ENSG00000122641


Homo sapiens

Features
Gene ID: ENSG00000122641
  
Biological name :INHBA
  
Synonyms : INHBA / inhibin beta A subunit / P08476
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p14.1
Gene start: 41667168
Gene end: 41705834
  
Corresponding Affymetrix probe sets: 204926_at (Human Genome U133 Plus 2.0 Array)   210511_s_at (Human Genome U133 Plus 2.0 Array)   227140_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397197
Ensembl peptide - ENSP00000490646
Ensembl peptide - ENSP00000242208
NCBI entrez gene - 3624     See in Manteia.
OMIM - 147290
RefSeq - NM_002192
RefSeq - XM_017012176
RefSeq Peptide - NP_002183
swissprot - A4D1W7
swissprot - P08476
Ensembl - ENSG00000122641
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inhbaaENSDARG00000012671Danio rerio
 inhbabENSDARG00000024759Danio rerio
 INHBAENSGALG00000034616Gallus gallus
 InhbaENSMUSG00000041324Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INHBB / P09529 / inhibin beta B subunitENSG0000016308340
INHBC / P55103 / inhibin beta C subunitENSG0000017518930
INHBE / P58166 / inhibin beta E subunitENSG0000013926927
GDF11 / O95390 / growth differentiation factor 11ENSG0000013541422
TGFB3 / P10600 / transforming growth factor beta 3ENSG0000011969921
TGFB2 / P61812 / transforming growth factor beta 2ENSG0000009296920
MSTN / O14793 / myostatinENSG0000013837920
TGFB1 / P01137 / transforming growth factor beta 1ENSG0000010532920
NODAL / Q96S42 / nodal growth differentiation factorENSG0000015657418
GDF3 / Q9NR23 / growth differentiation factor 3ENSG0000018434418
GDF1 / P27539 / growth differentiation factor 1ENSG0000013028317
CERS1 / P27544 / ceramide synthase 1ENSG0000022380217
BMP15 / O95972 / bone morphogenetic protein 15ENSG0000013038516
BMP3 / P12645 / bone morphogenetic protein 3ENSG0000015278516
GDF10 / P55107 / growth differentiation factor 10ENSG0000026652415
GDF9 / O60383 / growth differentiation factor 9ENSG0000016440415
GDF15 / Q99988 / growth differentiation factor 15ENSG0000013051312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000491  Inhibin, beta A subunit
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IDA
 biological_processGO:0001541 ovarian follicle development NAS
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001942 hair follicle development IGI
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006952 defense response TAS
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007399 nervous system development NAS
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008584 male gonad development IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0021773 striatal medium spiny neuron differentiation IDA
 biological_processGO:0030154 cell differentiation TAS
 biological_processGO:0030218 erythrocyte differentiation NAS
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IDA
 biological_processGO:0032924 activin receptor signaling pathway IDA
 biological_processGO:0035987 endodermal cell differentiation IDA
 biological_processGO:0042326 negative regulation of phosphorylation TAS
 biological_processGO:0042476 odontogenesis IGI
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0042541 hemoglobin biosynthetic process IDA
 biological_processGO:0042701 progesterone secretion IGI
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045077 negative regulation of interferon-gamma biosynthetic process TAS
 biological_processGO:0045578 negative regulation of B cell differentiation TAS
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IDA
 biological_processGO:0045650 negative regulation of macrophage differentiation TAS
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046880 regulation of follicle-stimulating hormone secretion IGI
 biological_processGO:0046881 positive regulation of follicle-stimulating hormone secretion TAS
 biological_processGO:0046882 negative regulation of follicle-stimulating hormone secretion NAS
 biological_processGO:0048333 mesodermal cell differentiation IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0051799 negative regulation of hair follicle development IDA
 biological_processGO:0060021 roof of mouth development IGI
 biological_processGO:0060279 positive regulation of ovulation ISS
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0061029 eyelid development in camera-type eye ISS
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:0097154 GABAergic neuron differentiation IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0043509 activin A complex IDA
 cellular_componentGO:0043512 inhibin A complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005179 hormone activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0017046 peptide hormone binding IPI
 molecular_functionGO:0034711 inhibin binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070699 type II activin receptor binding IPI


Pathways (from Reactome)
Pathway description
Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121989 ACVR2A / P27037 / activin A receptor type 2A  / reaction / complex
 ENSG00000123612 ACVR1C / Q8NER5 / activin A receptor type 1C  / complex / reaction
 ENSG00000122641 INHBA / P08476 / inhibin beta A subunit  / complex
 ENSG00000134363 FST / P19883 / follistatin  / reaction / complex
 ENSG00000070404 FSTL3 / O95633 / follistatin like 3  / reaction / complex
 ENSG00000114739 ACVR2B / Q13705 / activin A receptor type 2B  / complex / reaction
 ENSG00000135503 ACVR1B / P36896 / activin A receptor type 1B  / complex / reaction
 ENSG00000175189 INHBC / P55103 / inhibin beta C subunit  / complex
 ENSG00000123999 INHA / P05111 / inhibin alpha subunit  / complex
 ENSG00000139269 INHBE / P58166 / inhibin beta E subunit  / complex
 ENSG00000163083 INHBB / P09529 / inhibin beta B subunit  / complex






 

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