "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1+,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gdf3tm1Zuk/Gdf3tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Gdf3tm1Zuk/Gdf3tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Gdf3tm1Zuk/Gdf3tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gdf3tm1Zuk/Gdf3tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1+,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011255 abnormal anterior visceral endoderm cell migration "any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

Allelic Composition: Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1+,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

 MP:0012156 rostral-caudal axis duplication "partial or complete duplication of rostral-caudal axis structures" [MGI:anna]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
Show

Allelic Composition: Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012159 absent anterior visceral endoderm "absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:anna]
Show

Allelic Composition: Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1+,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
Show

Allelic Composition: Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1tm1Sjl,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gdf1tm1Sjl/Gdf1+,Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013207 absent endoderm "absence of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) that is formed during gastrulation" [MGI:anna]
Show

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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