ENSMUSG00000032968


Mus musculus

Features
Gene ID: ENSMUSG00000032968
  
Biological name :Inha
  
Synonyms : Inha / Inhibin alpha chain / Q04997
  
Possible biological names infered from orthology : inhibin alpha subunit / P05111
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C4
Gene start: 75507077
Gene end: 75510366
  
Corresponding Affymetrix probe sets: 10347669 (MoGene1.0st)   1422728_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040310
NCBI entrez gene - 16322     See in Manteia.
MGI - MGI:96569
RefSeq - NM_010564
RefSeq Peptide - NP_034694
swissprot - Q04997
Ensembl - ENSMUSG00000032968
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inhaENSDARG00000052433Danio rerio
 INHAENSGALG00000011234Gallus gallus
 P43031ENSGALG00000029515Gallus gallus
 INHAENSG00000123999Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017175  Inhibin, alpha subunit
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042541 hemoglobin biosynthetic process IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0046882 negative regulation of follicle-stimulating hormone secretion IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0034673 inhibin-betaglycan-ActRII complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043512 inhibin A complex IEA
 cellular_componentGO:0043513 inhibin B complex IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0034711 inhibin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Glycoprotein hormones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001123 dilated uterus "stretched or enlarged female muscular organ of gestation" [J:50844]
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Allelic Composition: Amhr2tm1Bhr/Amhr2tm1Bhr,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inha+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001148 enlarged testes "increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001939 secondary sex reversal "secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm1Bhr/Amhr2tm1Bhr,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Amhr2tm1Bhr/Amhr2tm1Bhr,Inhatm1Bay/Inha+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Amhr2tm1Bhr/Amhr2tm1Bhr,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002031 adrenal tumor "tumors of the adrenal gland, including phaeochomocytomas" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Inhatm1Bay/Inhatm1Bay,Smad3tm1Par/Smad3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBr * 129X1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adamts20bt-Bei1/Adamts20bt-Bei1,Adamts9tm1Dgen/Adamts9+
Genetic Background: B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Inhatm1Bay/Inhatm1Bay,Smad3tm1Par/Smad3tm1Par
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBr * 129X1/Sv * C57BL/6

 MP:0002789 male pseudohermaphroditism "pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm1Bhr/Amhr2tm1Bhr,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Amhr2tm1Bhr/Amhr2tm1Bhr,Inhatm1Bay/Inha+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004834 ovary hemorrhage "presence of bleeding in the ovary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0004855 increased ovary weight "greater average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005151 diffuse hepatic necrosis "disseminated pathologic death of cells within the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Amhr2tm1Bhr/Amhr2tm1Bhr,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Amhr2tm1Bhr/Amhr2tm1Bhr,Inhatm1Bay/Inha+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Inhatm1Bay/Inhatm1Bay,Smad3tm1Par/Smad3tm1Par
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBr * 129X1/Sv * C57BL/6

Allelic Composition: Inhatm1Bay/Inhatm1Bay,Smad3tm1Par/Smad3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBr * 129X1/Sv * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inha+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0009257 dilated seminiferous tubules "the luminal space of the seminiferous tubules is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0009590 gonad tumor "presence of abnormal rapidly proliferating cells in the testis or ovary, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0009592 Leydig cell tumor "rare testicular tumors of the male gonadal interstitium that are frequently hormonally active, leading to feminizing or virilizing syndromes; Leydig cell tumors comprise 1-3% of all testicular neoplasms, can be pure or mixed with other sex cord-stromal or germ cell tumors, and are usually benign, although malignant variants also occur" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm1Bhr/Amhr2tm1Bhr,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Amhr2tm1Bhr/Amhr2tm1Bhr,Inhatm1Bay/Inhatm1Bay
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025405 Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*  / complex
 ENSMUSG00000037035 Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*  / complex
 ENSMUSG00000041324 Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*  / complex
 ENSMUSG00000047492 Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*  / complex






 

1 s.

 
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