ENSMUSG00000021943


Mus musculus

Features
Gene ID: ENSMUSG00000021943
  
Biological name :Gdf10
  
Synonyms : Gdf10 / Growth/differentiation factor 10 / P97737
  
Possible biological names infered from orthology : P55107
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 33923587
Gene end: 33937983
  
Corresponding Affymetrix probe sets: 10414025 (MoGene1.0st)   1424007_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128621
NCBI entrez gene - 14560     See in Manteia.
MGI - MGI:95684
RefSeq - NM_145741
RefSeq Peptide - NP_665684
swissprot - P97737
Ensembl - ENSMUSG00000021943
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf10aENSDARG00000095378Danio rerio
 gdf10bENSDARG00000073891Danio rerio
 GDF10ENSGALG00000005985Gallus gallus
 GDF10ENSG00000266524Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933534
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952317
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740817
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011717
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327916
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717116
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823815
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132414
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703514
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125314
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749214
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923914
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535213
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540513
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850813
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610012
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017197  Bone morphogenetic protein 3/3B
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation IDA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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