ENSG00000163083


Homo sapiens

Features
Gene ID: ENSG00000163083
  
Biological name :INHBB
  
Synonyms : INHBB / inhibin beta B subunit / P09529
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q14.2
Gene start: 120346143
Gene end: 120351808
  
Corresponding Affymetrix probe sets: 205258_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295228
NCBI entrez gene - 3625     See in Manteia.
OMIM - 147390
RefSeq - NM_002193
RefSeq Peptide - NP_002184
swissprot - P09529
Ensembl - ENSG00000163083
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01074203.1ENSDARG00000103892Danio rerio
 inhbbENSDARG00000040777Danio rerio
 INHBBENSGALG00000028770Gallus gallus
 InhbbENSMUSG00000037035Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INHBA / P08476 / inhibin beta A subunitENSG0000012264142
INHBC / P55103 / inhibin beta C subunitENSG0000017518933
INHBE / P58166 / inhibin beta E subunitENSG0000013926928
GDF11 / O95390 / growth differentiation factor 11ENSG0000013541420
MSTN / O14793 / myostatinENSG0000013837919
GDF3 / Q9NR23 / growth differentiation factor 3ENSG0000018434418
TGFB2 / P61812 / transforming growth factor beta 2ENSG0000009296918
TGFB1 / P01137 / transforming growth factor beta 1ENSG0000010532918
TGFB3 / P10600 / transforming growth factor beta 3ENSG0000011969918
GDF1 / P27539 / growth differentiation factor 1ENSG0000013028317
NODAL / Q96S42 / nodal growth differentiation factorENSG0000015657417
CERS1 / P27544 / ceramide synthase 1ENSG0000022380217
BMP15 / O95972 / bone morphogenetic protein 15ENSG0000013038515
BMP3 / P12645 / bone morphogenetic protein 3ENSG0000015278515
GDF9 / O60383 / growth differentiation factor 9ENSG0000016440414
GDF10 / P55107 / growth differentiation factor 10ENSG0000026652414
GDF15 / Q99988 / growth differentiation factor 15ENSG0000013051310


Protein motifs (from Interpro)
Interpro ID Name
 IPR000381  Inhibin, beta B subunit
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development NAS
 biological_processGO:0006952 defense response TAS
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009611 response to wounding IEP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030154 cell differentiation NAS
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032924 activin receptor signaling pathway IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0044320 cellular response to leptin stimulus IEA
 biological_processGO:0044650 adhesion of symbiont to host cell IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046881 positive regulation of follicle-stimulating hormone secretion IPI
 biological_processGO:0046882 negative regulation of follicle-stimulating hormone secretion IPI
 biological_processGO:0048178 negative regulation of hepatocyte growth factor biosynthetic process IDA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048599 oocyte development IEA
 biological_processGO:0060279 positive regulation of ovulation IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005179 hormone activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046789 host cell surface receptor binding TAS


Pathways (from Reactome)
Pathway description
Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121989 ACVR2A / P27037 / activin A receptor type 2A  / complex / reaction
 ENSG00000123999 INHA / P05111 / inhibin alpha subunit  / complex
 ENSG00000123612 ACVR1C / Q8NER5 / activin A receptor type 1C  / complex / reaction
 ENSG00000135503 ACVR1B / P36896 / activin A receptor type 1B  / complex / reaction
 ENSG00000163083 INHBB / P09529 / inhibin beta B subunit  / complex
 ENSG00000139269 INHBE / P58166 / inhibin beta E subunit  / complex
 ENSG00000175189 INHBC / P55103 / inhibin beta C subunit  / complex
 ENSG00000070404 FSTL3 / O95633 / follistatin like 3  / reaction / complex
 ENSG00000134363 FST / P19883 / follistatin  / reaction / complex
 ENSG00000114739 ACVR2B / Q13705 / activin A receptor type 2B  / complex / reaction
 ENSG00000122641 INHBA / P08476 / inhibin beta A subunit  / complex






 

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