ENSGALG00000009612


Gallus gallus

Features
Gene ID: ENSGALG00000009612
  
Biological name :TGFB2
  
Synonyms : TGFB2
  
Possible biological names infered from orthology : P27090 / P61812 / transforming growth factor beta 2 / Transforming growth factor beta-2 Latency-associated peptide
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 19369482
Gene end: 19432348
  
Corresponding Affymetrix probe sets: Gga.8797.1.S1_at (Chicken Array)   GgaAffx.22982.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000031309
NCBI entrez gene - 421352     See in Manteia.
RefSeq - NM_001031045
RefSeq Peptide - NP_001026216
swissprot - F1NNP2
Ensembl - ENSGALG00000009612
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgfb2ENSDARG00000027087Danio rerio
 TGFB2ENSG00000092969Homo sapiens
 Tgfb2ENSMUSG00000039239Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TGFB3 / transforming growth factor beta 3 / P10600*ENSGALG0000001034656
GDF8 / O42220 / Growth/differentiation factor 8 / MSTN* / O08689* / O14793* / myostatin*ENSGALG0000003945824
INHBA / inhibin beta A chain precursor / P08476* / Q04998* / Inhibin beta A chain * / inhibin beta A subunit*ENSGALG0000003461620
INHBB / inhibin beta B chain precursor / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSGALG0000002877018
GDF3 / embryonic growth/differentiation factor 1 / GDF1* / CERS1* / P27545* / P27544* / Q9NR23* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 3* / gr...ENSGALG0000000316115
BMP15 / bone morphogenetic protein 15 precursor ENSGALG0000000474214
GDF10 / growth differentiation factor 10 / P55107* / P97737*ENSGALG0000000598514
GDF9 / growth differentiation factor 9 / O60383* / Q07105*ENSGALG0000002840713
BMP3 / bone morphogenetic protein 3 precursor / P12645* / Q8BHE5* / Bone morphotic protein 3 * / bone morphogenetic protein 3*ENSGALG0000003505213
NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*ENSGALG0000000320912
GDF15* / Q99988* / Q9Z0J7* / growth differentiation factor 15* / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA.*ENSGALG000000462786


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR003940  Transforming growth factor, beta 2
 IPR015615  Transforming growth factor-beta-related
 IPR016319  Transforming growth factor-beta
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis ISS
 biological_processGO:0001654 eye development ISS
 biological_processGO:0001837 epithelial to mesenchymal transition ISS
 biological_processGO:0003007 heart morphogenesis ISS
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0007050 cell cycle arrest ISS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISS
 biological_processGO:0007435 salivary gland morphogenesis ISS
 biological_processGO:0007507 heart development ISS
 biological_processGO:0008219 cell death ISS
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0008347 glial cell migration ISS
 biological_processGO:0009611 response to wounding ISS
 biological_processGO:0010002 cardioblast differentiation ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration ISS
 biological_processGO:0010693 negative regulation of alkaline phosphatase activity ISS
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISS
 biological_processGO:0010936 negative regulation of macrophage cytokine production ISS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0023014 signal transduction by protein phosphorylation ISS
 biological_processGO:0030199 collagen fibril organization ISS
 biological_processGO:0030307 positive regulation of cell growth ISS
 biological_processGO:0030308 negative regulation of cell growth ISS
 biological_processGO:0032147 activation of protein kinase activity ISS
 biological_processGO:0032570 response to progesterone ISS
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade ISS
 biological_processGO:0032909 regulation of transforming growth factor beta2 production ISS
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin ISS
 biological_processGO:0042493 response to drug ISS
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISS
 biological_processGO:0045216 cell-cell junction organization ISS
 biological_processGO:0045726 positive regulation of integrin biosynthetic process ISS
 biological_processGO:0045778 positive regulation of ossification ISS
 biological_processGO:0045823 positive regulation of heart contraction ISS
 biological_processGO:0048566 embryonic digestive tract development ISS
 biological_processGO:0050680 negative regulation of epithelial cell proliferation ISS
 biological_processGO:0050714 positive regulation of protein secretion ISS
 biological_processGO:0051795 positive regulation of timing of catagen ISS
 biological_processGO:0051891 positive regulation of cardioblast differentiation ISS
 biological_processGO:0060038 cardiac muscle cell proliferation ISS
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition ISS
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation ISS
 biological_processGO:0060395 SMAD protein signal transduction ISS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix ISS
 molecular_functionGO:0001540 amyloid-beta binding ISS
 molecular_functionGO:0005102 signaling receptor binding ISS
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding ISS
 molecular_functionGO:0005160 transforming growth factor beta receptor binding ISS
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0034714 type III transforming growth factor beta receptor binding ISS
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
Platelet degranulation
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010448 LTBP1 / latent-transforming growth factor beta-binding protein 1 precursor / Q14766* / Q8CG19* / latent transforming growth factor beta binding protein 1*  / complex / reaction
 ENSGALG00000009612 TGFB2 / P27090* / P61812* / transforming growth factor beta 2* / Transforming growth factor beta-2 Latency-associated peptide*  / complex






 

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