ENSG00000070404


Homo sapiens

Features
Gene ID: ENSG00000070404
  
Biological name :FSTL3
  
Synonyms : follistatin like 3 / FSTL3 / O95633
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 676365
Gene end: 683399
  
Corresponding Affymetrix probe sets: 203592_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466383
Ensembl peptide - ENSP00000484412
Ensembl peptide - ENSP00000484376
Ensembl peptide - ENSP00000483064
Ensembl peptide - ENSP00000477770
Ensembl peptide - ENSP00000166139
NCBI entrez gene - 10272     See in Manteia.
OMIM - 605343
RefSeq - NM_005860
RefSeq Peptide - NP_005851
swissprot - K7EM71
swissprot - A0A087X1Q2
swissprot - O95633
swissprot - A0A087WTD3
swissprot - A0A024R1Y8
Ensembl - ENSG00000070404
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fstl3ENSDARG00000025670Danio rerio
 FSTL3ENSGALG00000042356Gallus gallus
 Fstl3ENSMUSG00000020325Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FST / P19883 / follistatinENSG0000013436341


Protein motifs (from Interpro)
Interpro ID Name
 IPR002350  Kazal domain
 IPR003645  Follistatin-like, N-terminal
 IPR015369  Follistatin/Osteonectin EGF domain
 IPR017878  TB domain
 IPR036058  Kazal domain superfamily
 IPR036773  TGF-beta binding (TB) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0022409 positive regulation of cell-cell adhesion IDA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030325 adrenal gland development IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IDA
 biological_processGO:0032926 negative regulation of activin receptor signaling pathway IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045671 negative regulation of osteoclast differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0071248 cellular response to metal ion IEA
 biological_processGO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0044306 neuron projection terminus IEA
 molecular_functionGO:0001968 fibronectin binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0048185 activin binding IPI


Pathways (from Reactome)
Pathway description
Antagonism of Activin by Follistatin
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070404 FSTL3 / O95633 / follistatin like 3  / complex / reaction
 ENSG00000122641 INHBA / P08476 / inhibin beta A subunit  / complex / reaction
 ENSG00000163083 INHBB / P09529 / inhibin beta B subunit  / reaction / complex






 

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