ENSG00000123999


Homo sapiens

Features
Gene ID: ENSG00000123999
  
Biological name :INHA
  
Synonyms : INHA / inhibin alpha subunit / P05111
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q35
Gene start: 219569162
Gene end: 219575713
  
Corresponding Affymetrix probe sets: 210141_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000243786
NCBI entrez gene - 3623     See in Manteia.
OMIM - 147380
RefSeq - NM_002191
RefSeq Peptide - NP_002182
swissprot - P05111
Ensembl - ENSG00000123999
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inhaENSDARG00000052433Danio rerio
 INHAENSGALG00000011234Gallus gallus
 P43031ENSGALG00000029515Gallus gallus
 InhaENSMUSG00000032968Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017175  Inhibin, alpha subunit
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030154 cell differentiation TAS
 biological_processGO:0030218 erythrocyte differentiation NAS
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042326 negative regulation of phosphorylation TAS
 biological_processGO:0042541 hemoglobin biosynthetic process IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045077 negative regulation of interferon-gamma biosynthetic process TAS
 biological_processGO:0045578 negative regulation of B cell differentiation TAS
 biological_processGO:0045650 negative regulation of macrophage differentiation TAS
 biological_processGO:0045786 negative regulation of cell cycle TAS
 biological_processGO:0046881 positive regulation of follicle-stimulating hormone secretion TAS
 biological_processGO:0046882 negative regulation of follicle-stimulating hormone secretion NAS
 biological_processGO:0048468 cell development IBA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0034673 inhibin-betaglycan-ActRII complex IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043512 inhibin A complex IDA
 cellular_componentGO:0043513 inhibin B complex IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005179 hormone activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0034711 inhibin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Glycoprotein hormones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163083 INHBB / P09529 / inhibin beta B subunit  / complex
 ENSG00000175189 INHBC / P55103 / inhibin beta C subunit  / complex
 ENSG00000139269 INHBE / P58166 / inhibin beta E subunit  / complex
 ENSG00000122641 INHBA / P08476 / inhibin beta A subunit  / complex






 

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