ENSG00000134363


Homo sapiens

Features
Gene ID: ENSG00000134363
  
Biological name :FST
  
Synonyms : follistatin / FST / P19883
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q11.2
Gene start: 53480409
Gene end: 53487134
  
Corresponding Affymetrix probe sets: 204948_s_at (Human Genome U133 Plus 2.0 Array)   207345_at (Human Genome U133 Plus 2.0 Array)   226847_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426971
Ensembl peptide - ENSP00000256759
Ensembl peptide - ENSP00000380151
Ensembl peptide - ENSP00000426315
NCBI entrez gene - 10468     See in Manteia.
OMIM - 136470
RefSeq - XM_017008955
RefSeq - XM_005248400
RefSeq - XM_005248401
RefSeq - XM_005248402
RefSeq - XM_005248403
RefSeq - XM_011543099
RefSeq - XM_017008954
RefSeq - NM_006350
RefSeq - NM_013409
RefSeq Peptide - NP_006341
RefSeq Peptide - NP_037541
swissprot - H0YA75
swissprot - H0YAF9
swissprot - P19883
swissprot - A0A024QZU6
Ensembl - ENSG00000134363
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fstaENSDARG00000052846Danio rerio
 fstbENSDARG00000057992Danio rerio
 FSTENSGALG00000014908Gallus gallus
 FstENSMUSG00000021765Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FSTL3 / O95633 / follistatin like 3ENSG0000007040432


Protein motifs (from Interpro)
Interpro ID Name
 IPR002350  Kazal domain
 IPR003645  Follistatin-like, N-terminal
 IPR015369  Follistatin/Osteonectin EGF domain
 IPR017878  TB domain
 IPR036058  Kazal domain superfamily
 IPR036773  TGF-beta binding (TB) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0032926 negative regulation of activin receptor signaling pathway IDA
 biological_processGO:0051798 positive regulation of hair follicle development IDA
 cellular_componentGO:0005576 extracellular region TAS
 molecular_functionGO:0004871 obsolete signal transducer activity NAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA
 molecular_functionGO:0048185 activin binding IPI


Pathways (from Reactome)
Pathway description
Antagonism of Activin by Follistatin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122641 INHBA / P08476 / inhibin beta A subunit  / reaction / complex
 ENSG00000134363 FST / P19883 / follistatin  / reaction / complex
 ENSG00000163083 INHBB / P09529 / inhibin beta B subunit  / complex / reaction






 

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