ENSMUSG00000041324


Mus musculus

Features
Gene ID: ENSMUSG00000041324
  
Biological name :Inhba
  
Synonyms : Inhba / Inhibin beta A chain / Q04998
  
Possible biological names infered from orthology : inhibin beta A subunit / P08476
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A1
Gene start: 16011851
Gene end: 16031621
  
Corresponding Affymetrix probe sets: 10403743 (MoGene1.0st)   1422053_at (Mouse Genome 430 2.0 Array)   1458291_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047894
Ensembl peptide - ENSMUSP00000132085
NCBI entrez gene - 16323     See in Manteia.
MGI - MGI:96570
RefSeq - XM_011244286
RefSeq - NM_008380
RefSeq - XM_006516558
RefSeq - XM_006516559
RefSeq - XM_011244285
RefSeq Peptide - NP_032406
swissprot - Q04998
swissprot - Q3UY39
Ensembl - ENSMUSG00000041324
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inhbaaENSDARG00000012671Danio rerio
 inhbabENSDARG00000024759Danio rerio
 INHBAENSGALG00000034616Gallus gallus
 INHBAENSG00000122641Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703541
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540530
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749227
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535222
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125321
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260321
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923921
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610020
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717119
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011718
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952316
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327916
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194316
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740816
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823815
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850812
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000491  Inhibin, beta A subunit
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle ISS
 biological_processGO:0001541 ovarian follicle development ISS
 biological_processGO:0001707 mesoderm formation IDA
 biological_processGO:0001942 hair follicle development ISS
 biological_processGO:0002244 hematopoietic progenitor cell differentiation ISO
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0007050 cell cycle arrest ISS
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0008584 male gonad development ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0021773 striatal medium spiny neuron differentiation ISO
 biological_processGO:0030308 negative regulation of cell growth ISS
 biological_processGO:0032270 positive regulation of cellular protein metabolic process ISO
 biological_processGO:0032924 activin receptor signaling pathway ISS
 biological_processGO:0035987 endodermal cell differentiation ISO
 biological_processGO:0042476 odontogenesis ISO
 biological_processGO:0042493 response to drug ISS
 biological_processGO:0042541 hemoglobin biosynthetic process ISS
 biological_processGO:0042701 progesterone secretion ISO
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation ISS
 biological_processGO:0045786 negative regulation of cell cycle ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046880 regulation of follicle-stimulating hormone secretion ISO
 biological_processGO:0048333 mesodermal cell differentiation IDA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0051799 negative regulation of hair follicle development ISO
 biological_processGO:0060021 roof of mouth development ISS
 biological_processGO:0060279 positive regulation of ovulation IMP
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0061029 eyelid development in camera-type eye IGI
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:0097154 GABAergic neuron differentiation ISO
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0043509 activin A complex ISO
 cellular_componentGO:0043512 inhibin A complex ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0017046 peptide hormone binding ISO
 molecular_functionGO:0034711 inhibin binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070699 type II activin receptor binding ISO


Pathways (from Reactome)
Pathway description
Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000125 absent incisors "missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]
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Allelic Composition: Mycntm1Knd/Mycntm1Knd
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000417 short hair "reduced average length of the hairs" [J:64948]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000424 retarded hair growth "slow growth of the hair, appears at normal time" [J:5476]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Fsttm1Zuk/Fst+,Mstntm1Sjl/Mstn+
Genetic Background: B6.129-Mstntm1Sjl Fsttm1Zuk

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Mycntm1Knd/Mycntm1Knd
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001435 no suckling reflex "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
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Allelic Composition: Mycntm1Knd/Mycntm1Knd
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Inhbatm1Zuk/Inhbatm3Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Inhbatm1Zuk/Inhba+,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Inhbatm1Zuk/Inhba+,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Inhbatm1Zuk/Inhba+,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0002681 increased number of corpora lutea "greater than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Inhbatm1Zuk/Inhbatm3Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Inhbatm1Zuk/Inhba+,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003346 abnormal pectoral muscle morphology "anomaly in the two muscles that make up the upper and fore part of the chest that adduct and rotate the arm and lift the ribs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fsttm1Zuk/Fst+,Mstntm1Sjl/Mstn+
Genetic Background: B6.129-Mstntm1Sjl Fsttm1Zuk

 MP:0003529 enlarged clitoris "increased size of the small, erectile body located at the anterior end of the vulva" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003599 large penis "enlarged size of the organ of copulation and urination in the male" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0004189 abnormal alveolar process "any structural anomaly of the thickened ridge of bone in the mandible and maxilla that holds the tooth sockets" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mycntm1Knd/Mycntm1Knd
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004791 absent lower incisors "missing the lower pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mycntm1Knd/Mycntm1Knd
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004855 increased ovary weight "greater average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0005131 increased follicle stimulating hormone level "greater than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006198 enophthalmos "sinking or retraction of the eye back into the socket" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008975 delayed male fertility "ability of a male organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009200 enlarged external male genitalia "increased size of the external masculine genital organs, including the penis and scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0009421 increased gastrocnemius weight "increase in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fsttm1Zuk/Fst+,Mstntm1Sjl/Mstn+
Genetic Background: B6.129-Mstntm1Sjl Fsttm1Zuk

 MP:0009433 polyovular ovarian follicle "an ovarian follicle containing more than one oocyte (ovum)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Inhbatm1Zuk/Inhbatm3Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Mycntm1Knd/Mycntm1Knd
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0009894 absent hard palate "absence of the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones in the adult" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mycntm1Knd/Mycntm1Knd
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbatm2Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inhbatm1Zuk/Inhbatm2Zuk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010226 increased quadriceps weight "increase in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fsttm1Zuk/Fst+,Mstntm1Sjl/Mstn+
Genetic Background: B6.129-Mstntm1Sjl Fsttm1Zuk

 MP:0010234 abnormal vibrissa follicle morphology "any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mycntm1Knd/Mycntm1Knd
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010238 increased skeletal muscle weight "greater than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fsttm1Zuk/Fst+,Mstntm1Sjl/Mstn+
Genetic Background: B6.129-Mstntm1Sjl Fsttm1Zuk

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mycntm1Knd/Mycntm1Knd
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Inhbatm1Zuk/Inhbatm1Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025405 Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*  / complex
 ENSMUSG00000026834 Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*  / reaction / complex
 ENSMUSG00000037035 Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*  / complex
 ENSMUSG00000000532 Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*  / reaction / complex
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / reaction / complex
 ENSMUSG00000041324 Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*  / complex
 ENSMUSG00000032968 Inha / Q04997 / Inhibin alpha chain / P05111* / inhibin alpha subunit*  / complex
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / reaction / complex
 ENSMUSG00000021765 Fst / follistatin FST315 / P19883* / follistatin*  / reaction / complex
 ENSMUSG00000020325 Fstl3 / Q9EQC7 / Follistatin-related protein 3 / O95633* / follistatin like 3*  / complex / reaction
 ENSMUSG00000047492 Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*  / complex






 

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