ENSGALG00000034616


Gallus gallus

Features
Gene ID: ENSGALG00000034616
  
Biological name :INHBA
  
Synonyms : INHBA / inhibin beta A chain precursor
  
Possible biological names infered from orthology : Inhibin beta A chain / inhibin beta A subunit / P08476 / Q04998
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 50747740
Gene end: 50762675
  
Corresponding Affymetrix probe sets: Gga.3982.1.S1_at (Chicken Array)   Gga.3982.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000063488
Ensembl peptide - ENSGALP00000044244
NCBI entrez gene - 396361     See in Manteia.
RefSeq - XM_015281320
RefSeq - NM_205396
RefSeq Peptide - NP_990727
swissprot - A0A1D5NV71
Ensembl - ENSGALG00000034616
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inhbaaENSDARG00000012671Danio rerio
 inhbabENSDARG00000024759Danio rerio
 INHBAENSG00000122641Homo sapiens
 InhbaENSMUSG00000041324Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INHBB / inhibin beta B chain precursor / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSGALG0000002877039
TGFB3 / transforming growth factor beta 3 / P10600*ENSGALG0000001034620
TGFB2 / P27090* / P61812* / transforming growth factor beta 2* / Transforming growth factor beta-2 Latency-associated peptide*ENSGALG0000000961219
GDF8 / O42220 / Growth/differentiation factor 8 / MSTN* / O08689* / O14793* / myostatin*ENSGALG0000003945819
GDF3 / embryonic growth/differentiation factor 1 / GDF1* / CERS1* / P27545* / P27544* / Q9NR23* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 3* / gr...ENSGALG0000000316118
BMP15 / bone morphogenetic protein 15 precursor ENSGALG0000000474215
BMP3 / bone morphogenetic protein 3 precursor / P12645* / Q8BHE5* / Bone morphotic protein 3 * / bone morphogenetic protein 3*ENSGALG0000003505214
GDF9 / growth differentiation factor 9 / O60383* / Q07105*ENSGALG0000002840714
GDF10 / growth differentiation factor 10 / P55107* / P97737*ENSGALG0000000598514
NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*ENSGALG0000000320913
GDF15* / Q99988* / Q9Z0J7* / growth differentiation factor 15* / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA.*ENSGALG000000462787


Protein motifs (from Interpro)
Interpro ID Name
 IPR000491  Inhibin, beta A subunit
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0021773 striatal medium spiny neuron differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0032924 activin receptor signaling pathway IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042541 hemoglobin biosynthetic process IEA
 biological_processGO:0042701 progesterone secretion IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046880 regulation of follicle-stimulating hormone secretion IEA
 biological_processGO:0048333 mesodermal cell differentiation IEA
 biological_processGO:0051799 negative regulation of hair follicle development IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060279 positive regulation of ovulation IEA
 biological_processGO:0061029 eyelid development in camera-type eye IEA
 biological_processGO:0097154 GABAergic neuron differentiation IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0043509 activin A complex IEA
 cellular_componentGO:0043512 inhibin A complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0070699 type II activin receptor binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000028770 INHBB / inhibin beta B chain precursor / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*  / complex
 ENSGALG00000029599 ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *  / complex / reaction
 ENSGALG00000029515 P43031 / Inhibin alpha chain / INHA* / Q04997* / P05111* / inhibin alpha subunit*  / complex
 ENSGALG00000012444 ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*  / reaction / complex
 ENSGALG00000034616 INHBA / inhibin beta A chain precursor / P08476* / Q04998* / Inhibin beta A chain * / inhibin beta A subunit*  / complex
 ENSGALG00000041257 ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *  / complex
 ENSGALG00000006158 ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*  / complex / reaction
 ENSGALG00000042356 FSTL3 / follistatin like 3 / O95633* / Q9EQC7* / Follistatin-related protein 3 *  / complex / reaction






 

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