Manteia

ENSDARG00000027087

Danio rerio

Features

Gene ID:	ENSDARG00000027087

Biological name :	tgfb2

Synonyms :	tgfb2 / transforming growth factor, beta 2

Possible biological names infered from orthology :	P27090 / P61812 / Transforming growth factor beta-2 Latency-associated peptide

Species:	Danio rerio

Chr. number:	16
Strand:	-1
Band:
Gene start:	2745006
Gene end:	2807527

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000123937 NCBI entrez gene - 369194 See in Manteia. RefSeq - NM_194385 RefSeq Peptide - NP_919366 swissprot - F8W4A6 ZFIN ID - ZDB-GENE-030723-3 Ensembl - ENSDARG00000027087

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
TGFB2	ENSGALG00000009612	Gallus gallus
TGFB2	ENSG00000092969	Homo sapiens
Tgfb2	ENSMUSG00000039239	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
tgfb2l / transforming growth factor, beta 2, like	ENSDARG00000071879	57
tgfb3 / transforming growth factor, beta 3 / P10600*	ENSDARG00000019367	55
tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*	ENSDARG00000034895	38
tgfb1a / transforming growth factor, beta 1a / TGFB1* / P01137* / transforming growth factor beta 1*	ENSDARG00000041502	37
mstnb / O42222 / myostatin b / MSTN* / O08689* / O14793* / myostatin*	ENSDARG00000069133	23
mstna / myostatin a / MSTN* / O14793* / O08689* / myostatin*	ENSDARG00000042947	21
gdf11 / growth differentiation factor 11 / O95390* / Q9Z1W4*	ENSDARG00000044924	21
inhbab / inhibin, beta Ab / INHBA* / P08476* / inhibin beta A subunit*	ENSDARG00000024759	20
INHBE / inhibin beta E subunit / INHBC* / P58166* / P55103* / inhibin beta C subunit*	ENSDARG00000100986	19
inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*	ENSDARG00000040777	18
inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*	ENSDARG00000012671	18
gdf3 / P35621 / growth differentiation factor 3 / GDF1* / CERS1* / Q9NR23* / P27544* / P27545* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 1* / Embr...	ENSDARG00000037995	17
ndr2 / nodal-related 2 / NODAL* / Q96S42* / nodal growth differentiation factor*	ENSDARG00000101279	16
gdf10a / growth differentiation factor 10a / GDF10* / P97737* / P55107* / growth differentiation factor 10*	ENSDARG00000095378	15
gdf9 / growth differentiation factor 9 / O60383* / Q07105*	ENSDARG00000003229	15
bmp15 / bone morphogenetic protein 15	ENSDARG00000037491	14
ndr1 / nodal-related 1 / NODAL* / Q96S42* / P43021* / nodal growth differentiation factor*	ENSDARG00000057096	14
bmp3 / bone morphogenetic protein 3 / P12645* / Q8BHE5* / Bone morphotic protein 3 *	ENSDARG00000060526	14
CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*	ENSDARG00000103892	14
spaw / southpaw / NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*	ENSDARG00000014309	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR001111	TGF-beta, propeptide
IPR001839	Transforming growth factor-beta, C-terminal
IPR003940	Transforming growth factor, beta 2
IPR015615	Transforming growth factor-beta-related
IPR016319	Transforming growth factor-beta
IPR017948	Transforming growth factor beta, conserved site
IPR029034	Cystine-knot cytokine

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA
biological_process	GO:0030509	BMP signaling pathway	IBA
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0042981	regulation of apoptotic process	IBA
biological_process	GO:0043408	regulation of MAPK cascade	IBA
biological_process	GO:0048468	cell development	IBA
biological_process	GO:0060022	hard palate development	IMP
biological_process	GO:0060395	SMAD protein signal transduction	IBA
biological_process	GO:0061056	sclerotome development	IMP
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
molecular_function	GO:0005114	type II transforming growth factor beta receptor binding	IBA
molecular_function	GO:0005125	cytokine activity	IBA
molecular_function	GO:0005160	transforming growth factor beta receptor binding	IEA
molecular_function	GO:0008083	growth factor activity	IEA

Pathways (from Reactome)

Pathway description

Platelet degranulation

Molecules associated with elastic fibres

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000561	parasphenoid	parasphenoid shape , abnormal parasphenoid decreased length , abnormal	Show
ZFA:0001205	Meckel s cartilage	Meckels cartilage decreased size , abnormal	Show
ZFA:0001227	mandibular arch skeleton	mandibular arch skeleton shape , abnormal mandibular arch skeleton decreased length , abnormal	Show
ZFA:0001405	ethmoid cartilage	ethmoid cartilage shape , abnormal ethmoid cartilage decreased length , abnormal	Show
ZFA:0001507	trabecula cranii	trabecula cranii shape , abnormal trabecula cranii decreased length , abnormal	Show
ZFA:0005509	palate	palate shape , abnormal palate decreased size , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr