ENSMUSG00000037035


Mus musculus

Features
Gene ID: ENSMUSG00000037035
  
Biological name :Inhbb
  
Synonyms : Inhbb / Inhibin beta B chain / Q04999
  
Possible biological names infered from orthology : inhibin beta B subunit / P09529
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.3
Gene start: 119415465
Gene end: 119422248
  
Corresponding Affymetrix probe sets: 10357155 (MoGene1.0st)   1426858_at (Mouse Genome 430 2.0 Array)   1426859_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044918
NCBI entrez gene - 16324     See in Manteia.
MGI - MGI:96571
RefSeq - NM_008381
RefSeq Peptide - NP_032407
swissprot - Q04999
Ensembl - ENSMUSG00000037035
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01074203.1ENSDARG00000103892Danio rerio
 inhbbENSDARG00000040777Danio rerio
 INHBBENSGALG00000028770Gallus gallus
 INHBBENSG00000163083Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132442
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540530
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749227
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535220
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923919
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610019
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125319
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717118
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260318
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011718
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194316
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952316
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740816
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823813
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327913
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933512
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000381  Inhibin, beta B subunit
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development TAS
 biological_processGO:0009267 cellular response to starvation IEP
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009612 response to mechanical stimulus ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0032869 cellular response to insulin stimulus IEP
 biological_processGO:0032924 activin receptor signaling pathway IEA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0044320 cellular response to leptin stimulus IEP
 biological_processGO:0045444 fat cell differentiation IEP
 biological_processGO:0046676 negative regulation of insulin secretion IMP
 biological_processGO:0046881 positive regulation of follicle-stimulating hormone secretion IEA
 biological_processGO:0046882 negative regulation of follicle-stimulating hormone secretion IEA
 biological_processGO:0048178 negative regulation of hepatocyte growth factor biosynthetic process IEA
 biological_processGO:0048599 oocyte development IGI
 biological_processGO:0060279 positive regulation of ovulation IMP
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IGI
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000125 absent incisors "missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Inhbatm1Zuk/Inhbatm3Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
Show

Allelic Composition: Mycntm1Knd/Mycntm1Knd
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001313 increased incidence of corneal inflammation "greater than average and persistent occurrence of corneal irritation" [J:4606]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Inhbbtm1Grid/Inhbbtm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbe/Inhbctm1Sjl/Inhbe/Inhbctm1Sjl
Genetic Background: B6.129-Inhbe/Inhbctm1Sjl

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Inhbe/Inhbctm1Sjl/Inhbe/Inhbctm1Sjl
Genetic Background: B6.129-Inhbe/Inhbctm1Sjl

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Inhbatm1Zuk/Inhba+,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Inhbatm1Zuk/Inhba+,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002293 long gestation period "increase in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002681 increased number of corpora lutea "greater than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Inhbatm1Zuk/Inhba+,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003153 early eyelid opening "early average time for the first postnatal eye opening" [J:92240, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbbtm1Grid/Inhbbtm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003346 abnormal pectoral muscle morphology "anomaly in the two muscles that make up the upper and fore part of the chest that adduct and rotate the arm and lift the ribs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Fsttm1Zuk/Fst+,Mstntm1Sjl/Mstn+
Genetic Background: B6.129-Mstntm1Sjl Fsttm1Zuk

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0004855 increased ovary weight "greater average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0005131 increased follicle stimulating hormone level "greater than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Inhbbtm1Grid/Inhbbtm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0009505 abnormal mammary gland lobule morphology "any structural anomaly of a group of alveoli and the intralobular portion of the terminal duct of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0010238 increased skeletal muscle weight "greater than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fsttm1Zuk/Fst+,Mstntm1Sjl/Mstn+
Genetic Background: B6.129-Mstntm1Sjl Fsttm1Zuk

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0013718 galactostasis "abnormal accumulation of milk within the mammary gland alveoli and ducts due to failure of ejection (letdown) from the gland; may be associated with nipple anatomic abnormalities" [MGI:Anna]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026834 Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*  / reaction / complex
 ENSMUSG00000021765 Fst / follistatin FST315 / P19883* / follistatin*  / complex / reaction
 ENSMUSG00000020325 Fstl3 / Q9EQC7 / Follistatin-related protein 3 / O95633* / follistatin like 3*  / complex / reaction
 ENSMUSG00000025405 Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*  / complex
 ENSMUSG00000041324 Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*  / complex
 ENSMUSG00000037035 Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*  / complex
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / complex / reaction
 ENSMUSG00000032968 Inha / Q04997 / Inhibin alpha chain / P05111* / inhibin alpha subunit*  / complex
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / reaction / complex
 ENSMUSG00000000532 Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*  / complex / reaction
 ENSMUSG00000047492 Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*  / complex






 

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