ENSDARG00000101279


Danio rerio

Features
Gene ID: ENSDARG00000101279
  
Biological name :ndr2
  
Synonyms : ndr2 / nodal-related 2
  
Possible biological names infered from orthology : NODAL / nodal growth differentiation factor / P43021 / Q96S42
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 48204891
Gene end: 48220619
  
Corresponding Affymetrix probe sets: Dr.18289.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000141440
Ensembl peptide - ENSDARP00000157283
swissprot - A0A0R4IZE5
ZFIN ID - ZDB-GENE-990415-181
Ensembl - ENSDARG00000101279
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NODALENSG00000156574Homo sapiens
 NodalENSMUSG00000037171Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ndr1 / nodal-related 1 / NODAL* / Q96S42* / P43021* / nodal growth differentiation factor*ENSDARG0000005709624
spaw / southpaw / NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*ENSDARG0000001430923
gdf3 / P35621 / growth differentiation factor 3 / GDF1* / CERS1* / Q9NR23* / P27544* / P27545* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 1* / Embr...ENSDARG0000003799515
tgfb2 / transforming growth factor, beta 2 / P27090* / P61812* / Transforming growth factor beta-2 Latency-associated peptide*ENSDARG0000002708713
tgfb3 / transforming growth factor, beta 3 / P10600*ENSDARG0000001936713
bmp3 / bone morphogenetic protein 3 / P12645* / Q8BHE5* / Bone morphotic protein 3 *ENSDARG0000006052613
gdf10b / growth differentiation factor 10b / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000007389113
gdf10a / growth differentiation factor 10a / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000009537813
tgfb2l / transforming growth factor, beta 2, likeENSDARG0000007187912
tgfb1a / transforming growth factor, beta 1a / TGFB1* / P01137* / transforming growth factor beta 1*ENSDARG0000004150212
bmp15 / bone morphogenetic protein 15ENSDARG0000003749112
inhbab / inhibin, beta Ab / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000002475912
mstna / myostatin a / MSTN* / O14793* / O08689* / myostatin*ENSDARG0000004294711
inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSDARG0000004077711
inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000001267111
mstnb / O42222 / myostatin b / MSTN* / O08689* / O14793* / myostatin*ENSDARG0000006913311
tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*ENSDARG0000003489511
gdf9 / growth differentiation factor 9 / O60383* / Q07105*ENSDARG0000000322911
INHBE / inhibin beta E subunit / INHBC* / P58166* / P55103* / inhibin beta C subunit*ENSDARG0000010098611
gdf11 / growth differentiation factor 11 / O95390* / Q9Z1W4*ENSDARG0000004492411


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001709 cell fate determination IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014028 notochord formation IDA
 biological_processGO:0021508 floor plate formation IMP
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021854 hypothalamus development IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0033504 floor plate development IMP
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0046619 optic placode formation involved in camera-type eye formation IMP
 biological_processGO:0048048 embryonic eye morphogenesis IMP
 biological_processGO:0048382 mesendoderm development IMP
 biological_processGO:0048839 inner ear development IGI
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060061 Spemann organizer formation IMP
 biological_processGO:2000223 regulation of BMP signaling pathway involved in heart jogging IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain medial region decreased size , abnormal
brain morphology , abnormal
Show

 ZFA:0000012 central nervous system central nervous system ventral region decreased size , abnormal
Show

 ZFA:0000022 floor plate floor plate quality , abnormal
floor plate aplastic , abnormal
floor plate decreased size , abnormal
floor plate ventral region hypoplastic , abnormal
floor plate absent , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus decreased size , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate hypoplastic , abnormal
Show

 ZFA:0000075 spinal cord spinal cord morphology , abnormal
Show

 ZFA:0000101 diencephalon diencephalon decreased size , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
eye fused with eye , abnormal
eye anterior region decreased distance eye anterior region, abnormal
eye decreased distance eye , abnormal
Show

 ZFA:0000109 forebrain forebrain quality , abnormal
forebrain decreased size , abnormal
forebrain ventral region constricted , abnormal
forebrain increased size , abnormal
Show

 ZFA:0000112 gut gut hypoplastic , abnormal
gut quality , abnormal
Show

 ZFA:0000123 liver liver hypoplastic , abnormal
liver quality , abnormal
Show

 ZFA:0000135 notochord notochord poorly differentiated , abnormal
Show

 ZFA:0000217 inner ear inner ear wholly anterioralized , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000558 posterior macula posterior macula aplastic , abnormal
Show

 ZFA:0001086 muscle pioneer muscle pioneer absent , abnormal
Show

 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism lacks all parts of type brain ventral region, abnormal
whole organism bent , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region curved ventral , abnormal
Show

 ZFA:0001120 neuroectoderm neuroectoderm morphology , abnormal
Show

 ZFA:0001617 otolith otolith decreased size , abnormal
Show

 ZFA:0001678 immature eye immature eye malformed , abnormal
immature eye decreased amount , abnormal
Show

 ZFA:0005409 pars superior ear pars superior ear has extra parts of type anterior crista , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell decreased amount , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon ipsilateral to eye , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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