ENSG00000139269


Homo sapiens

Features
Gene ID: ENSG00000139269
  
Biological name :INHBE
  
Synonyms : INHBE / inhibin beta E subunit / P58166
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.3
Gene start: 57452323
Gene end: 57459280
  
Corresponding Affymetrix probe sets: 210587_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000266646
Ensembl peptide - ENSP00000450212
NCBI entrez gene - 83729     See in Manteia.
OMIM - 612031
RefSeq - NM_031479
RefSeq Peptide - NP_113667
swissprot - P58166
swissprot - F8VNP4
Ensembl - ENSG00000139269
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INHBEENSDARG00000100986Danio rerio
 InhbeENSMUSG00000047492Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INHBC / P55103 / inhibin beta C subunitENSG0000017518941
INHBA / P08476 / inhibin beta A subunitENSG0000012264133
INHBB / P09529 / inhibin beta B subunitENSG0000016308332
TGFB1 / P01137 / transforming growth factor beta 1ENSG0000010532925
GDF11 / O95390 / growth differentiation factor 11ENSG0000013541424
TGFB3 / P10600 / transforming growth factor beta 3ENSG0000011969923
MSTN / O14793 / myostatinENSG0000013837922
NODAL / Q96S42 / nodal growth differentiation factorENSG0000015657422
TGFB2 / P61812 / transforming growth factor beta 2ENSG0000009296922
CERS1 / P27544 / ceramide synthase 1ENSG0000022380221
GDF3 / Q9NR23 / growth differentiation factor 3ENSG0000018434421
GDF1 / P27539 / growth differentiation factor 1ENSG0000013028321
BMP3 / P12645 / bone morphogenetic protein 3ENSG0000015278519
GDF10 / P55107 / growth differentiation factor 10ENSG0000026652419
GDF9 / O60383 / growth differentiation factor 9ENSG0000016440416
BMP15 / O95972 / bone morphogenetic protein 15ENSG0000013038516
GDF15 / Q99988 / growth differentiation factor 15ENSG0000013051315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001318  Inhibin, beta C subunit
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Glycoprotein hormones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123999 INHA / P05111 / inhibin alpha subunit  / complex
 ENSG00000139269 INHBE / P58166 / inhibin beta E subunit  / complex
 ENSG00000122641 INHBA / P08476 / inhibin beta A subunit  / complex
 ENSG00000175189 INHBC / P55103 / inhibin beta C subunit  / complex
 ENSG00000163083 INHBB / P09529 / inhibin beta B subunit  / complex






 

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