ENSG00000266524


Homo sapiens

Features
Gene ID: ENSG00000266524
  
Biological name :GDF10
  
Synonyms : GDF10 / growth differentiation factor 10 / P55107
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q11.22
Gene start: 47300386
Gene end: 47313547
  
Corresponding Affymetrix probe sets: 206159_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464145
NCBI entrez gene - 2662     See in Manteia.
OMIM - 601361
RefSeq - NM_004962
RefSeq Peptide - NP_004953
swissprot - P55107
Ensembl - ENSG00000266524
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf10aENSDARG00000095378Danio rerio
 gdf10bENSDARG00000073891Danio rerio
 GDF10ENSGALG00000005985Gallus gallus
 Gdf10ENSMUSG00000021943Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMP3 / P12645 / bone morphogenetic protein 3ENSG0000015278544
CERS1 / P27544 / ceramide synthase 1ENSG0000022380220
GDF1 / P27539 / growth differentiation factor 1ENSG0000013028320
GDF3 / Q9NR23 / growth differentiation factor 3ENSG0000018434418
NODAL / Q96S42 / nodal growth differentiation factorENSG0000015657416
GDF9 / O60383 / growth differentiation factor 9ENSG0000016440415
BMP15 / O95972 / bone morphogenetic protein 15ENSG0000013038514
TGFB2 / P61812 / transforming growth factor beta 2ENSG0000009296914
INHBC / P55103 / inhibin beta C subunitENSG0000017518914
INHBE / P58166 / inhibin beta E subunitENSG0000013926914
INHBA / P08476 / inhibin beta A subunitENSG0000012264114
GDF15 / Q99988 / growth differentiation factor 15ENSG0000013051313
GDF11 / O95390 / growth differentiation factor 11ENSG0000013541413
TGFB3 / P10600 / transforming growth factor beta 3ENSG0000011969913
MSTN / O14793 / myostatinENSG0000013837913
TGFB1 / P01137 / transforming growth factor beta 1ENSG0000010532912
INHBB / P09529 / inhibin beta B subunitENSG0000016308312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017197  Bone morphogenetic protein 3/3B
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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