ENSMUSG00000020325


Mus musculus

Features
Gene ID: ENSMUSG00000020325
  
Biological name :Fstl3
  
Synonyms : Follistatin-related protein 3 / Fstl3 / Q9EQC7
  
Possible biological names infered from orthology : follistatin like 3 / O95633
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79777272
Gene end: 79782630
  
Corresponding Affymetrix probe sets: 10364494 (MoGene1.0st)   1422803_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020575
NCBI entrez gene - 83554     See in Manteia.
MGI - MGI:1890391
RefSeq - NM_031380
RefSeq Peptide - NP_113557
swissprot - Q542M9
swissprot - Q9EQC7
Ensembl - ENSMUSG00000020325
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fstl3ENSDARG00000025670Danio rerio
 FSTL3ENSGALG00000042356Gallus gallus
 FSTL3ENSG00000070404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fst / follistatin FST315 / P19883* / follistatin*ENSMUSG0000002176542


Protein motifs (from Interpro)
Interpro ID Name
 IPR002350  Kazal domain
 IPR003645  Follistatin-like, N-terminal
 IPR015369  Follistatin/Osteonectin EGF domain
 IPR017878  TB domain
 IPR036058  Kazal domain superfamily
 IPR036773  TGF-beta binding (TB) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0022409 positive regulation of cell-cell adhesion IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030325 adrenal gland development IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0032926 negative regulation of activin receptor signaling pathway IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071248 cellular response to metal ion IEA
 biological_processGO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0044306 neuron projection terminus IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0048185 activin binding IEA


Pathways (from Reactome)
Pathway description
Antagonism of Activin by Follistatin
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
Show

Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003820 increased left ventricle systolic pressure "increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1.1Jro/Cdk2+
Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020325 Fstl3 / Q9EQC7 / Follistatin-related protein 3 / O95633* / follistatin like 3*  / complex / reaction
 ENSMUSG00000037035 Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*  / reaction / complex
 ENSMUSG00000041324 Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*  / complex / reaction






 

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